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For the headcloth worn by Ancient Egyptian Pharaohs, see Khat (apparel). For the village in Azerbaijan, see Hat, Azerbaijan.
| Khat | |
|---|---|
| Catha edulis | |
| Conservation status | |
|
Least Concern (IUCN 2.3) |
|
| Scientific classification | |
| Kingdom: | Plantae |
| (unranked): | Angiosperms |
| (unranked): | Eudicots |
| (unranked): | Rosids |
| Order: | Celastrales |
| Family: | Celastraceae |
| Genus: | Catha |
| Species: | C. edulis |
| Binomial name | |
| Catha edulis (Vahl) Forssk. ex Endl. |
|
| This article contains Ethiopic text. Without proper rendering support, you may see question marks, boxes, or other symbols instead of Ethiopic characters. |
Catha edulis (khat, qat[1]) is a flowering plant native to the Horn of Africa and the Arabian Peninsula. Among communities from these areas, khat chewing has a history as a social custom dating back thousands of years.[2]
Khat contains a monoamine alkaloid called cathinone, an amphetamine-like stimulant, which is said to cause excitement, loss of appetite and euphoria. In 1980, the World Health Organization (WHO) classified it as a drug of abuse that can produce mild-to-moderate psychological dependence (less than tobacco or alcohol),[3] although WHO does not consider khat to be seriously addictive.[2] The plant has been targeted by anti-drug organizations such as the DEA.[4] It is a controlled substance in some countries, such as Canada, Germany, the United Kingdom, and the United States (de facto), while its production, sale, and consumption are legal in other nations, including Djibouti, Ethiopia, Somalia, and Yemen.[5]
Contents
- 1 Nomenclature
- 2 Description
- 3 Cultivation and uses
- 4 Health effects
- 5 Chemistry and pharmacology
- 6 Demographics
- 7 History
- 8 Regulation
- 8.1 Africa
- 8.1.1 Ethiopia
- 8.1.2 Somalia
- 8.1.3 Djibouti
- 8.1.4 Kenya
- 8.1.5 South Africa
- 8.2 Asia
- 8.2.1 China
- 8.2.2 Israel
- 8.2.3 Malaysia
- 8.2.4 Saudi Arabia
- 8.2.5 Yemen
- 8.3 Europe
- 8.3.1 Denmark
- 8.3.2 Finland
- 8.3.3 France
- 8.3.4 Germany
- 8.3.5 Iceland
- 8.3.6 Ireland
- 8.3.7 Netherlands
- 8.3.8 Norway
- 8.3.9 Poland
- 8.3.10 Sweden
- 8.3.11 Switzerland
- 8.3.12 United Kingdom
- 8.4 North America
- 8.4.1 Canada
- 8.4.2 United States
- 8.5 Oceania
- 8.5.1 Australia
- 8.5.2 New Zealand
- 8.6 South America
- 8.1 Africa
- 9 Research programs
- 10 See also
- 11 Notes
- 12 References
- 13 Bibliography
- 14 External links
Nomenclature
Khat goes by various traditional names, such as kat, qat, qaad, ghat, chat, tschat, Abessinischer Tee, Abyssinian Tea, Somali Tea, Arabian Tea, and Kafta in its endemic regions of the Horn of Africa and the Arabian Peninsula.[6][7][1] In the African Great Lakes region, where Catha edulis is in some areas cultivated, it is known as miraa, muhulo and muirungi.[8][9] In South Africa, the plant is known as Bushman's Tea.[10] Other names for khat include Chat Tree and Flower of Paradise.[9]
Description
Khat is a slow-growing shrub or tree that typically attains a height of between 1 and 5 m (3.3 and 16.4 ft). However, it can reach heights of up to 10 metres (33 ft) in equatorial areas. The plant usually grows in arid environments, at a temperature range of 5 to 35 °C (41 to 95 °F).[7] It has evergreen leaves, which are 5–10 cm long and 1–4 cm broad. The shrub's flowers are produced on short axillary cymes that are 4–8 cm in length. Each flower is small, with five white petals. The samara fruit is an oblong, three-valved capsule, which contains one to three seeds.
