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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/04 12:33:57」(JST)
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Retinoblastoma-like 2 |
Identifiers |
Symbols |
RBL2 ; P130; Rb2 |
External IDs |
OMIM: 180203 MGI: 105085 HomoloGene: 4098 GeneCards: RBL2 Gene |
Gene ontology |
Molecular function |
• DNA binding
• protein binding
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Cellular component |
• nucleus
• nucleoplasm
• transcription factor complex
• nucleolus
• cytoplasm
• extracellular vesicular exosome
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Biological process |
• mitotic cell cycle
• transcription, DNA-templated
• regulation of transcription from RNA polymerase II promoter
• chromatin modification
• regulation of lipid kinase activity
• regulation of cell cycle
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
5934 |
19651 |
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Ensembl |
ENSG00000103479 |
ENSMUSG00000031666 |
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UniProt |
Q08999 |
Q64700 |
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RefSeq (mRNA) |
NM_005611 |
NM_001282000 |
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RefSeq (protein) |
NP_005602 |
NP_001268929 |
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Location (UCSC) |
Chr 16:
53.47 – 53.53 Mb |
Chr 8:
91.07 – 91.12 Mb |
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PubMed search |
[1] |
[2] |
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Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.[1][2]
Contents
- 1 Interactions
- 2 See also
- 3 Further reading
- 4 References
- 5 External links
Interactions
Retinoblastoma-like protein 2 has been shown to interact with HDAC1,[3][4] C-Raf,[5] RBBP8,[6][7] Cyclin E1,[8][9] Prohibitin,[10] Cyclin-dependent kinase 2,[8][11] BRF1[12] and BRCA1.[13]
See also
Further reading
- Soprano KJ, Purev E, Vuocolo S, Soprano DR (2006). "Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid.". Oncogene 25 (38): 5315–25. doi:10.1038/sj.onc.1209679. PMID 16936753.
- De Falco G, Giordano A (2006). "pRb2/p130: a new candidate for retinoblastoma tumor formation.". Oncogene 25 (38): 5333–40. doi:10.1038/sj.onc.1209614. PMID 16936755.
- Hijmans EM, Voorhoeve PM, Beijersbergen RL, et al. (1995). "E2F-5, a new E2F family member that interacts with p130 in vivo.". Mol. Cell. Biol. 15 (6): 3082–9. PMC 230539. PMID 7760804.
- Sardet C, Vidal M, Cobrinik D, et al. (1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279.
- Yeung RS, Bell DW, Testa JR, et al. (1993). "The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19.". Oncogene 8 (12): 3465–8. PMID 8247552.
- Li Y, Graham C, Lacy S, et al. (1994). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.". Genes Dev. 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.
- Hannon GJ, Demetrick D, Beach D (1994). "Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.". Genes Dev. 7 (12A): 2378–91. doi:10.1101/gad.7.12a.2378. PMID 8253384.
- Lavender P, Vandel L, Bannister AJ, Kouzarides T (1997). "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A.". Oncogene 14 (22): 2721–8. doi:10.1038/sj.onc.1201243. PMID 9178770.
- Lacy S, Whyte P (1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes.". Oncogene 14 (20): 2395–406. doi:10.1038/sj.onc.1201085. PMID 9188854.
- Shao Z, Siegert JL, Ruppert S, Robbins PD (1997). "Rb interacts with TAF(II)250/TFIID through multiple domains.". Oncogene 15 (4): 385–92. doi:10.1038/sj.onc.1201204. PMID 9242374.
- Sterner JM, Dew-Knight S, Musahl C, et al. (1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.". Mol. Cell. Biol. 18 (5): 2748–57. PMC 110654. PMID 9566894.
- Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.". Nat. Genet. 19 (4): 371–4. doi:10.1038/1258. PMID 9697699.
- Veal E, Eisenstein M, Tseng ZH, Gill G (1998). "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F.". Mol. Cell. Biol. 18 (9): 5032–41. PMC 109088. PMID 9710587.
- Fusco C, Reymond A, Zervos AS (1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein.". Genomics 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.
- Ferreira R, Magnaghi-Jaulin L, Robin P, et al. (1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10493–8. doi:10.1073/pnas.95.18.10493. PMC 27922. PMID 9724731.
- Paramio JM, Laín S, Segrelles C, et al. (1998). "Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation.". Oncogene 17 (8): 949–57. doi:10.1038/sj.onc.1202031. PMID 9747874.
- Wang S, Ghosh RN, Chellappan SP (1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation.". Mol. Cell. Biol. 18 (12): 7487–98. PMC 109329. PMID 9819434.
- Yang R, Müller C, Huynh V, et al. (1999). "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins.". Mol. Cell. Biol. 19 (3): 2400–7. PMC 84032. PMID 10022926.
