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English Journal
- Pregnancy and lactation differentially modify the transcriptional regulation of steroidogenic enzymes through DNA methylation mechanisms in the hippocampus of aged rats.
- Rossetti MF1, Varayoud J2, Lazzarino GP3, Luque EH4, Ramos JG5.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2016 Jul 5;429:73-83. doi: 10.1016/j.mce.2016.03.037. Epub 2016 Apr 1.
- In the present study, we examined the mRNA expression and DNA methylation state of steroidogenic enzymes in the hippocampus of young adult (90-days-old) and middle-aged (450-days-old) nulliparous rats, and middle-aged multiparous rats subjected to three pregnancies with and without lactation. Aging
- PMID 27040308
- Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test.
- Muth-Köhne E1, Westphal-Settele K2, Brückner J2, Konradi S2, Schiller V3, Schäfers C4, Teigeler M4, Fenske M5.
- Aquatic toxicology (Amsterdam, Netherlands).Aquat Toxicol.2016 Jul;176:116-27. doi: 10.1016/j.aquatox.2016.04.018. Epub 2016 Apr 20.
- The Fish Sexual Development Test (FSDT) is a non-reproductive test to assess adverse effects of endocrine disrupting chemicals. With the present study it was intended to evaluate whether gene expression endpoints would serve as predictive markers of endocrine disruption in a FSDT. For proof-of-conce
- PMID 27130971
- Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors.
- Di Matteo M1, Ammazzalorso A1, Andreoli F2, Caffa I3, De Filippis B1, Fantacuzzi M1, Giampietro L1, Maccallini C1, Nencioni A3, Parenti MD4, Soncini D3, Del Rio A5, Amoroso R1.
- Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2016 Jul 1;26(13):3192-4. doi: 10.1016/j.bmcl.2016.04.078. Epub 2016 Apr 28.
- The most frequently used treatment for hormone receptor positive breast cancer in post-menopausal women are aromatase inhibitors. In order to develop new aromatase inhibitors, we designed and synthesized new imidazolylmethylpiperidine sulfonamides using the structure of the previously identified aro
- PMID 27161804
Japanese Journal
- Seasonal Changes in Spermatogenesis and Immunolocalization of Cytochrome P450 17α-Hydroxylase/c17-20 Lyase and Cytochrome P450 Aromatase in the Wild Male Ground Squirrel (Citellus dauricus Brandt)
- ZHANG Haolin,SHENG Xia,HU Xiao,LI Xiuwen,XU Hui,ZHANG Mengyuan,LI Ben,XU Meiyu,WENG Qiang,ZHANG Zhixiang,TAYA Kazuyoshi
- The Journal of reproduction and development 56(3), 297-302, 2010-06-01
- … The purpose of this study was to investigate seasonal changes of spermatogenesis and the cellular localization of P450c17 and P450arom in wild male ground squirrels during the breeding and non-breeding seasons. … In addition, total proteins were extracted from testicular tissue in the breeding and non-breeding seasons and were used for Western blotting analysis for P450c17 and P450arom. …
- NAID 10026434084
- Localization of Five Steroidogenic Enzyme mRNAs in Japanese Black Bear (Ursus thibetanus japonicus) Testes During the Mating Season by In Situ Hybridization
- IIBUCHI Ruriko,SHIMOZURU Michito,KAMINE Akari,NIO KOBAYASHI Junko,IWANAGA Toshihiko,TSUBOTA Toshio
- The Journal of reproduction and development 56(2), 236-242, 2010-04-01
- … In the present study, we clarified the mRNA sequence of 5 steroidogenic enzymes (P450scc, 3βHSD, P450c17, 17βHSD3 and P450arom) using RT-PCR and RACE methods and the localization of these gene expressions in the bear testis using an in situ hybridization technique. … P450arom mRNAs were distributed in the seminiferous tubules. …
- NAID 10026324479
- Secretion of Inhibin during the Estrous Cycle in the Female Asian Elephant (Elephas maximus)
- KAEWMANEE Saroch,WATANABE Gen,KISHIMOTO Miori,JIN Wan Zhu,YAMAMOTO Yuki,YAMAMOTO Tatsuya,NARUSHIMA Etsuo,KOMIYA Teruyuki,TAYA Kazuyoshi
- Journal of Veterinary Medical Science advpub(0), 1008230322, 2010
- … To define the source of circulating inhibin of female Asian elephants, the immunolocalizations of inhibin α, βA, and βB subunits, 3β-hydroxysteroid dehydrogenase (3β-HSD), aromatase cytochrome P450 (P450arom) and cytochrome 17α-hydroxylase P450 (P450 c17) were investigated. … Immunolocalization of inhibin subunits, 3β-HSD, P450arom and P450c17 were detected in granulosa cells of antral follicles and luteal cells. …
- NAID 40018701686
Related Links
- P450arom:アロマターゼ (aromatase) 17β-HSD: 17β-ヒドキシステロイド脱水素酵素 ステロイドホルモン ステロイド核をもつホルモンをステロイドホルモンと呼ぶ。副腎、精巣、卵巣等の内分泌器官より分泌される。特に脳で合成される 細胞膜や ...
- シチメンチョウ、アヒルおよびガチョウの孵化後1週齢以内の生殖腺におけるP450arom、AMHおよびERα mRNA発現 (p.220-226) 木庭尚美、大藤利通、河ヨンジュ、水島秀成、塚田光、齋藤昇、島田清司 名古屋大学大学院 生命農学研究科 ...
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