JGCT

同: juvenile granulosa cell tumors of the ovary

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/06 08:20:34」(JST)

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Juxtaglomerular cell tumor (JCT, JGCT, also reninoma) is an extremely rare kidney tumour of the juxtaglomerular cells that typically secretes renin. It often causes severe hypertension that is difficult to control, in adults and children, although among causes of secondary hypertension it is rare. It develops most commonly in young adults, but can be diagnosed much later in life. It is generally considered benign, but its malignant potential is uncertain.^[1]

History

Juxtaglomerular cell tumor was first described in 1967 in a paper by Robertson et al., and first named by Kihara et al. in 1968. Since then, approximately 100 case reports have been published.^[2] Karyotyping of a small number of these tumors revealed a common loss of chromosomes 9 and 11.^[1]

Pathology

By hypersecretion of renin, JCT causes hypertension, often severe and usually sustained but occasionally paroxysmal,^[3] and secondary hyperaldosteronism inducing hypokalemia, though the later can be mild despite high renin.^[4] Both of these conditions may be corrected by surgical removal of the tumor.^[5] Asymptomatic cases have been reported.^[2]

Diagnosis

Pre-operatively, hypertension, especially when severe or poorly controlled, combined with evidence of a kidney tumor via imaging or gross examination suggest a JCT. However, other kidney tumors can cause hypertension by secreting renin. JCTs have a variable appearance and have often being misdiagnosed as renal cell carcinomas; dynamic computed tomography is helpful in the differential diagnosis.^[6] Post-operatively, presence of renin granules in pathology specimens differentiates this tumor from renal hemangiopericytoma and other renal tumors.^[7]

Prognosis

JCT often is described as benign, however one case of metastasis has been reported, so its malignant potential is uncertain.^[1] In most cases the tumor is encapsulated.^[8]

References

^ ^a ^b ^c Capovilla M, Couturier J, Molinié V, Amsellem-Ouazana D, Priollet P, Baumert H, Bruneval P, Vieillefond A (March 2008). "Loss of chromosomes 9 and 11 may be recurrent chromosome imbalances in juxtaglomerular cell tumors". Hum. Pathol. 39 (3): 459–62. doi:10.1016/j.humpath.2007.08.010. PMID 18261631.
^ ^a ^b Naoto Kuroda; et al. (2011). "Review of juxtaglomerular cell tumor with focus on pathobiological aspect". Diagnostic Pathology 6: 80. doi:10.1186/1746-1596-6-80. PMC 3173291. PMID 21871063.
^ W. Hanna; et al. (April 2, 1979). "Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension" (PDF). Can Med Assoc J. 120 (8): 957–9. PMC 1819229. PMID 436071.
^ Beaudoin, J.; Périgny M; Têtu B; Lebel M. (2008). "A Patient With A Juxtaglomerular Cell Tumor With Histological Vascular Invasion". Nature Clinical Practice Nephrology (Laval University, Quebec City, QC, Canada.) 4 (8): 458–62. doi:10.1038/ncpneph0890. PMID 18654602.
^ Wong L, Hsu TH, Perlroth MG, Hofmann LV, Haynes CM, Katznelson L (February 2008). "Reninoma: case report and literature review". J. Hypertens. 26 (2): 368–73. doi:10.1097/HJH.0b013e3282f283f3. PMID 18192852.
^ Tanabe; et al. (July 2001). "Dynamic computer tomography is useful in the differential diagnosis of juxtaglomerular cell tumor and renal cell carcinoma.Tanab". Hypertens Res.
^ Martin SA, Mynderse LA, Lager DJ, Cheville JC; Martin; Lager; Cheville (December 2001). "Juxtaglomerular cell tumor: a clinicopathologic study of four cases and review of the literature". Am. J. Clin. Pathol. 116 (6): 854–63. doi:10.1309/B10J-FKQ5-J7P8-WKU4. PMID 11764074.
^ Abbi RK, McVicar M, Teichberg S, Fish L, Kahn E (1993). "Pathologic characterization of a renin-secreting juxtaglomerular cell tumor in a child and review of the pediatric literature". Pediatr Pathol 13 (4): 443–51. doi:10.3109/15513819309048234. PMID 8372029.

English Journal

Juxtaglomerular cell tumor: A morphological, immunohistochemical and genetic study of six cases.

