English Journal

Screening of marine extracts for schistosomicidal activity in vitro. Isolation of the triterpene glycosides echinosides A and B with potential activity from the Sea Cucumbers Actinopyga echinites and Holothuria polii.

Melek FR, Tadros MM, Yousif F, Selim MA, Hassan MH.SourceNatural Compounds Department. National Research Center , Giza , Egypt.
Pharmaceutical biology.Pharm Biol.2012 Apr;50(4):490-6. Epub 2011 Dec 2.
Context: Praziquantel (PZQ) is the drug available for the treatment of schistosomiasis. The reported reduced cure rates, the failure of treatment after PZQ administration in patients and the existence of resistant parasite strains, reinforce the need to rapidly discover new effective molecules again
PMID 22136393

Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development.

Caracciolo V, Laurenti G, Romano G, Carnevale V, Cimini AM, Crozier-Fitzgerald C, Gentile E, Russo G, Giordano A.SourceThese authors contributed equally to this work.; Sbarro Institute for Cancer Research and Molecular Medicine; Center for Biotechnology; College of Science and Technology; Temple University; Philadelphia, PA USA.
Cell cycle (Georgetown, Tex.).Cell Cycle.2012 Mar 15;11(6). [Epub ahead of print]
Cdk9 and Cdk7 are cdc2-like serine/threonine kinases that stabilize RNA transcript elongation through RNA polII carboxyl terminal domain (CTD) phosphorylation and are considered suitable targets for cancer therapy. The effects of flavopiridol and of siRNA-mediated inhibition of Cdk9 and/or Cdk7 we
PMID 22391209

Japanese Journal

Effects of War on Biodiversity and Sustainable Agricultural Development in Afghanistan

Saidajan Abdiani
Journal of Developments in Sustainable Agriculture 7(1), 9-13, 2012
… Afghanistan is rich in biodiversity and natural beauty, and is home to globally significant wildlife species such as Marco Polo sheep (<I>Ovis ammon polii</I>) and the snow leopard (<I>Uncia uncia</I>), which are under pressure from hunting, loss of habitat, and illegal trade. …
NAID 130004946416