Cultivation and uses
Khat cultivation in western Yemen near At Tawilah
Qat tree, Yemen
Yemeni eating qat
The khat plant is known by a variety of names, such as qat and gat in Yemen, qaat and jaad in Somalia, and chat in Ethiopia.[2] It is also known as jimma in the Oromo language. Khat has been grown for use as a stimulant for centuries in the Horn of Africa and the Arabian Peninsula. There, chewing khat predates the use of coffee and is used in a similar social context.[2]
Although the practice of khat-chewing is still primarily restricted to its original area of cultivation in the Red Sea area,[2] the khat plant has over the years found its way to Southern Africa as well as tropical areas, where it grows on rocky outcrops and in woodlands. The shrub is today scattered in the KwaZulu-Natal, Eastern Cape, Western Cape and Mpumalanga provinces of South Africa, in addition to Swaziland and Mozambique.[11]
Its fresh leaves and tops are chewed or, less frequently, dried and consumed as tea, to achieve a state of euphoria and stimulation; it also has anorectic side effects. The leaves or the soft part of the stem can be chewed with either chewing gum or fried peanuts to make it easier to chew.
Khat use has traditionally been confined to the regions where it is grown, because only the fresh leaves have the desired stimulating effects. In recent years, however, improved roads, off-road motor vehicles, and air transportation have increased the global distribution of this perishable commodity, and as a result, the plant has been reported in England, Wales, Rome, Amsterdam, Canada, Israel, Australia, New Zealand,[12] and the United States. Traditionally, khat is used as a socialising drug, and this is still very much the case in Yemen, where khat-chewing is predominantly a male habit.[13] Yemenis use traditional costumes and chew the stimulating plant in the afternoons. Chewing khat is also part of the Yemeni business culture to promote decision-making, but foreigners are not expected to participate. Some Yemeni women have their own saloons for the occasion, and participate in chewing khat with their husbands on weekends.
Bundles of khat, seized by the DEA in July 2006
Khat is so popular in Yemen, its cultivation consumes much of the country's agricultural resources. An estimated 40% of the country's water supply goes towards irrigating it,[14] with production increasing by about 10% to 15% every year. One "daily bag" of khat requires an estimated 500 litres (130 US gal) of water to produce.[15] Water consumption is so high, groundwater levels in the Sanaa basin are diminishing, so government officials have proposed relocating large portions of the population of Sana'a to the coast of the Red Sea.[13]
One reason for khat being cultivated in Yemen so widely is the high income it provides for farmers. Some studies done in 2001 estimated that the income from cultivating khat was about 2.5 million Yemeni rials per hectare, while fruits brought only 0.57 million rials per hectare. Between 1970 and 2000, the area on which khat was cultivated was estimated to have grown from 8,000 to 103,000 hectares.[16]
In other countries, outside of its core area of growth and consumption, khat is sometimes chewed at parties or social functions. It may also be used by farmers and labourers for reducing physical fatigue or hunger, and by drivers and students for improving attention. Within the counter-culture segments of the elite population in Kenya, khat (referred to locally as veve or miraa) is used to counter the effects of a hangover or binge drinking, similar to the use of the coca leaf in South America.
It takes seven to eight years for the khat plant to reach its full height. Other than access to sun and water, khat requires little maintenance. Ground water is often pumped from deep wells by diesel engines to irrigate the crops, or brought in by water trucks. The plants are watered heavily starting around a month before they are harvested to make the leaves and stems soft and moist. A good khat plant can be harvested four times a year, providing a year-long source of income for the farmer.
Health effects
Comparison of the perceived harm for 20 popular recreational drugs from a poll among medical psychiatrists specialized in addiction treatment.[17]
Khat consumption induces mild euphoria and excitement, similar to that conferred by strong coffee.[2] Individuals become very talkative under the influence of the plant. The effects of oral administration of cathinone occur more rapidly than the effects of amphetamine pills; roughly 15 minutes as compared to 30 minutes in amphetamine. Khat can induce manic behaviours and hyperactivity, similar in effects to those produced by amphetamine.[18]
The use of khat results in constipation. Dilated pupils (mydriasis) are prominent during khat consumption, reflecting the sympathomimetic effects of the drug, which are also reflected in increased heart rate and blood pressure.
Withdrawal symptoms that may follow occasional use include mild depression and irritability. Withdrawal symptoms that may follow prolonged khat use include lethargy, mild depression, nightmares, and slight tremor. Khat is an effective anorectic (causes loss of appetite). Long-term use can precipitate: negative impact on liver function, permanent tooth darkening (of a greenish tinge), susceptibility to ulcers, and diminished sex drive.
