WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

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Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis.

Jenkins MA1, Dowty JG2, Ait Ouakrim D2, Mathews JD2, Hopper JL2, Drouet Y2, Lasset C2, Bonadona V2, Win AK2.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.J Clin Oncol.2015 Feb 1;33(4):326-31. doi: 10.1200/JCO.2014.55.8536. Epub 2014 Dec 22.
PURPOSE: For carriers of germline mutations in DNA mismatch repair genes, the most relevant statistic for cancer prevention is colorectal cancer (Lynch syndrome) risk, particularly in the short term.METHODS: We conducted a meta-analysis of all independent published Lynch syndrome studies reporting a
PMID 25534380

Characterization of complementary determinant region 3δ in human MutS homologue 2-specific γδ T cells.

Chen H1, Ji X, Cui L, Zhang J, He W.
Scandinavian journal of immunology.Scand J Immunol.2015 Feb;81(2):121-8. doi: 10.1111/sji.12256.
γδT cells function as sentinels in early host responses to infections and malignancies. Previously, we found ectopically expressed human MutS homologue 2 (hMSH2), recognized by γδT cells, triggered a γδT cell-mediated cytolysis to tumor cells. However, the characteristics of hMSH2-specific γ�
PMID 25410477

Down-regulation of MSH2 expression by Hsp90 inhibition enhances cytotoxicity affected by tamoxifen in human lung cancer cells.

Ko JC1, Chiu HC2, Syu JJ2, Chen CY2, Jian YT2, Huang YJ2, Wo TY2, Jian YJ2, Chang PY2, Wang TJ2, Lin YW3.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Jan 2;456(1):506-12. doi: 10.1016/j.bbrc.2014.11.116. Epub 2014 Dec 6.
The anti-estrogen tamoxifen has been used worldwide as an adjuvant hormone therapeutic agent in the treatment of breast cancer. However, the molecular mechanism of tamoxifen-induced cytotoxicity in non-small cell lung cancer (NSCLC) cells has not been identified. Human MutS homolog 2 (MSH2), a cruci
PMID 25490383