Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/04/02 22:55:39」(JST)
[Wiki en表示]
Cefoxitin
|
Clinical data |
Trade names |
Mefoxin |
AHFS/Drugs.com |
Monograph |
MedlinePlus |
a682737 |
Pregnancy
category |
|
Routes of
administration |
IV |
ATC code |
|
Pharmacokinetic data |
Metabolism |
minimal |
Biological half-life |
41-59 min |
Excretion |
85% urine |
Identifiers |
IUPAC name
- (6S,7R)-3-(carbamoyloxymethyl)-7-methoxy-
8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-
1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
|
CAS Number |
|
PubChem CID |
|
DrugBank |
|
ChemSpider |
|
UNII |
|
KEGG |
|
ChEBI |
|
ChEMBL |
|
ECHA InfoCard |
100.047.841 |
Chemical and physical data |
Formula |
C16H17N3O7S2 |
Molar mass |
427.454 g/mol |
3D model (Jmol) |
|
SMILES
-
O=C2N1/C(=C(\CS[C@@H]1[C@]2(OC)NC(=O)Cc3sccc3)COC(=O)N)C(=O)O
|
InChI
-
InChI=1S/C16H17N3O7S2/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22)/t14-,16+/m1/s1 Y
-
Key:WZOZEZRFJCJXNZ-ZBFHGGJFSA-N Y
|
NY (what is this?) (verify) |
Cefoxitin is a second-generation cephamycin antibiotic developed by Merck & Co., Inc., often grouped with the second−generation cephalosporins. It is sold under the brand name Mefoxin.
Microbiology
Cefoxitin acts by interfering with cell wall synthesis. Its activity spectrum includes a broad range of gram-negative and gram-positive bacteria including anaerobes. It is inactive in vitro to most strains of Pseudomonas aeruginosa and many strains of Enterobacter cloacae. Staphylococci resistant to methicillin/oxacillin should be considered resistant to cefoxitin.[1]
Cefoxitin is considered to be a strong beta-lactamase inducer, as are certain other antibiotics (such as imipenem).[2]
Spectrum of Bacterial Susceptibility
Cefoxitin has a broad spectrum of activity and has been used in the treatment of skin, bone, respiratory and urinary tract infections. Susceptible bacteria include some Staphylococci, Enterococci, Streptococci, and others. The following represents MIC susceptibility data for a few medically significant microorganisms.
- Escherichia coli: 0.2 μg/ml – 64 μg/ml
- Haemophilus influenzae: 0.5 μg/ml – 12.5 μg/ml
- Streptococcus pneumoniae: 0.2 μg/ml – 1 μg/ml
[3]
References
- ^ Mefoxin Official FDA information at Drugs.com
- ^ Phillips I, Shannon K (1993). "Importance of beta-lactamase induction". Eur J Clin Microbiol Infect Dis. 12 Suppl 1: S19–26. PMID 8477758.
- ^ http://www.toku-e.com/Assets/MIC/Cefoxitin.pdf
Antibacterials: cell envelope antibiotics (J01C-J01D)
|
|
Intracellular |
- Inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
|
|
Glycopeptide |
- Inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
|
|
β-lactams/
(inhibit PBP
cross-links) |
|
|
Other |
- polymyxins/detergent
- depolarizing
- Hydrolyze NAM-NAG
- Tyrothricin
- Isoniazid
- Teixobactin
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Phenotypic detection of mecC-MRSA: cefoxitin is more reliable than oxacillin.
- Skov R, Larsen AR, Kearns A, Holmes M, Teale C, Edwards G, Hill R.Author information Department of Microbiology and Infection Control, Statens Serum Institut, Artillerivej 5, Copenhagen 2300, Denmark.AbstractOBJECTIVES: To investigate the reliability of cefoxitin and oxacillin for the detection of mecC-positive Staphylococcus aureus.
- The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2014 Jan;69(1):133-5. doi: 10.1093/jac/dkt341. Epub 2013 Sep 12.
- OBJECTIVES: To investigate the reliability of cefoxitin and oxacillin for the detection of mecC-positive Staphylococcus aureus.METHODS: The susceptibility to cefoxitin and oxacillin of 62 mecC-positive S. aureus isolates was investigated using broth microdilution, agar dilution, Etest and disc diffu
- PMID 24038776
- Fourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria.
- Wybo I, Van den Bossche D, Soetens O, Vekens E, Vandoorslaer K, Claeys G, Glupczynski Y, Ieven M, Melin P, Nonhoff C, Rodriguez-Villalobos H, Verhaegen J, Piérard D.Author information Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090 Brussels, Belgium.AbstractOBJECTIVES: To collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous Belgian multicentre studies.
- The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2014 Jan;69(1):155-61. doi: 10.1093/jac/dkt344. Epub 2013 Sep 5.
- OBJECTIVES: To collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous Belgian multicentre studies.METHODS: Four hundred and three strict anaerobic clinical isolates were prospectively collec
- PMID 24008826
Related Links
- Thesaurus Antonyms Related Words Synonyms Legend: Noun 1. Mefoxin - one of several broad spectrum antibiotic substances obtained from fungi and related to penicillin (trade names Mefoxin); addition of side chains has produced ...
- Mefoxin official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. ... Clinical Pharmacology Following an intravenous dose of 1 gram of cefoxitin, serum ...
Related Pictures
★リンクテーブル★
[★]
- 関
- cefoxitin
- 同
- Mefoxin