It is unclear if the consumption of khat directly affects the mental health of the user or not.[19] Occasionally, a psychotic episode can result, resembling a hypomanic state in presentation.[20]
Immediate effects:
- increased heart rate, blood pressure[2]
- euphoria[2]
- hyperactivity[18]
Long-term effects:
- depression[2]
- infrequent hallucinations[2]
- impaired inhibition[21] (similar to alcohol)
- increased risk of myocardial infarction (heart attack)[22]
- psychosis in extreme cases in the genetically predisposed[2]
- oral cancer[23][24]
Indeterminate effects:
- death and stroke following acute coronary syndrome (clogging of the artery)[note 1][25]
Chemistry and pharmacology
Cathinone structure
The stimulant effect of the plant was originally attributed to "katin", cathine, a phenethylamine-type substance isolated from the plant. However, the attribution was disputed by reports showing the plant extracts from fresh leaves contained another substance more behaviourally active than cathine. In 1975, the related alkaloid cathinone was isolated, and its absolute configuration was established in 1978. Cathinone is not very stable and breaks down to produce cathine and norephedrine. These chemicals belong to the PPA (phenylpropanolamine) family, a subset of the phenethylamines related to amphetamines and the catecholamines epinephrine and norepinephrine.[19] In fact, cathinone and cathine have a very similar molecular structure to amphetamine.[26] Khat is sometimes confused with methcathinone (also known as cat), a Schedule I substance that possesses a similar chemical structure to the khat plant's cathinone active component. However, both the side effects and the addictive properties of methcathinone are much stronger than those associated with khat use.[27]
When khat leaves dry, the more potent chemical, cathinone, decomposes within 48 hours, leaving behind the milder chemical, cathine. Thus, harvesters transport khat by packaging the leaves and stems in plastic bags or wrapping them in banana leaves to preserve their moisture and keep the cathinone potent. It is also common for them to sprinkle the plant with water frequently or use refrigeration during transportation.
When the khat leaves are chewed, cathine and cathinone are released and absorbed through the mucous membranes of the mouth as well as the lining of the stomach. The action of cathine and cathinone on the reuptake of epinephrine and norepinephrine has been demonstrated in lab animals, showing that one or both of these chemicals cause(s) the body to recycle these neurotransmitters more slowly, resulting in the wakefulness and insomnia associated with khat use.[28]
Receptors for serotonin show a high affinity for cathinone, suggesting this chemical is responsible for feelings of euphoria associated with chewing khat. In mice, cathinone produces the same types of nervous pacing or repetitive scratching behaviours associated with amphetamines.[29] The effects of cathinone peak after 15 to 30 minutes, with nearly 98% of the substance metabolised into norephedrine by the liver.[26]
Cathine is somewhat less understood, being believed to act upon the adrenergic receptors causing the release of epinephrine and norepinephrine.[30] It has a half-life of about three hours in humans. The medication bromocriptine can reduce cravings and withdrawal symptoms within 24 hours.[31]
Demographics
Man in Mogadishu dividing khat into bunches for guests in preparation for a long evening of tea, conversation and chewing
An estimated 10 million people globally use khat on a daily basis.[5] It is grown principally by communities in the Horn of Africa and the Arabian peninsula, where khat-chewing has a long history as a social custom dating back thousands of years.[2]
The traditional form of khat chewing in Yemen involves only male users; khat chewing by females is less formal and less frequent. Researchers estimate about 70–80% of Yemenis between 16 and 50 years old chew khat, at least on occasion. Yemenis spend an estimated 14.6 million person-hours per day chewing khat. Researchers have also estimated that families spend about 17% of their income on khat.[16]
History
According to some sources, khat was first grown in Ethiopia,[32] with the explorer Sir Richard Burton suggesting the plant was later introduced to Yemen from Ethiopia in the 15th century.[33] He specifically mentions the eastern city of Harar as the birthplace of the plant.[34]
Man chewing khat in Sana'a, Yemen (January 2009)
However, amongst communities in the Horn of Africa (Djibouti, Eritrea, Ethiopia, Somalia) and the Arabian Peninsula, khat-chewing has a long history as a social custom dating back thousands of years.[2]
The Ancient Egyptians considered the khat plant a divine food, which was capable of releasing humanity's divinity. The Egyptians used the plant for more than its stimulating effects; they used it for transcending into "apotheosis", with the intent of making the user god-like.[35] Sufis also used it to intensify their mystical experience and to facilitate a sense of union with God.[36][37]
The earliest known documented description of khat is found in the Kitab al-Saidala fi al-Tibb كتاب الصيدلة في الطب, an 11th-century work on pharmacy and materia medica written by Abū Rayhān al-Bīrūnī, a Persian scientist and biologist. Unaware of its origins, al-Bīrūnī wrote that khat is:[38]
[A] commodity from Turkestan. It is sour to taste and slenderly made in the manner of batan-alu. But khat is reddish with a slight blackish tinge. It is believed that batan-alu is red, coolant, relieves biliousness, and is a refrigerant for the stomach and the liver.
