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1. ホスホグリセリン酸キナーゼ欠損症およびホスホグリセリン酸ムターゼ欠損症phosphoglycerate kinase deficiency and phosphoglycerate mutase deficiency [show details]
…Human PGAM is a dimer consisting of different amounts of muscle (MM) isozyme, brain (BB) isozyme, and the intermediate hybrid (MB) isozyme. Inheritance is autosomal recessive. Various distinct point mutations…
2. アスピリン：リウマチ性疾患における作用機序、主な毒性、および使用aspirin mechanism of action major toxicities and use in rheumatic diseases [show details]
…site of aspirin and nonsalicylate NSAID binding . Mammalian cells contain two related but unique isozymes of COX: PG endoperoxide H2 synthase-1 and -2 (COX-1 and COX-2, respectively). Both catalyze the …
3. グリコーゲン代謝のその他の障害：GLUT2欠損症およびアルドラーゼA欠損症other disorders of glycogen metabolism glut2 deficiency and aldolase a deficiency [show details]
…#611881) is a rare GSD associated with hereditary hemolytic anemia. In the glycolytic pathway, three isozymes of aldolase (A, B, and C) are responsible for the conversion of fructose-1,6-biphosphate into g …
4. 家族性アルドステロン症familial hyperaldosteronism [show details]
…the zona fasciculata. Two isozymes of 11-beta-hydroxylase encoded by two genes on chromosome 8 are responsible for the biosynthesis of aldosterone and cortisol : The isozyme in the zona glomerulosa (CYP11B2 …
5. 筋ホスホリラーゼ欠損症（糖原病V型、マッカードル病）myophosphorylase deficiency glycogen storage disease v mcardle disease [show details]
…glycogen have been shortened to approximately 4 glucosyl units. Phosphorylase exists in three distinct isozymes (muscle, liver, and brain), but diseases are only described for muscle and liver . The muscle-specific …

English Journal

Hepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase-type plasminogen activator-NOG mice.

Suemizu H1, Nakamura K, Kawai K, Higuchi Y, Kasahara M, Fujimoto J, Tanoue A, Nakamura M.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.Liver Transpl.2014 Sep;20(9):1127-37. doi: 10.1002/lt.23916. Epub 2014 Aug 4.
PMID 24838399

Functional analysis of the α-1,3-glucan synthase genes agsA and agsB in Aspergillus nidulans: agsB is the major α-1,3-glucan synthase in this fungus.

Yoshimi A1, Sano M, Inaba A, Kokubun Y, Fujioka T, Mizutani O, Hagiwara D, Fujikawa T, Nishimura M, Yano S, Kasahara S, Shimizu K, Yamaguchi M, Kawakami K, Abe K.
PloS one.PLoS One.2013;8(1):e54893. doi: 10.1371/journal.pone.0054893. Epub 2013 Jan 24.
PMID 23365684

Extragonadal seminoma presenting as a large mass in the pelvic cavity without c-kit-activating mutations.

Kuno T1, Shinohara T, Kasahara K, Matsuoka A, Komatsu Y, Naruse K, Watanabe H.
Japanese journal of clinical oncology.Jpn J Clin Oncol.2012 Jul;42(7):650-3. doi: 10.1093/jjco/hys065. Epub 2012 May 11.
PMID 22581924

Japanese Journal

古くて新しいＺｙｍｏｇｒａｐｈｙ　その基礎と臨床　　癌とアルカリフォスファターゼ　ＫａｓａｈａｒａおよびＫａｓａｈａｒａ‐ｖａｒｉａｎｔアイソザイム

波田寿一
生物物理化学 42(2), 103-108, 1998
… その後, FL-羊膜細胞が有する2つのAPIのうちの1つと variant APが同じ性質を有することを明らかにし, 最初の患者の名にちなんで Kasahara isozyme(K.I.)と命名した. …
NAID 130003607153

Effects of androgen and estrogen on DNA synthesis in immature rat prostate.

KUDO HIDEKI,SAKAMOTO SHINOBU,SUGIURA YOSHIE,KAWASAKI TOHRU,NAKAYAMA TOHRU,KASAHARA NORIYUKI,OKAMOTO RYOHEI
Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 20(3), 305-313, 1987
… The prostatic TK isozymes were separated into 3 types by DEAE-cellulose column chromatography, and the activity of the isozyme eluted with buffer alone was markedly increased in T-treated rats, and this isozyme was suggested to be involved in rapid DNA replication because its activity was not affected by deoxycytidine triphosphate (dCTP). …
NAID 110003150056

Cellular localization of alkaline phosphatase isozymes in three human cancer cell lines: Methodological considerations based on electron cytochemical studies.

MIYAYAMA HARUHIKO,TOKUMITSU SHINICHI,NOMURA HIROTSUNE,TAKEYA MOTOHIRO
Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 16(4), 415-430, 1983
… established as monophenotypic to early placental in KMK-2, Kasahara in HeLa S3-5, and Regan isozymes in HeLa S3-10 respectively.<BR>First, it is confirmed that the optimal conditions of the cell fixation, the substrate concentration and the cultured method, as factors which influenced on the electron cytochemical demonstration of alkaline phosphatase should be thoroughly studied cell-line to cell-line in order to accurately interpret the localization of each isozyme concerned.<BR>Second, it is shown that all of the …
NAID 110003149111