References
- ^ Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (September 1993). "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain". Oncogene 8 (9): 2561–6. PMID 8361765.
- ^ Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (July 1996). "Genomic structure of the human retinoblastoma-related Rb2/p130 gene". Proc Natl Acad Sci U S A 93 (10): 4629–32. doi:10.1073/pnas.93.10.4629. PMC 39329. PMID 8643454.
- ^ Ferreira, R; Magnaghi-Jaulin L; Robin P; Harel-Bellan A; Trouche D (September 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (18): 10493–8. doi:10.1073/pnas.95.18.10493. ISSN 0027-8424. PMC 27922. PMID 9724731.
- ^ Bouzahzah, B; Fu M; Iavarone A; Factor V M; Thorgeirsson S S; Pestell R G (August 2000). "Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo". Cancer Res. (UNITED STATES) 60 (16): 4531–7. ISSN 0008-5472. PMID 10969803.
- ^ Wang, S; Ghosh R N; Chellappan S P (Dec 1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation". Mol. Cell. Biol. (UNITED STATES) 18 (12): 7487–98. ISSN 0270-7306. PMC 109329. PMID 9819434.
- ^ Meloni, A R; Smith E J; Nevins J R (August 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574–9. doi:10.1073/pnas.96.17.9574. ISSN 0027-8424. PMC 22250. PMID 10449734.
- ^ Fusco, C; Reymond A; Zervos A S (August 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics (UNITED STATES) 51 (3): 351–8. doi:10.1006/geno.1998.5368. ISSN 0888-7543. PMID 9721205.
- ^ a b Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460–9. ISSN 0270-7306. PMC 116074. PMID 9891079.
- ^ Li, Y; Graham C; Lacy S; Duncan A M; Whyte P (Dec 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. (UNITED STATES) 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. ISSN 0890-9369. PMID 8253383.
- ^ Wang, S; Nath N; Adlam M; Chellappan S (June 1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene (ENGLAND) 18 (23): 3501–10. doi:10.1038/sj.onc.1202684. ISSN 0950-9232. PMID 10376528.
- ^ Lacy, S; Whyte P (May 1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes". Oncogene (ENGLAND) 14 (20): 2395–406. doi:10.1038/sj.onc.1201085. ISSN 0950-9232. PMID 9188854.
- ^ Sutcliffe, J E; Cairns C A; McLees A; Allison S J; Tosh K; White R J (June 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255–61. ISSN 0270-7306. PMC 104385. PMID 10330166.
- ^ Fan, S; Yuan R; Ma Y X; Xiong J; Meng Q; Erdos M; Zhao J N; Goldberg I D; Pestell R G; Rosen E M (August 2001). "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene (England) 20 (35): 4827–41. doi:10.1038/sj.onc.1204666. ISSN 0950-9232. PMID 11521194.
External links
- RBL2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Transcription factors and intracellular receptors
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(1) Basic domains
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(1.1) Basic leucine zipper (bZIP) |
- Activating transcription factor
- AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
- BACH
- BATF
- BLZF1
- C/EBP
- CREB
- CREM
- DBP
- DDIT3
- GABPA
- HLF
- MAF
- NFE
- NFIL3
- NRL
- NRF
- XBP1
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(1.2) Basic helix-loop-helix (bHLH) |
- ATOH1
- AhR
- AHRR
- ARNT
- ASCL1
- BHLH
- ARNTL
- CLOCK
- EPAS1
- FIGLA
- HAND
- HES
- HEY
- HES1
- HIF
- ID
- LYL1
- MESP2
- MXD4
- MYCL1
- MYCN
- Myogenic regulatory factors
- Neurogenins
- NeuroD
- NPAS
- OLIG
- Pho4
- Scleraxis
- SIM
- TAL
- Twist
- USF1
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(1.3) bHLH-ZIP |
- AP-4
- MAX
- MITF
- MNT
- MLX
- MXI1
- Myc
- SREBP
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(1.4) NF-1 |
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(1.5) RF-X |
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(1.6) Basic helix-span-helix (bHSH) |
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(2) Zinc finger DNA-binding domains
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(2.1) Nuclear receptor (Cys4) |
subfamily 1 |
- Thyroid hormone
- CAR
- FXR
- LXR
- PPAR
- PXR
- RAR
- ROR
- Rev-ErbA
- VDR
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subfamily 2 |
- COUP-TF
- Ear-2
- HNF4
- PNR
- RXR
- Testicular receptor
- TLX
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subfamily 3 |
- Steroid hormone
- Androgen
- Estrogen
- Glucocorticoid
- Mineralocorticoid
- Progesterone
- Estrogen related
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subfamily 4 |
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subfamily 5 |
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subfamily 6 |
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subfamily 0 |
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(2.2) Other Cys4 |
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(2.3) Cys2His2 |