In 1854, Malay author Abdullah bin Abdul Kadir noted that the custom of chewing khat was prevalent in Al Hudaydah in Yemen:[39]
You observed a new peculiarity in this city – everyone chewed leaves as goats chew the cud. There is a type of leaf, rather wide and about two fingers in length, which is widely sold, as people would consume these leaves just as they are; unlike betel leaves, which need certain condiments to go with them, these leaves were just stuffed fully into the mouth and munched. Thus when people gathered around, the remnants from these leaves would pile up in front of them. When they spat, their saliva was green. I then queried them on this matter: ‘What benefits are there to be gained from eating these leaves?’ To which they replied, ‘None whatsoever, it’s just another expense for us as we’ve grown accustomed to it’. Those who consume these leaves have to eat lots of ghee and honey, for they would fall ill otherwise. The leaves are known as Kad."
In 1856, English writer Charles Dickens also described the custom of khat chewing in the Horn region and the adjacent Gulf territories, likening it to drinking strong green tea:[1]
And one may sleep well if, during the day, too much kat has not been chewed. The leaves of the drug called kat are the chief source of pleasurable excitement in these districts of East Africa. Botanists, taking the native name for the plant, turn it into Catha edulis, eatable kat. It is much used by the Arabs, to whom it is sent in camel loads, consisting of a number of small parcels, each containing about forty slender twigs, with the leaves attached, carefully, wrapped so as to avoid exposure to the air. These leaves are chewed, and act upon the spirits of those using them, much as a strong dose of green tea acts upon us in Europe, when it acts agreeably. Europeans used to stronger stimulants, are little affected by the use of kat, but among the more temperate Arabs it is so welcome a provocative to good humour, that about two hundred and eighty camel-loads of it are used every year in Aden only.
Regulation
In 1965, the World Health Organization (WHO) Expert Committee on Dependence-producing Drugs' Fourteenth Report noted, "The Committee was pleased to note the resolution of the Economic and Social Council with respect to khat, confirming the view that the abuse of this substance is a regional problem and may best be controlled at that level."[40] For this reason, khat was not scheduled under the Single Convention on Narcotic Drugs. In 1980, the WHO classified the plant as a drug of abuse that can produce mild to moderate psychological dependence (less than tobacco or alcohol),[3] although the WHO does not consider khat to be seriously addictive.[2] It is a controlled or illegal substance in some countries, but is legal for sale and production in others.
Africa
Ethiopia
Khat is legal in Ethiopia.[5]
Somalia
Khat is legal in Somalia.[5]
Djibouti
Khat is legal in Djibouti.[41]
Kenya
Khat is legal in Kenya. However, two of its active components, cathinone and cathine, are classed as Class C substances.[42]
South Africa
In South Africa, Catha edulis is a protected tree.[10]
Asia
China
Khat is illegal in China.[43]
Israel
Khat is consumed mainly by Yemenite Jews. The raw plant is also available for sale in several open markets. A cocktail of Arak and minced frozen khat, mixed with grapefruit juice, has become popular in the south of the country in recent years[citation needed]. However, as of June 2012, the Israeli anti-drug authority announced that beverages containing Khat are considered illegal as per the dangerous drug ordinance of the state of Israel nrg. In 2003, Hagigat, a pill based on extracted cathinone, began to be sold in kiosks in Israel.[44] Following several cases of hospitalisation, the Israeli Ministry of Health classified cathinone as a dangerous drug, and Hagigat was outlawed.[45][46] The plant itself is allowed to be chewed and sold, as no harm was found in normal quantities. Etrogat is a popular juice from Jerusalem sold by Uzi-Eli Hezi and also many variations of Khat juice can be found across Israel.
Malaysia
Khat is illegal in Malaysia.
Saudi Arabia
Khat is illegal in Saudi Arabia.[47]
Yemen
See also: Culture of Yemen
Khat is legal in Yemen.[5] However, cultivation of the crop and the selling of its leaves are governed by a series of regulations. In 2007, the Yemeni government passed a law that restricted the cultivation of khat in a number of agricultural flatlands and basins with high water stress. The Law Concerning the General Sales Tax in 2005 also set the tax rate on khat at 20% of its retail price.[48]
The widespread cultivation of khat in Yemen has exacerbated a severe water shortage in the country. Khat is much more water-intensive to grow than other crops.[49]
Europe
Denmark
Khat has been illegal in Denmark since 1993.[50]
Finland
Khat is classified as an illegal drug in Finland,[51] and possession, use and sale of the substance is prohibited and punishable. As with all illegal drugs, operating a motor vehicle with detectable levels of Khat or its metabolites in one's system can also lead to a conviction for driving under the influence, even if the driver does not appear intoxicated.
