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- 1. クループ：薬剤および補助治療 croup pharmacologic and supportive interventions
- 2. 慢性炎症性脱髄性多発神経炎：治療および予後 chronic inflammatory demyelinating polyneuropathy treatment and prognosis
- 3. 関節リウマチに対する非生物学的DMARD併用のランダム化臨床試験 randomized clinical trials of combinations of nonbiologic dmards in rheumatoid arthritis
- 4. アルコール性肝炎：自然経過およびマネージメント alcoholic hepatitis natural history and management
- 5. 小児における喘息の急性増悪：救急外来によるマネージメント acute asthma exacerbations in children emergency department management
English Journal
- Quantitative LC-MS determination of liposomal encapsulated prednisolone phosphate and non-encapsulated prednisolone concentrations in murine whole blood and liver tissue.
- Smits EA1, Soetekouw JA2, van Doormalen I3, van den Berg BH3, van der Woude MP3, de Wijs-Rot N3, Vromans H4.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2015 Nov 10;115:552-61. doi: 10.1016/j.jpba.2015.07.012. Epub 2015 Jul 26.
- The underlying pharmacokinetic profile of liposomal drug delivery systems is not yet fully known. This is primarily due to a lack of suitable quantitative bioanalytical methodology to simultaneously determine separate liposomal-encapsulated and non-encapsulated drug tissue concentrations in complex
- PMID 26319748
- [(18)]F FDG PET/CT imaging to monitor the therapeutic effect of liposome-encapsulated prednisolone in experimental rheumatoid arthritis.
- van der Geest T1, Metselaar JM2, Gerrits D3, van Lent PL4, Storm G5, Laverman P6, Boerman OC7.
- Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2015 Jul 10;209:20-6. doi: 10.1016/j.jconrel.2015.04.019. Epub 2015 Apr 19.
- Current treatment of rheumatoid arthritis includes systemic administration of glucocorticoids. To improve joint targeting and anti-inflammatory efficacy these glucocorticoids are encapsulated in long-circulating liposomes. The present study aimed to monitor therapeutic effects of prednisolone (PLP)-
- PMID 25902038
- Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy.
- Lobatto ME1, Calcagno C2, Otten MJ2, Millon A3, Ramachandran S2, Paridaans MP2, van der Valk FM4, Storm G5, Stroes ES4, Fayad ZA2, Mulder WJ1, Metselaar JM6.
- Nanomedicine : nanotechnology, biology, and medicine.Nanomedicine.2015 Jul;11(5):1133-40. doi: 10.1016/j.nano.2015.02.020. Epub 2015 Mar 17.
- The present study describes the development of a good manufacturing practice (GMP)-grade liposomal nanotherapy containing prednisolone phosphate for the treatment of inflammatory diseases. After formulation design, GMP production was commenced which yielded consistent, stable liposomes sized 100nm±
- PMID 25791805
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