- 日
- 関
- 関
- See Phenylethanolamine-N-methyltrans fe ras e
- 関
- Phenylethanolamine-N- methyltran sferase
- 関
- See Phenylethanolamine-N-methyltrans fe ras e
- 関
- Phenylethanolamine-N- methyltran sferase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/18 14:35:46」(JST)
[Wiki en表示]
phenylethanolamine N-methyltransferase |
Identifiers |
Symbol |
PNMT |
Alt. symbols |
PENT |
Entrez |
5409 |
HUGO |
9160 |
OMIM |
171190 |
RefSeq |
NM_002686 |
UniProt |
P11086 |
Other data |
Locus |
Chr. 17 q21-q22 |
Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts norepinephrine (noradrenaline) to epinephrine (adrenaline).
PNMT is positively influenced by cortisol, which is produced in the adrenal cortex.
S-adenosyl-L-methionine (SAM) is a required cofactor.[1] PNMT catalyzes the transfer of a methyl group from SAM to norepinephrine, converting it into epinephrine. This enzyme also converts phenethylamine to N-methylphenethylamine, an isomer of amphetamine.[2][3]
L-Phenylalanine
L-Tyrosine
L-Dopa
Epinephrine
Phenethylamine
p-Tyramine
Dopamine
Norepinephrine
N-Methylphenethylamine
N-Methyltyramine
p-Octopamine
Synephrine
3-Methoxytyramine
AADC
AADC
AADC
PNMT
PNMT
PNMT
PNMT
AAAH
AAAH
COMT
DBH
DBH
PNMT plays an important role in trace amine and catecholamine biosynthesis.
References[edit]
- ^ Wong DL, Lesage A, Siddall B, Funder JW (November 1992). "Glucocorticoid regulation of phenylethanolamine N-methyltransferase in vivo". The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 6 (14): 3310–5. PMID 1426768.
- ^ Pendleton, RG; Gessner, G; Sawyer, J (September 1980). "Studies on lung N-methyltransferases, a pharmacological approach.". Naunyn-Schmiedeberg's archives of pharmacology 313 (3): 263–8. doi:10.1007/BF00505743. PMID 7432557.
- ^ Broadley, KJ (March 2010). "The vascular effects of trace amines and amphetamines.". Pharmacology & therapeutics 125 (3): 363–75. doi:10.1016/j.pharmthera.2009.11.005. PMID 19948186.
External links[edit]
- Phenylethanolamine N-Methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
Transferase: one carbon transferases (EC 2.1)
|
|
2.1.1: Methyl- |
N- |
- Histamine N-methyltransferase
- Phenylethanolamine N-methyltransferase
- Amine N-methyltransferase
- Phosphatidylethanolamine N-methyltransferase
|
|
O- |
- 5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase
- Catechol-O-methyl transferase
|
|
Homocysteine |
- Betaine-homocysteine methyltransferase
- Homocysteine methyltransferase
- Methionine synthase
|
|
Other |
- Phosphatidyl ethanolamine methyltransferase
- DNMT3B
- Histone methyltransferase
- Thymidylate synthase
- DNA methyltransferase
- Thiopurine methyltransferase
|
|
|
2.1.2: Hydroxymethyl-,
Formyl- and Related |
Hydroxymethyltransferase |
- Serine hydroxymethyltransferase
- 3-methyl-2-oxobutanoate hydroxymethyltransferase
|
|
Formyltransferase |
- Phosphoribosylglycinamide formyltransferase
- Inosine monophosphate synthase
|
|
Other |
- Glutamate formimidoyltransferase
- Aminomethyltransferase
|
|
|
2.1.3: Carboxy- and Carbamoyl |
Carboxy |
- methylmalonyl-CoA carboxytransferase
|
|
Carbamoyl |
- Aspartate carbamoyltransferase
- Ornithine carbamoyltransferase
- Oxamate carbamoyltransferase
- Putrescine carbamoyltransferase
- 3-hydroxymethylcephem carbamoyltransferase
- Lysine carbamoyltransferase
- N-acetylornithine carbamoyltransferase
|
|
|
2.1.4: Amidino |
- Arginine:glycine amidinotransferase
|
|
- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