France
Khat is prohibited in France as a stimulant.[19]
Germany
In Germany, cathinone is listed as a "non-trafficable substance", which makes the possession, sale and purchase of fresh khat illegal. The derivative cathine is only available on prescription, while norephedrine is not listed.
Iceland
In August 2010 the Icelandic police intercepted khat smuggling for the first time. 37 kg were confiscated. The drugs were most likely intended for sale in Canada.[52] Again in May 2011 the police intercepted around 60 kg.[53]
Ireland
Khat is a controlled drug for the purpose of the Misuse of Drugs Act 1977 and Schedule 1 of the Misuse of Drugs Regulations 1988. As such its unauthorised possession and supply is prohibited.
Netherlands
In the Netherlands, the active ingredients of khat, cathine and cathinone, are qualified as hard drugs and forbidden. Use is mostly limited to the Somali community.[54] In 2008 health minister Ab Klink decided against qualifying the unprocessed plant as drugs after consultation with experts.[55] However, on 9 January 2012 the Dutch government announced a ban on khat.[56]
Norway
In Norway, khat is classified as a narcotic drug and is illegal to use, sell and possess. Most users are Somali immigrants and khat is smuggled from the Netherlands and the UK.[57]
Norwegian Customs seized 10 metric tons of khat in 2010, an increase from less than 4 in 2006.[58]
Poland
In Poland, khat is classified as a narcotic drug, and is illegal to use, sell and possess.[59]
Sweden
The drug was prohibited in Sweden in 1989, without research. [50]
Switzerland
In Switzerland, khat is illegal. It is classified as a narcotic drug.[60]
United Kingdom
Khat was made illegal in the UK on 24 June 2014.[61] Concerns had been expressed by commentators, health professionals and community members about the use of khat in the UK, particularly by immigrants from Somalia, Yemen and Ethiopia.[62][63] Studies of the effects of khat use by immigrants on their mental health suggested that there was a need for better research on khat-chewing and its possible link with psychiatric disorders; it also suggested that public discourse on the issue displayed elements of a moral panic.[63] Some Somali community organisations also campaigned for khat to be banned.[64] As a result of these concerns, the Home Office commissioned successive research studies to look into the matter, and in 2005, presented the question of khat's legal status before the Advisory Council on the Misuse of Drugs. The study concluded that most of the participants who were using khat were using it moderately in terms of both the quantity used and the frequency and duration of chewing sessions, and that khat use was typically a social activity. Only a small minority of the study participants' khat use was judged to be excessive.[65] After a careful review of the evidence, the Advisory Council on the Misuse of Drugs recommended in January 2006 that the status of khat as a legal substance should remain for the time being.[62]
In 2008, Conservative politician Sayeeda Warsi stated that a future Conservative government would ban khat.[66] The website of the Conservative Party, which in 2010 became the larger party in a UK coalition government, previously stated that a Conservative government would "Tackle unacceptable cultural practices by", amongst other measures, "classifying Khat".[67] In 2009, the Home Office commissioned two new studies in the effects of khat use and in June 2010, a Home Office spokesperson stated: "The Government is committed to addressing any form of substance misuse and will keep the issue of khat use under close scrutiny".[68]
During a parliamentary debate on the legality issue on 11 January 2012, Mark Lancaster, the Conservative Member of Parliament for Milton Keynes, stated that the importation of Khat into the UK stands at 10 tonnes every week.[69]
On 23 January 2013, the Advisory Council on the Misuse of Drugs (ACMD) said there was "insufficient evidence" that khat caused health problems. The ACMD said there was "no evidence" khat was directly linked with serious or organised crime, and was chewed to obtain a "mild stimulant effect much less potent than stimulant drugs, such as amphetamine".[70]
On 3 July 2013, the British Home Secretary Theresa May announced that khat was to be banned in Britain, designating it a Class C substance under the Misuse of Drugs Act 1971.[71][72]
Alex Miller, a journalist from the Montreal, Canada-based magazine and television channel Vice, looked into the use of the substance and the potential impact of the ban for BBC nightly current affairs programme Newsnight[73] and for a Vice documentary.[74]
Kenyan MPs appealed to the UK not to "condemn people" by banning the herbal stimulant khat[75]
In March 2014, the United Kingdom House of Commons' Home Affairs Select Committee announced that it would continue to lobby for the UK government not to go through with its intended ban on khat. The committee had shortly before also completed an inquiry and a report recommending that the British authorities refrain from banning the plant.[76]
