English Journal

Diosgenin-induced protection against myocardial ischaemia-reperfusion injury is mediated by mitochondrial KATP channels in a rat model.

Badalzadeh R1, Yousefi B2, Tajaddini A3, Ahmadian N4.
Perfusion.Perfusion.2015 Oct;30(7):565-71. doi: 10.1177/0267659114566064. Epub 2014 Dec 31.
OBJECTIVE: This study was aimed to evaluate the effects of diosgenin on myocardial ischaemia-reperfusion injury and the potential involvement of mitochondrial KATP (mitoKATP) channel and nitric oxide (NO) system blockades in this field.MATERIALS AND METHODS: After isolation of hearts of male Wister
PMID 25552273

Selective TNF-α targeting with Infliximab attenuates impaired oxygen metabolism and contractile function induced by an acute exposure to air particulate matter.

Marchini T1, D'Annunzio V2, Paz ML3, Cáceres L1, Garcés M1, Perez V4, Tasat D5, Vanasco V1, Magnani N1, Gonzalez Maglio D3, Gelpi RJ4, Alvarez S1, Evelson P6.
American journal of physiology. Heart and circulatory physiology.Am J Physiol Heart Circ Physiol.2015 Sep 18:ajpheart.00359.2015. doi: 10.1152/ajpheart.00359.2015. [Epub ahead of print]
Inflammation plays a central role in the onset and progression of cardiovascular diseases associated with the exposure to air pollution particulate matter (PM). The aim of this work was to analyze the cardioprotective effect of selective TNF-α targeting with a blocking anti-TNF-α antibody (Inflixi
PMID 26386109

Estrogen modulation of the ethanol-evoked myocardial oxidative stress and dysfunction via DAPK3/Akt/ERK activation in male rats.

El-Mas MM1, Abdel-Rahman AA2.
Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2015 Sep 15;287(3):284-92. doi: 10.1016/j.taap.2015.06.015. Epub 2015 Jun 23.
Evidence suggests that male rats are protected against the hypotensive and myocardial depressant effects of ethanol compared with females. We investigated whether E2 modifies the myocardial and oxidative effects of ethanol in male rats. Conscious male rats received ethanol (0.5, 1 or 1.5g/kg i.v.) 3
PMID 26111663

Japanese Journal

Product of Heart Rate and First Heart Sound Amplitude as an Index of Myocardial Metabolic Stress During Graded Exercise

Tanaka Hiroaki,Matsuda Takuro,Tobina Takuro,Yamada Yousuke,Yamagishi Tamiharu,Sakai Hideaki,Obara Shigeru,Higaki Yasuki,Kiyonaga Akira,Brubaker Peter H.
Circulation Journal 77(11), 2736-2741, 2013
… Ex1: in all subjects there was a strong correlation between AHS1 and LVdP/dtmax (r=0.94–0.98), and between the DP-AHS1 and the triple product of HR, LVdP/dtmax, and max LVP (r=0.98–0.99). …
NAID 130003361862

Determination of Oxidative Stress and Cardiac Dysfunction after Ischemia/Reperfusion Injury in Isolated Rat Hearts

Inafuku Hitoshi,Kuniyoshi Yukio,Yamashiro Satoshi,Arakaki Katsuya,Nagano Takaaki,Morishima Yuji,Kise Yuya
Annals of Thoracic and Cardiovascular Surgery 19(3), 186-194, 2013
… After I/R, left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (LVEDP), positive maximum left ventricular developing pressure (max LV dP/dt) and coronary flow (CF) were measured. …
NAID 130002148337

Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine.

Akiyama Daiji,Hara Tetsuya,Yoshitomi Osamu,Maekawa Takuji,Cho Sungsam,Sumikawa Koji
Journal of anesthesia 24(4), 575-581, 2010-08-20
… Heart rate (HR), left ventricular developed pressure (LVdP), maximum rate of LVdP (LVdP/dt (max)), LV end-diastolic pressure (LVEDP), percentage of segment shortening (%SS, an index of regional myocardial contractility), and coronary venous interleukin-6 concentration in the LAD perfusion area were measured before ischemic induction and during reperfusion. …
NAID 10026632664