関: Penicillin-binding proteins

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1. β-ラクタム系抗生物質：作用機序、耐性および有害作用beta lactam antibiotics mechanisms of action and resistance and adverse effects [show details]
…penicillin (or other beta-lactams) and hence have been called penicillin binding proteins (PBPs). Different PBPs appear to serve different functions for the bacterial cell. As an example, PBP2 in Escherichia …
2. メチシリン耐性黄色ブドウ球菌（MRSA）：微生物学methicillin resistant staphylococcus aureus mrsa microbiology [show details]
…contrast with the other four PBPs (1-4), PBP2a has a low affinity for beta-lactam antibiotics. In susceptible staphylococcal isolates, the beta-lactams covalently bind to PBPs 1-3, thereby inactivating …
3. 劇症型溶血性レンサ球菌感染症と毒素ショック症候群：治療および予防invasive group a streptococcal infection and toxic shock syndrome treatment and prevention [show details]
…of penicillin-binding proteins (PBPs) on the organism surface that are available at various points during the phases of bacterial growth. In one in vitro study, fewer PBPs were observed during stationary-phase …
4. 人工弁心内膜炎における抗菌療法antimicrobial therapy of prosthetic valve endocarditis [show details]
…bactericidal effect by facilitating expanded binding to the cell membrane penicillin-binding proteins (PBPs) . However, dual beta-lactam therapy may not provide synergistic bactericidal activity against Enterococcus …

English Journal

Synthesis and Kinetic Analysis of Two Conformationally Restricted Peptide Substrates of Escherichia coli Penicillin-Binding Protein 5.

Nemmara VV1, Nicholas RA2, Pratt RF1.
Biochemistry.Biochemistry.2016 Jul 26;55(29):4065-76. doi: 10.1021/acs.biochem.6b00576. Epub 2016 Jul 15.
Escherichia coli PBP5 (penicillin-binding protein 5) is a dd-carboxypeptidase involved in bacterial cell wall maturation. Beyond the C-terminal d-alanyl-d-alanine moiety, PBP5, like the essential high-molecular mass PBPs, has little specificity for other elements of peptidoglycan structure, at least
PMID 27420403

Gypsy moth pheromone-binding protein-ligand interactions: pH profiles and simulations as tools for detecting polar interactions.

Sanes JT1, Plettner E2.
Archives of biochemistry and biophysics.Arch Biochem Biophys.2016 Jul 16;606:53-63. doi: 10.1016/j.abb.2016.07.008. [Epub ahead of print]
Pheromone-binding proteins (PBPs) are believed to control diffusion of pheromones in sensory hairs of insects. The interactions of gypsy moth (Lymantria dispar) PBPs with the sex attractant pheromone, (+)-Disparlure ((7R,8S)-epoxy-2-methyloctadecane), and the enantioselectivity of recognition are no
PMID 27431057

Promoter Identification and Transcription Analysis of Penicillin-Binding Protein Genes in Streptococcus pneumoniae R6.

Peters K1, Pipo J1, Schweizer I1, Hakenbeck R1, Denapaite D1.
Microbial drug resistance (Larchmont, N.Y.).Microb Drug Resist.2016 Jul 13. [Epub ahead of print]
Penicillin-binding proteins (PBPs) are membrane-associated enzymes, which are involved in the last two steps of peptidoglycan biosynthesis, and some of them are key players in cell division. Furthermore, they are targets of β-lactams, the most widely used antibiotics. Nevertheless, very little is k
PMID 27409661

Japanese Journal

Detection and analysis of <i>Lactobacillus paracasei</i> penicillin-binding proteins revealed the presence of cholate-sensitive penicillin-binding protein 3 and an elongated cell shape in a cholate-sensitive strain

Bioscience of Microbiota, Food and Health, 2016
NAID 130005285678

Both the transglycosylase and transpeptidase functions in plastid penicillin-binding protein are essential for plastid division in <i>Physcomitrella patens</i>