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(2.4) Cys6 |
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(2.5) Alternating composition |
- AIRE
- DIDO1
- GRLF1
- ING
- JARID
- JMJD1B
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(2.6) WRKY |
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(3) Helix-turn-helix domains
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(4) β-Scaffold factors with minor groove contacts
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(4.1) Rel homology region |
- NF-κB
- NFKB1
- NFKB2
- REL
- RELA
- RELB
- NFAT
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(4.2) STAT |
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(4.3) p53 |
- p53
- TBX
- 1
- 2
- 3
- 5
- 19
- 21
- 22
- TBR1
- TBR2
- TFT
- MYRF
- TP63
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(4.4) MADS box |
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(4.6) TATA-binding proteins |
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(4.7) High-mobility group |
- BBX
- HMGB
- HMGN
- HNF
- LEF1
- SOX
- 1
- 2
- 3
- 4
- 5
- 6
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 18
- 21
- SRY
- SSRP1
- TCF
- TOX
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(4.9) Grainyhead |
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(4.10) Cold-shock domain |
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(4.11) Runt |
- CBF
- CBFA2T2
- CBFA2T3
- RUNX1
- RUNX2
- RUNX3
- RUNX1T1
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(0) Other transcription factors
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(0.2) HMGI(Y) |
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(0.3) Pocket domain |
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(0.5) AP-2/EREBP-related factors |
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(0.6) Miscellaneous |
- ARID
- CAP
- IFI
- MLL
- MNDA
- NFY
- Rho/Sigma
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see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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English Journal
- Prenatal Diagnosis of DNA Copy Number Variations by Genomic Single-Nucleotide Polymorphism Array in Fetuses with Congenital Heart Defects.
- Tang S1, Lv J, Chen X, Bai L, Li H, Chen C, Wang P, Xu X, Lu J.
- Fetal diagnosis and therapy.Fetal Diagn Ther.2015 Jul 10. [Epub ahead of print]
- OBJECTIVES: To evaluate the usefulness of single-nucleotide polymorphism (SNP) array for prenatal genetic diagnosis of congenital heart defect (CHD), we used this approach to detect clinically significant copy number variants (CNVs) in fetuses with CHDs.METHODS: A HumanCytoSNP-12 array was used to d
- PMID 26184588
- Onset of hepatocarcinogen-specific cell proliferation and cell cycle aberration during the early stage of repeated hepatocarcinogen administration in rats.
- Kimura M1,2, Abe H1,2, Mizukami S1,2, Tanaka T1,2, Itahashi M1,2, Onda N1, Yoshida T1, Shibutani M1.
- Journal of applied toxicology : JAT.J Appl Toxicol.2015 May 22. doi: 10.1002/jat.3163. [Epub ahead of print]
- We have previously reported that a 28-day treatment of carcinogens evoking target cell proliferation activates G1 /S checkpoint function and apoptosis, as well as induction of aberrant ubiquitin D (Ubd) expression, suggesting disruptive spindle checkpoint function, in rats. The present study aimed t
- PMID 26011634
- pRb2/p130 localizes to the cytoplasm in diffuse gastric cancer.
- Cito L1, Indovina P, Forte IM, Pentimalli F, Di Marzo D, Somma P, Barone D, Penon A, Penon D, Ceccherini E, Micheli P, Saragoni L, Di Domenico M, Feola A, Roviello F, Mattioli E, Giordano GG, Giordano A.
- Journal of cellular physiology.J Cell Physiol.2015 Apr;230(4):802-5. doi: 10.1002/jcp.24805.
- pRb2/p130 is a key tumor suppressor, whose oncosuppressive activity has mainly been attributed to its ability to negatively regulate cell cycle by interacting with the E2F4 and E2F5 transcription factors. Indeed, pRb2/p130 has been found altered in various cancer types in which it functions as a val
- PMID 25205458
Japanese Journal
- Disruption of spindle checkpoint function ahead of facilitation of cell proliferation by repeated administration of hepatocarcinogens in rats
- 核内受容体PXRによるマウス肝細胞の細胞周期調節機序
- Sake Less Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation
- Bioscience, biotechnology, and biochemistry 75(1), 140-144, 2011-01-23
- NAID 10027897025
Related Links
- RBL2 retinoblastoma-like 2 (p130) [Homo sapiens (human)]. Gene ID: 5934, updated on 20-Apr-2013. Summary. Other designations. 130 kDa retinoblastoma -associated protein, PRB2, RBR-2, retinoblastoma-like protein 2, ...
- Complete information for RBL2 gene (protein-coding), retinoblastoma-like 2 ( p130)
Related Pictures