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1. 鉄のバランス調節 regulation of iron balance
2. 鉄芽球性貧血の病態生理 pathophysiology of the sideroblastic anemias
3. 先天性および後天性鉄芽球性貧血の原因 causes of congenital and acquired sideroblastic anemias
4. Clinical manifestations and diagnosis of restless legs syndrome in adults

English Journal

A Role for Amyloid Precursor Protein Translation to Restore Iron Homeostasis and Ameliorate Lead (Pb) Neurotoxicity.

Rogers JT1, Venkataramani V2, Washburn C1, Liu Y1, Tummala V1, Jiang H3, Smith A4, Cahill CM1.
Journal of neurochemistry.J Neurochem.2016 May 21. doi: 10.1111/jnc.13671. [Epub ahead of print]
Iron supplementation ameliorates the neurotoxicity of the environmental contaminant Lead (Pb); however, the mechanism remains undefined. Iron is an essential nutrient but high levels are toxic due principally to the catalytic generation of destructive hydroxyl radicals. Using human neuroblastoma SH-
PMID 27206843

Functional Analysis of GLRX5 Mutants Reveals Distinct Functionalities of GLRX5 Protein.

Liu G1, Wang Y1,2, Anderson GJ3, Camaschella C4, Chang Y2, Nie G1.
Journal of cellular biochemistry.J Cell Biochem.2016 Jan;117(1):207-17. doi: 10.1002/jcb.25267.
Glutaredoxin 5 (GLRX5) is a 156 amino acid mitochondrial protein that plays an essential role in mitochondrial iron-sulfur cluster transfer. Mutations in this protein were reported to result in sideroblastic anemia and variant nonketotic hyperglycinemia in human. Recently, we have characterized a Ch
PMID 26100117

Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly.

Shan Y1, Cortopassi G2.
Mitochondrion.Mitochondrion.2016 Jan;26:94-103. doi: 10.1016/j.mito.2015.12.005. Epub 2015 Dec 17.
Mitochondrial iron-sulfur cluster (ISC) biogenesis provides iron-sulfur cofactors to several mitochondrial proteins, but the extent to which ISC biogenesis regulates hematopoiesis has been unclear. The blood disease Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis, and th
PMID 26702583

Japanese Journal

Base Non-specific Acid Ribonuclease from Irpex lacteus, Primary Structure and Phylogenetic Relationships in RNase T_2 Family Enzyme

Watanabe Hideaki,Fauzi Hamid,Iwama Masanori,Onda Tosihisa,Ohgi Kazuko,Irie Masachika
Bioscience, biotechnology, and biochemistry 59(11), 2097-2103, 1995-11-23
Two base non-specific acid RNases (RNase Irp_1 and RNase Irp_2) were purified from a commercial enzyme, "Driselase" (Irpex lacteus) in a homogeneous state on SDS-PAGE by several steps of chromatograph …
NAID 110002677839

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