- Metabolism: amino acid metabolism
- neurotransmitter enzymes
|
|
monoamine |
histidine → histamine |
anabolism: |
|
|
catabolism: |
- Histamine N-methyltransferase
- Amine oxidase
|
|
|
tyrosine→dopamine→epinephrine |
anabolism: |
- Tyrosine hydroxylase
- Aromatic L-amino acid decarboxylase
- Dopamine beta hydroxylase
- Phenylethanolamine N-methyltransferase
|
|
catabolism: |
- Catechol-O-methyl transferase
- Monoamine oxidase
|
|
|
glutamate→GABA |
anabolism: |
|
|
catabolism: |
- 4-aminobutyrate transaminase
|
|
|
tryptophan→serotonin→melatonin |
- Tryptophan hydroxylase
- Aromatic L-amino acid decarboxylase
- Acetylserotonin O-methyltransferase
|
|
|
arginine→NO |
- Nitric oxide synthase (NOS1, NOS2, NOS3)
|
|
choline→Acetylcholine |
anabolism: |
- Choline acetyltransferase
|
|
catabolism: |
- Cholinesterase (Acetylcholinesterase, Butyrylcholinesterase)
|
|
|
|
mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
|
k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
|
m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
|
|
|
|
UpToDate Contents
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English Journal
- QM/MM studies on the catalytic mechanism of Phenylethanolamine N-methyltransferase.
- Hou QQ, Wang JH, Gao J, Liu YJ, Liu CB.SourceKey Lab of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.
- Biochimica et biophysica acta.Biochim Biophys Acta.2012 Apr;1824(4):533-41. Epub 2012 Feb 3.
- Epinephrine is a naturally occurring adrenomedullary hormone that transduces environmental stressors into cardiovascular actions. As the only route in the catecholamine biosynthetic pathway, Phenylethanolamine N-methyltransferase (PNMT) catalyzes the synthesis of epinephrine. To elucidate the detail
- PMID 22326747
- Catecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercise.
- Ghimire LV, Kohli U, Li C, Sofowora GG, Muszkat M, Friedman EA, Solus JF, Wood AJ, Stein CM, Kurnik D.SourceDepartment of Medicine, Division of Clinical, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
- Pharmacogenetics and genomics.Pharmacogenet Genomics.2012 Apr;22(4):254-60.
- OBJECTIVE: To examine the hypothesis that genetic variation in enzymes and transporters associated with synthesis, storage, release, and metabolism of catecholamines contributes to the interindividual variability in plasma catecholamine concentrations at rest and after exercise.METHODS: We measured
- PMID 22258110
Japanese Journal
- 酵素関係(アイソザイムを含む) フェニルエタノラミンN-メチルトランスフェラーゼ (広範囲 血液・尿化学検査,免疫学的検査(第7版・1)その数値をどう読むか) -- (生化学的検査(1))
- Immunohistochemical studies on supporting and chromaffin cells in the Chinese hamster adrenal medulla in the prehibernating season
- Suzuki Takao,Wan Li Xiang
- 青森県立保健大学紀要 3(1), 121-123, 2002-03
- … Cryostat sections fixed with 4% paraformaldehyde or Zamboni fluid were immuno stained by the labelled streptavidin biotin (LSAB) method using antisera to S-100 protein and phenylethanolamine N-methyltransferase (PNMT). … PNMT-immunoreactive cells (adrenaline (A) cells) were observed mainly in central regions, and PNMT-immunonegative cells (noradrenaline (NA) cells) chiefly in peripheral regions of the adrenal medulla. …
- NAID 110000953459
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★リンクテーブル★
[★]
- 英
- phenylethanolamine N-methyltransferase PNMT
- 同
- フェニルエタノールアミンN-メチル基転移酵素、ノルアドレナリンN-メチルトランスフェラーゼ ノルアドレナリンN-メチル基転移酵素 noradrenaline N-methyltransferase
[★]
結節性多発動脈炎 polyarteritis nodosa