On 12 May 2014, the House of Lords passed a Motion to Approve the Misuse of Drugs Act 1971 (Designation)(Amendment) (No. 2)(England, Wales and Scotland) Order 2014,[77] in order to control Catha edulis as a Class C drug. An amendment was proposed stating that, "this House regrets that Her Majesty’s Government’s plans for the introduction of the Order do not include provisions for a 12-month review of the impact of the reclassification of khat in view of the highly unusual community focus of its use, for putting a detailed policing strategy in place before a ban takes effect, or for a health strategy to prevent a transfer of addiction to other substances; and do not commit the Department for International Development to do more work with the government of Kenya to alleviate the effect of the reclassification on the Kenyan economy." However, the amendment was defeated by vote.[78] The prohibition came into effect on 24 June 2014.[79]
By January 2015, most khat houses in the UK had closed down operations, and the shops that used to sell the plant stopped doing so. While a few chewers anecdotally asserted that some sellers still offered khat underground, there was only one major seizure since the prohibition, in the Bristol county of Easton in September 2014. Some khat bags were also confiscated in January, but no arrests were made in connection with the seizure. In January 2015, the Avon and Somerset Police reported that it only had to give three people warnings for possession and one person a caution. Additionally, the Somali Resource Centre indicated that the ban seemed to have been effective, and that the prohibition had all but destroyed the import market since the plant has to be fresh in order to be consumed.[80]
North America
Canada
In Canada, khat is a controlled substance under Schedule IV of the Controlled Drugs and Substances Act (CDSA), meaning it is illegal to seek or obtain unless approved by a medical practitioner. Punishment for the possession of khat could lead to a maximum sentence of three years in prison. The maximum punishment for trafficking or possession with the intent of trafficking is ten years in prison.[81]
In 2008, Canadian authorities reported that khat is the most common illegal drug being smuggled at airports.[82]
However, in 2012 the Ontario Court of Appeal upheld a 2011 absolute discharge of a young woman who brought 34 kilograms of khat into Canada in 2009. According to the defence, the ruling recognises that there is no empirical evidence that khat is harmful.[83]
United States
In the United States, cathinone is a Schedule I drug, according to the US Controlled Substance Act. The 1993 DEA rule placing cathinone in Schedule I noted that it was effectively also banning khat:[84]
Cathinone is the major psychoactive component of the plant Catha edulis (khat). The young leaves of khat are chewed for a stimulant effect. Enactment of this rule results in the placement of any material that contains cathinone into Schedule I.
Catha edulis (khat) is a stimulant narcotic that is similar to that of amphetamine and its congeners, not a drug as categorised by US FDA (United States Food & Drug Administration) and FDA import Alert #66-23 (published date 03/18/2011) states that "Districts may detain, without physical examination, all entries of khat",[85] based on section 801(a) (3) of the Federal Food, Drug, and Cosmetic Act on the grounds that "its labeling fails to bear adequate directions for use."
Khat has been seized by local police and federal authorities on several occasions.[86]
The plant itself is specifically banned in Missouri:[87]
Khat, to include all parts of the plant presently classified botanically as catha edulis, whether growing or not; the seeds thereof; any extract from any part of such plant; and every compound, manufacture, salt, derivative, mixture, or preparation of the plant, its seed or extracts.
Oceania
Australia
In Australia, the importation of khat is controlled under the Customs (Prohibited Imports) Regulations 1956. Individual users must obtain permits from the Australian Quarantine and Inspection Service and the Therapeutic Goods Administration to import up to 5 kg per month for personal use.[88] Permits must also be endorsed by the Australian Customs Service which regulates the actual import of the drug.[89] In 2003, the total number of khat annual permits was 294 and the total number of individual khat permits was 202.
Khat is listed as a Schedule 2 dangerous drug in Queensland, in the same category as cannabis.[90] Legality in New South Wales is not clear.[91]
New Zealand
In New Zealand, khat is listed as a Class C drug, in the same category as cannabis and codeine.[92]
South America
In South America, there is no legislation regarding khat; the active ingredients in the plant can be found in several weight control compounds sold on the continent.
Research programs
In 2009, the University of Minnesota launched the Khat Research Program (KRP), a multidisciplinary research and training program[93] focusing on the neurobehavioral and health effects of khat, led by Prof. Dr. Mustafa al'Absi. The program was funded by the National Institutes of Health and the National Institute for Drug Abuse of the United States.[94] The inaugural event for the KRP was held in Sharm El-Sheik, Egypt, in December, 2009[95] in collaboration with the International Brain Research Organization (IBRO) and its local affiliates.
See also
- Betel leaves, a related narcotic herb in Southeast Asia
- Phenylpropanolamine
- List of Southern African indigenous trees
Notes
- ^ either from impaired insight into symptoms by the khat chewer, delay to care, or poorly understood pathophysiological mechanisms
References
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- ^ Simon, O'Rourke (13 December 2006). "Concerns over African methamphetamine-like drug in Hamilton". The New Zealand Herald. Retrieved 12 October 2011.
