English Journal
- The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension.
- Ni W1, Fink GD, Watts SW.
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2007 May;321(2):485-91. Epub 2007 Feb 8.
- The highly effective anorexigen (+)-fenfluramine was widely used to control body weight until the association with primary pulmonary hypertension and valvular heart disease. (+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is primarily responsible for the anorexic effect a
- PMID 17289838
- Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves).
- Polo PA1, Reis RO, Cedraz-Mercez PL, Cavalcante-Lima HR, Olivares EL, Medeiros MA, Côrtes WS, Reis LC.
- Brazilian journal of biology = Revista brasleira de biologia.Braz J Biol.2007 Feb;67(1):167-71.
- This study was carried out aiming to reach behavioral and neuropharmacological evidence of the permeability of the blood-brain barrier (BBB) to serotonin systemically administered in quails. Serotonin injected by a parenteral route (250-1000 microg x kg(-1), sc) elicited a sequence of behavioral eve
- PMID 17505765
Japanese Journal
- Pharmacological characterization of presynaptic .ALPHA.-adrenoceptors in the modulation of the 5-hydroxytryptamine release from vascular adrenergic nerves in the rat.
- KAWASAKI Hiromu,TAKASAKI Koichiro
- The Japanese Journal of Pharmacology 42(4), 561-570, 1986
- … The potentiating effect was more pronounced at low frequencies of PNS (4 and 8 Hz), The potentiation of the pressor response to PNS after 5-HT treatment did not occur in the presence of LY53857 (0.01 μM), a selective 5-HT<SUB>2</SUB> … This effect of clonidine was more pronounced in low frequencies of PNS (4 and 8 Hz) and was abolished by LY53857 (0.01 μM). …
- NAID 130000833453
Related Links
- The IUPHAR/BPS Guide to Pharmacology. LY53857 ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ... Database Links CAS Registry ...
- How to Cite Cohen, M. L., Colbert, W. and Wittenauer, L. A. (1985), Receptor specificity of the 5HT 2 receptor antagonist, LY53857. Drug Dev. Res., 5: 313–321 ... LY53857 is a potent antagonist at vascular 5HT 2 receptors that ...
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