Kuroda N, Maris S, Monzon FA, Tan PH, Thomas A, Petersson FB, Gatalica Z, Ghazalpour A, Bender RP, Grossmann P, Michal M, Svajdler M, Ovcak Z, Hora M, Hes O.SourceDepartment of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi 780-8562, Japan.
Human pathology.Hum Pathol.2012 Aug 29. [Epub ahead of print]
Juxtaglomerular cell tumors (JGCTs) are rare tumors characterized by renin synthesis, hyperaldosteronism and hypertension. A curious immunohistochemical overlap between JGCT and gastrointestinal stromal tumor (GIST) including the expression of vimentin, CD34, CD117, α-smooth muscle actin was previo
PMID 22939575

A rare testicular solid mass in children: Juvenile granulosa cell tumour of testis.

Couture J, Bolduc S.SourceDivision of Urology, Centre Hospitalier Universitaire de Québec (CHUQ), Université Laval, Québec, QC.
Canadian Urological Association journal = Journal de l'Association des urologues du Canada.Can Urol Assoc J.2012 Apr;6(2):E101-3. doi: 10.5489/cuaj.10176.
Juvenile granulosa cell tumour (JGCT) of the testis is a benign neoplasm rarely seen in children. It usually presents as a unilateral scrotal mass and can be associated with genital ambiguity and chromosomal anomalies. Radical orchiectomy is the treatment of choice. We present an infant with a JGCT
PMID 22511424

Japanese Journal

初発時stage Iで再発をきたした卵巣若年性顆粒膜細胞腫(juvenile granulosa cell tumor:JGCT)の1例

小児がん : 小児悪性腫瘍研究会記録 45(1), 41-45, 2008-02-29
NAID 110007171672

傍糸球体細胞腫による二次性高血圧の1例

日本内科学会雑誌 94(6), 1143-1145, 2005-06-10
NAID 10016791768

若年性顆粒膜細胞種 (JGCT) の1例

産と婦 63, 411-415, 1996
NAID 50005342192

Related Pictures

JGCT-0015291 Защита порогов Spec de Forza Motorsport 4 par keryan_jgct JGCT-0015293 Защита порогов jgct nsx | Hondas | Pinterest Honda Civic 1.5 VTi de keryan_jgct dans la

[pmid18261631-1] Capovilla M, Couturier J, Molinié V, Amsellem-Ouazana D, Priollet P, Baumert H, Bruneval P, Vieillefond A (March 2008). "Loss of chromosomes 9 and 11 may be recurrent chromosome imbalances in juxtaglomerular cell tumors". Hum. Pathol. 39 (3): 459–62. doi:10.1016/j.humpath.2007.08.010. PMID 18261631.

[kuroda-2] Naoto Kuroda; et al. (2011). "Review of juxtaglomerular cell tumor with focus on pathobiological aspect". Diagnostic Pathology 6: 80. doi:10.1186/1746-1596-6-80. PMC 3173291. PMID 21871063.

[3] W. Hanna; et al. (April 2, 1979). "Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension" (PDF). Can Med Assoc J. 120 (8): 957–9. PMC 1819229. PMID 436071.

[4] Beaudoin, J.; Périgny M; Têtu B; Lebel M. (2008). "A Patient With A Juxtaglomerular Cell Tumor With Histological Vascular Invasion". Nature Clinical Practice Nephrology (Laval University, Quebec City, QC, Canada.) 4 (8): 458–62. doi:10.1038/ncpneph0890. PMID 18654602.

[pmid18192852-5] Wong L, Hsu TH, Perlroth MG, Hofmann LV, Haynes CM, Katznelson L (February 2008). "Reninoma: case report and literature review". J. Hypertens. 26 (2): 368–73. doi:10.1097/HJH.0b013e3282f283f3. PMID 18192852.

[6] Tanabe; et al. (July 2001). "Dynamic computer tomography is useful in the differential diagnosis of juxtaglomerular cell tumor and renal cell carcinoma.Tanab". Hypertens Res.

[pmid11764074-7] Martin SA, Mynderse LA, Lager DJ, Cheville JC; Martin; Lager; Cheville (December 2001). "Juxtaglomerular cell tumor: a clinicopathologic study of four cases and review of the literature". Am. J. Clin. Pathol. 116 (6): 854–63. doi:10.1309/B10J-FKQ5-J7P8-WKU4. PMID 11764074.

[pmid8372029-8] Abbi RK, McVicar M, Teichberg S, Fish L, Kahn E (1993). "Pathologic characterization of a renin-secreting juxtaglomerular cell tumor in a child and review of the pediatric literature". Pediatr Pathol 13 (4): 443–51. doi:10.3109/15513819309048234. PMID 8372029.

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