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a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus

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ビールス,ろ過性病原体

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/03 05:02:13」(JST)

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Lebombo virus (LEBV) is an orbivirus that infects vertebrates and culicine mosquitoes, thought to be its arthropod vector. It is classified in the genus Orbivirus and the family Reoviridae. It is studied at biosafety level 2.^[1]

Virion

The Lebombo virus virion is a non-enveloped double layer capsid with a diameter of approximately 80 nm for the outer capsid and 60 nm for the inner capsid. The genome it contains is 19200 base pairs long, composed of linear double-stranded RNA in 10 segments. Each virion contains only one genome segment.^[1] The genome codes for 11 proteins total.^[2]

Replication

In Vero cells and LLC-MK2 cells, Lebombo virus causes lysis; however, it does not cause any cytopathic effect in C6/36 cells. It causes disease in mice.^[2]

Transmission

LEBV is thought to be transmitted by mosquitoes in the genus Culicoides. However, it may be transmitted transiently via blood meals, rather than actual infection of the mosquito.^[2]

Human disease

One case of Lebombo virus in humans has been reported, in Ibadan, Nigeria. It caused a febrile illness in a child. People with antibodies to Lebombo virus have been found in South Africa and Nigeria.^[2]^[3]

There is one serotype of LEBV (LEBV-1).^[2]

History

Originally isolated in 1956 in Johannesburg, it was first discovered in Aedes circumluteolus, a species of mosquito.^[2]^[4] Since, it has been isolated in Mansonia africa.^[2]

References

^ ^a ^b "ICTVdB Virus Description - 00.060.0.02.013. Lebombo virus". ictvdb.bio-mirror.cn. Retrieved 2015-12-22.
^ ^a ^b ^c ^d ^e ^f ^g Mohd Jaafar, Fauziah; Belhouchet, Mourad; Belaganahalli, Manjunatha; Tesh, Robert B.; Mertens, Peter P. C.; Attoui, Houssam (2014-01-01). "Full-genome characterisation of Orungo, Lebombo and Changuinola viruses provides evidence for co-evolution of orbiviruses with their arthropod vectors". PLOS ONE. 9 (1): e86392. doi:10.1371/journal.pone.0086392. ISSN 1932-6203. PMC 3901712. PMID 24475112.
^ "ArboCat Virus: Lebombo (LEBV)". wwwn.cdc.gov. Retrieved 2015-12-22.
^ "ArboCat Virus: Lebombo (LEBV)". wwwn.cdc.gov. Retrieved 2015-12-22.

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English Journal

Full-genome characterisation of Orungo, Lebombo and Changuinola viruses provides evidence for co-evolution of orbiviruses with their arthropod vectors.

Mohd Jaafar F1, Belhouchet M1, Belaganahalli M1, Tesh RB2, Mertens PP1, Attoui H1.
PloS one.PLoS One.2014 Jan 24;9(1):e86392. doi: 10.1371/journal.pone.0086392. eCollection 2014.
PMID 24475112

Genetic relatedness of two new Orbivirus serogroups: Orungo and Lebombo.

Brown SE1, Morrison HG, Karabatsos N, Knudson DL.
The Journal of general virology.J Gen Virol.1991 May;72 ( Pt 5):1065-72.
PMID 2033390

Arthropod-borne viral infections of man in Nigeria, 1964-1970.

Moore DL, Causey OR, Carey DE, Reddy S, Cooke AR, Akinkugbe FM, David-West TS, Kemp GE.
Annals of tropical medicine and parasitology.Ann Trop Med Parasitol.1975 Mar;69(1):49-64.
During the years 1964 to 1970, 171 arboviruses of 15 different types were isolated from humans in Nigeria. Isolation rates were highest in 1969, and lowest in 1965 and 1967. Monthly arbovirus activity was highest in the rainy season months of June, July and August and lowest in the dry months of Jan
PMID 1124969

「レボンボウイルス」

Lebombo virus
Virus classification
Group:	Group III (dsRNA)
Order:	Unassigned
Family:	Reoviridae
Genus:	Orbivirus
Species:	Lebombo virus

　　[★]

英: Lebombo virus, LEB

「virus」

　　[★] ウイルス

[:0-1] "ICTVdB Virus Description - 00.060.0.02.013. Lebombo virus". ictvdb.bio-mirror.cn. Retrieved 2015-12-22.

[:1-2] ^ ^a ^b ^c ^d ^e ^f ^g Mohd Jaafar, Fauziah; Belhouchet, Mourad; Belaganahalli, Manjunatha; Tesh, Robert B.; Mertens, Peter P. C.; Attoui, Houssam (2014-01-01). "Full-genome characterisation of Orungo, Lebombo and Changuinola viruses provides evidence for co-evolution of orbiviruses with their arthropod vectors". PLOS ONE. 9 (1): e86392. doi:10.1371/journal.pone.0086392. ISSN 1932-6203. PMC 3901712. PMID 24475112.

[3] "ArboCat Virus: Lebombo (LEBV)". wwwn.cdc.gov. Retrieved 2015-12-22.

[4] "ArboCat Virus: Lebombo (LEBV)". wwwn.cdc.gov. Retrieved 2015-12-22.

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案内

Lebombo virus