- ^ a b Kirby, Alex (7 April 2007). "Yemen's khat habit soaks up water". BBC News. Retrieved 26 January 2014.
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Bibliography
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- Hilton-Taylor (1998). Catha edulis. 2006. IUCN Red List of Threatened Species. IUCN 2006. www.iucnredlist.org. Retrieved on 12 May 2006.
- Sahal Abdulle (2 January 2007). "Somali Islamists are gone – so 'khat' is back!". Reuters (Mogadishu). Retrieved 26 January 2014.
- Pendell, Dale (2002). Pharmakodynamis: Stimulating Plants, Potions and Herbcraft: Excitantia and Empathogenica. San Francisco: Mercury House.
External links
| Wikimedia Commons has media related to Catha edulis. |
| Look up khat in Wiktionary, the free dictionary. |
| This article's use of external links may not follow Wikipedia's policies or guidelines. Please improve this article by removing excessive or inappropriate external links, and converting useful links where appropriate into footnote references. (June 2011) |
- Khat drug profile The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)
- Politics of Qat – The Role of a Drug in Ruling Yemen (by Peer Gatter. With a literature list on Khat/Qat)
- Haaretz.com: About the Gat Juice Trend in Israel
- The Gat Addiction in Israel Via Yemen
- BBC News: In pictures... growing khat
- Khat Research Program (KRP)
- Drugs.com, Complete Khat Information
- Esquire "High in Hell"
- Erowid: Khat Vault
- BBC News: Getting to grips with khat in Somaliland
- BBC News: Harmless habit or dangerous drug?
- Ethiopian Plant Names[dead link]
- Australian Government: Therapeutic Goods Administration Khat Importation Kit (archived)
- Star Tribune: Dozens Arrested Nationwide in Drug Case[dead link]
- Qat news page – Alcohol and Drugs History Society (ADHS)
- Khat news page (ADHS)
- Seattle arrest – Khat and the Somalian community
- Village Voice article on khat
- Qat cultivation threatening water resources
- Qat, the Cursed Plant in Yemen: Part 1 (Archived at the Wayback machine)
- Qat, the Cursed Plant in Yemen: Part 2 (Archived at the Wayback machine)
- Qat, the Cursed Plant in Yemen: Part 3 (Archived at the Wayback machine)
- Qat, the Cursed Plant in Yemen: Part 4 (Archived at the Wayback machine)
- Qat, the Cursed Plant in Yemen: Part 5 (Archived at the Wayback machine)
- Khat plant photo gallery
- Yemen Times - Part 1: POLITICS OF QAT: Curse or blessing
- Yemen Times - Part 2: POLITICS OF QAT: From Agrarian State to Oil Rentier
- Yemen Times - Part 3: POLITICS OF QAT: QAT POLITICS IN REGIONAL RETROSPECT
- Yemen Times - Part 4: POLITICS OF QAT: THE BRITISH QAT BAN OF 1957/58 IN ADEN
- Yemen Times - Part 5: POLITICS OF QAT: REVOLUTIONARY YEMEN AND THE ISSUE OF QAT
- Yemen Times - Part 6: POLITICS OF QAT: REVOLUTIONARY YEMEN AND THE ISSUE OF QAT
- Yemen Times - Part 7: POLITICS OF QAT: CHANGES IN QAT POLITICS FOLLOWING PRESIDENT SALEH’S ASCENT TO POWER
- Yemen Times - Part 8: POLITICS OF QAT: YEMEN’S UNIFICATION AND QAT (FIRST PART)
- Yemen Times - Part 9: POLITICS OF QAT: YEMEN’S UNIFICATION AND QAT (SECOND PART)
- Yemen Times - Part 10: POLITICS OF QAT: DONOR DEMANDS AND QAT
- Dressler, S.; Schmidt, M. & Zizka, G. (2014). "Catha edulis". African plants – a Photo Guide. Frankfurt/Main: Forschungsinstitut Senckenberg.
UpToDate Contents
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- 1. アンフェタミンおよび合成カチノン（「バスソルト」）による急性中毒 acute amphetamine and synthetic cathinone bath salt intoxication
English Journal
- Cathinone increases body temperature, enhances locomotor activity, and induces striatal c-fos expression in the Siberian hamster.
