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1. 鉄のバランス調節 regulation of iron balance
2. 周期性発熱症候群およびその他の自己炎症性疾患：概要 periodic fever syndromes and other autoinflammatory diseases an overview

English Journal

--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.

Zinngrebe J1,2, Rieser E1, Taraborrelli L1, Peltzer N1, Hartwig T1, Ren H3, Kovács I4, Endres C1, Draber P1, Darding M1, von Karstedt S1, Lemke J1, Dome B5, Bergmann M5, Ferguson BJ3, Walczak H6.
The Journal of experimental medicine.J Exp Med.2016 Nov 14;213(12):2671-2689. Epub 2016 Oct 24.
The linear ubiquitin chain assembly complex (LUBAC), consisting of SHANK-associated RH-domain-interacting protein (SHARPIN), heme-oxidized IRP2 ubiquitin ligase-1 (HOIL-1), and HOIL-1-interacting protein (HOIP), is a critical regulator of inflammation and immunity. This is highlighted by the fact th
PMID 27810922

Insights into the role of iron in immature rat model of hypoxic-ischemic brain injury.

Wang ZW1, Yang LJ1, Ding YX1, Chang YZ2, Cui H1.
Experimental and therapeutic medicine.Exp Ther Med.2016 Sep;12(3):1723-1731. Epub 2016 Jul 26.
This study aimed to investigate the role of iron in the occurrence and development of hypoxic-ischemic brain injury (HIBI) in immature rat models using 3-day-old Sprague Dawley rats. Normal control (NC), hypoxic-ischemic (HI), anemia, HI + ischemia, early iron treatment and late iron treatment group
PMID 27602087

Hypoxia-Induced Iron Accumulation in Oligodendrocytes Mediates Apoptosis by Eliciting Endoplasmic Reticulum Stress.

Rathnasamy G1, Murugan M1, Ling EA1, Kaur C2.
Molecular neurobiology.Mol Neurobiol.2016 Sep;53(7):4713-27. doi: 10.1007/s12035-015-9389-6. Epub 2015 Aug 29.
This study was aimed at evaluating the role of increased iron accumulation in oligodendrocytes and its role in their apoptosis in the periventricular white matter damage (PWMD) following a hypoxic injury to the neonatal brain. In response to hypoxia, in the PWM, there was increased expression of pro
PMID 26319559

菅原克,松本裕一,壁谷昌彦,大西英高,稲見健司,穂積愛美,佐藤敦子,井戸徳子
日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 65(9), 689-693, 2012-09-00
… 分離されたExPECは,毒素(cnf2,cdtIII),付着因子(F17A,afa-8),鉄取込能(iutA,fyuA,irp1,irp2)に関与する遺伝子を保有していた。 …
NAID 120005331952

S1d2-1 Involvement of heme regulatory motif in iron-sensing, ubiquitination and degradation of IRP2(S1-d2: "Dynamical Structures and Signaling Mechanism of Sensor Metalloprotein",Symposia,Abstract,Meeting Program of EABS & BSJ 2006)