白血球遊走阻止因子 leukocyte migration inhibitory factor

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English Journal

A new means to identify type 3 secreted effectors: functionally interchangeable class IB chaperones recognize a conserved sequence.

Costa SC1, Schmitz AM, Jahufar FF, Boyd JD, Cho MY, Glicksman MA, Lesser CF.Author information 1Division of Infectious Diseases, Department of Medicine (Microbiology and Molecular Genetics), Massachusetts General Hospital and Harvard Medical School, Cambridge, Massachusetts, USA.AbstractMany Gram-negative bacteria utilize specialized secretion systems to inject proteins (effectors) directly into host cells. Little is known regarding how bacteria ensure that only small subsets of the thousands of proteins they encode are recognized as substrates of the secretion systems, limiting their identification through bioinformatic analyses. Many of these proteins require chaperones to direct their secretion. Here, using the newly described protein interaction platform assay, we demonstrate that type 3 secretion system class IB chaperones from one bacterium directly bind their own effectors as well as those from other species. In addition, we observe that expression of class IB homologs from seven species, including pathogens and endosymbionts, mediate the translocation of effectors from Shigella directly into host cells, demonstrating that class IB chaperones are often functionally interchangeable. Notably, class IB chaperones bind numerous effectors. However, as previously proposed, they are not promiscuous; rather they recognize a defined sequence that we designate the conserved chaperone-binding domain (CCBD) sequence [(LMIF)(1)XXX(IV)(5)XX(IV)(8)X(N)(10)]. This sequence is the first defined amino acid sequence to be identified for any interspecies bacterial secretion system, i.e., a system that delivers proteins directly into eukaryotic cells. This sequence provides a new means to identify substrates of type III secretion systems. Indeed, using a pattern search algorithm for the CCBD sequence, we have identified the first two probable effectors from an endosymbiont, Sodalis glossinidius.
mBio.MBio.2012 Feb 14;3(1). pii: e00243-11. doi: 10.1128/mBio.00243-11. Print 2012.
Many Gram-negative bacteria utilize specialized secretion systems to inject proteins (effectors) directly into host cells. Little is known regarding how bacteria ensure that only small subsets of the thousands of proteins they encode are recognized as substrates of the secretion systems, limiting th
PMID 22334517

Tracing the origin of the fungal α1 domain places its ancestor in the HMG-box superfamily: implication for fungal mating-type evolution.

Martin T1, Lu SW, van Tilbeurgh H, Ripoll DR, Dixelius C, Turgeon BG, Debuchy R.Author information 1Department of Plant Biology and Forest Genetics, Uppsala Biocenter, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.AbstractBACKGROUND: Fungal mating types in self-incompatible Pezizomycotina are specified by one of two alternate sequences occupying the same locus on corresponding chromosomes. One sequence is characterized by a gene encoding an HMG protein, while the hallmark of the other is a gene encoding a protein with an α1 domain showing similarity to the Matα1p protein of Saccharomyces cerevisiae. DNA-binding HMG proteins are ubiquitous and well characterized. In contrast, α1 domain proteins have limited distribution and their evolutionary origin is obscure, precluding a complete understanding of mating-type evolution in Ascomycota. Although much work has focused on the role of the S. cerevisiae Matα1p protein as a transcription factor, it has not yet been placed in any of the large families of sequence-specific DNA-binding proteins.
PloS one.PLoS One.2010 Dec 8;5(12):e15199. doi: 10.1371/journal.pone.0015199.
BACKGROUND: Fungal mating types in self-incompatible Pezizomycotina are specified by one of two alternate sequences occupying the same locus on corresponding chromosomes. One sequence is characterized by a gene encoding an HMG protein, while the hallmark of the other is a gene encoding a protein wit
PMID 21170349

Pathophysiological significance of a reaction in mouse gastrointestinal tract associated with delayed-type hypersensitivity.

Yu WG1, Lin P, Pan H, Xiao L, Gong EC, Mei L.Author information 1Department of Physiology, Medical College of Yangtze University, Jingzhou, Hubei Province, China.AbstractAIM: To explore the pathophysiological significance of delayed type hypersensitivity (DTH) reaction in mouse gastrointestinal tract induced by an allergen 2,4-dinitrochlorobenzene (DNCB).
World journal of gastroenterology : WJG.World J Gastroenterol.2004 Aug 1;10(15):2254-8.
AIM: To explore the pathophysiological significance of delayed type hypersensitivity (DTH) reaction in mouse gastrointestinal tract induced by an allergen 2,4-dinitrochlorobenzene (DNCB).METHODS: BALB/c mice were randomly divided into control and DTH(1-6) groups. After sensitized by DNCB smeared on
PMID 15259076

Japanese Journal

アレルギー性薬疹における掻痒感の検討

齋藤幹央,宇野勝次
医療薬学 33(5), 416-423, 2007-05-10
… Regarding leucocyte migration factors (LMFs), there was a signifant difference between the incidence of itching for the leukocyte migration activating factor (LMAF) which was was 82.2% and that for the leukocyte migration inhibitory factor (LMIF) which was 69.2% (p<0.05, Χ^2-test). …
NAID 110006273474

アレルギー性薬疹における掻痒感の検討

齊藤幹央,宇野勝次
医療薬学 33(5), 416-423, 2007
… that for the leukocyte migration inhibitory factor (LMIF) which was 69.2% (p<0.05,χ2-test).In terms of causative drugs,the incidence of itching was 80.2% for antibacterial drugs and 62.5% for non-steroidal antiinflammatory drugs (NSAIDs),the difference again being significant (p<0.02,χ2-test).The detection rate of LMAF was significantly higher than that of LMIF for the antibacterial drugs (p<0.05,χ2-test),but in the case of NSAIDS,the LMIF detection rate was significantly higher than that …
NAID 130004502340

薬剤性出血性大腸炎におけるアレルギー反応の関与 : 白血球遊走試験による検討

齊藤幹央,宇野勝次,柳雅彦,若杉裕
医療薬学 29(5), 581-592, 2003-10-10
… Leukocyte migration activating factor (LMAF) was detected in 5 cases (42%) and leukocyte migration inhibitory factor (LMIF) was detected in 3 cases (25%). … In addition, both LMAF and LMIF may be involved in the pathogenesis. …
NAID 110001166736

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