- Jones S1, Fileccia EL2, Murphy M2, Fowler MJ2, King MV2, Shortall SE2, Wigmore PM2, Green AR2, Fone KC2, Ebling FJ2.Author information 1School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK. Electronic address: joness141@cardiff.ac.uk.2School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.AbstractCathinone is a β-keto alkaloid that is the major active constituent of khat, the leaf of the Catha edulis plant that is chewed recreationally in East Africa and the Middle East. Related compounds, such as methcathinone and mephedrone have been increasing in popularity as recreational drugs, resulting in the recent proposal to classify khat as a Class C drug in the UK. There is still limited knowledge of the pharmacological effects of cathinone. This study examined the acute effects of cathinone on core body temperature, locomotor and other behaviors, and neuronal activity in Siberian hamsters. Adult male hamsters, previously implanted with radio telemetry devices, were treated with cathinone (2 or 5mg/kg i.p.), the behavioral profile scored and core body temperature and locomotor activity recorded by radio telemetry. At the end of the study, hamsters received vehicle or cathinone (5mg/kg) and neuronal activation in the brain was determined using immunohistochemical evaluation of c-fos expression. Cathinone dose-dependently induced significant (p<0.0001) increases in both temperature and locomotor activity lasting 60-90min. Cathinone (2mg/kg) increased rearing (p<0.02), and 5mg/kg increased both rearing (p<0.001) and lateral head twitches (p<0.02). Both cathinone doses decreased the time spent at rest (p<0.001). The number of c-fos immunopositive cells were significantly increased in the striatum (p<0.0001) and suprachiasmatic nucleus (p<0.05) following cathinone, indicating increased neuronal activity. There was no effect of cathinone on food intake or body weight. It is concluded that systemic administration of cathinone induces significant behavioral changes and CNS activation in the hamster.
- Neuroscience letters.Neurosci Lett.2014 Jan 24;559:34-8. doi: 10.1016/j.neulet.2013.11.032. Epub 2013 Nov 25.
- Cathinone is a β-keto alkaloid that is the major active constituent of khat, the leaf of the Catha edulis plant that is chewed recreationally in East Africa and the Middle East. Related compounds, such as methcathinone and mephedrone have been increasing in popularity as recreational drugs, resulti
- PMID 24287379
- Prevalence of cannabis residues in psychiatric patients: a case study of two mental health referral hospitals in Uganda.
- Awuzu EA1, Kaye E2, Vudriko P1.Author information 1Department of Veterinary Pharmacy, Clinics and Comparative Medicine; College of Veterinary Medicine, Animal Resources and Biosecurity-Makerere University, Kampala, Uganda.2Division of Toxicology, Directorate of Government Analytical Laboratory, Kampala, Uganda.AbstractVarious studies have reported that abuse of cannabis is a risk factor for psychosis. The aims of this study were to determine the prevalence of delta 9-tetrahydrocanabinol (Δ(9)-THC), a major metabolite of cannabis, in psychiatric patients in Uganda, and to assess the diagnostic capacity of two referral mental health hospitals to screen patients for exposure to cannabis in Uganda. Socio-demographic characteristics of the patients were collected through questionnaires and review of medical records. Urine samples were collected from 100 patients and analyzed using Δ(9)-THC immunochromatographic kit (Standard Diagnostics(®), South Korea). Seventeen percent of the patients tested positive for Δ(9)-THC residues in their urine. There was strong association (P < 0.05) between history of previous abuse of cannabis and presence of Δ(9)-THC residues in the urine. Alcohol, cocaine, heroin, pethidine, tobacco, khat and kuber were the other substances abused in various combinations. Both referral hospitals lacked laboratory diagnostic kits for detection of cannabis in psychiatric patients. In conclusion, previous abuse of cannabis is associated with occurrence of the residues in psychiatric patients, yet referral mental health facilities in Uganda do not have the appropriate diagnostic kits for detection of cannabis residues as a basis for evidence-based psychotherapy.
- Substance abuse : research and treatment.Subst Abuse.2014 Jan 8;8:1-5. doi: 10.4137/SART.S13254. eCollection 2014.
- Various studies have reported that abuse of cannabis is a risk factor for psychosis. The aims of this study were to determine the prevalence of delta 9-tetrahydrocanabinol (Δ(9)-THC), a major metabolite of cannabis, in psychiatric patients in Uganda, and to assess the diagnostic capacity of two ref
- PMID 24453492
Japanese Journal
- LiDARとQuickbirdのデータを用いた森林植生タイプの分類:－高山市大八賀川流域の事例－
- システム農学 28(4), 115-122, 2012
- NAID 130005074405
- Determination of cathinones and related ephedrines in forensic whole-blood samples by liquid-chromatography-electrospray tandem mass spectrometry
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 879(11), 727-736, 2011-04-01
- NAID 10029518551
- Khat Alters the Phenotype of in vitro-reconstructed Human Oral Mucosa
- Journal of dental research 89(3), 270-275, 2010-03-01
- NAID 10027309228
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