Inhibition of TAK1 by kamebakaurin in dendritic cells.
Kim JY, Kim HS, Kim YJ, Lee HK, Kim JS, Kang JS, Hong JT, Kim Y, Hwang BY, Han SB.SourceCollege of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, South Korea.
International immunopharmacology.Int Immunopharmacol.2012 Nov 15. pii: S1567-5769(12)00324-4. doi: 10.1016/j.intimp.2012.11.004. [Epub ahead of print]
Kamebakaurin (KA) has anti-cancer and anti-inflammatory activities through direct inhibition of DNA-binding activity of nuclear factor-kappa B (NF-κB) p50. We suggest here another molecular target of KA by the use of lipopolysaccharide-treated dendritic cells. In cell- and enzyme-based assays, KA d
Mechanisms in decorin regulation of vascular endothelial growth factor-induced human trophoblast migration and acquisition of endothelial phenotype.
Lala N, Girish GV, Cloutier-Bosworth A, Lala PK.SourceDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Extravillous trophoblast (EVT) cells of the human placenta invade the uterine decidua and utero-placental arteries to establish an efficient exchange of key molecules between maternal and fetal blood. Trophoblast invasion is stringently regulated in situ both positively and negatively by a variety o
The protein kinase CK2 inhibitor TBB mediates up-regulation of MEK3/6 and p38δ activities, down-regulation of ERK1/2 activity and induction of G1/S arrest in normal human epidermal autocrine proliferating keratinocytes
ISAEVA Antonia Rumenova,MITEV Vanyo Ivanov
Journal of dermatological science 63(2), 124-126, 2011-08-01
Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes
Protein, molecular pathway, molecule, protein kinase ... Mek3 is phosphorylated by several MAPK kinase kinases (MAPKKKs) including Mekk3, Mekk4/Mtk1 (MAP three kinase 1), Mlk3 (Mixed lineage kinase-3), Ask1 (Apoptosis ...
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