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1. 鼻炎の概要 an overview of rhinitis

English Journal

Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders.

Bacher I1, Wu B, Shytle DR, George TP.
Expert opinion on pharmacotherapy.Expert Opin Pharmacother.2009 Nov;10(16):2709-21. doi: 10.1517/14656560903329102.
Mecamylamine (Inversine), the first orally available antihypertensive agent launched in the 1950s, is rarely used today for hypertension because of its widespread ganglionic side effects at antihypertensive doses (25 - 90 mg/day). However, more recent clinical studies suggest that mecamylamine is ef
PMID 19874251

Mecamylamine (Inversine): an old antihypertensive with new research directions.

Shytle RD1, Penny E, Silver AA, Goldman J, Sanberg PR.
Journal of human hypertension.J Hum Hypertens.2002 Jul;16(7):453-7.
Mecamylamine (Inversine), the first orally available antihypertensive agent, is now rarely used. Although celebrated in the 1950s, mecamylamine fell out of favour because of its widespread ganglionic side effects at antihypertensive doses (30-90 mg/day). However, recent studies suggest that mecamyla
PMID 12080428

Nicotine induced seizures blocked by mecamylamine and its stereoisomers.

Newman MB1, Manresa JJ, Sanberg PR, Shytle RD.
Life sciences.Life Sci.2001 Oct 19;69(22):2583-91.
Recent genetic research has shown that certain forms of epilepsy may arise from mutations in the genes encoding for the alpha7 and alpha4 neuronal nicotinic acetylcholine receptor (nAChR) ion channels. These receptors are also involved with the induction of nicotine-induced seizures. (+/-)-Mecamylam
PMID 11712662

Related Pictures

Figure 18: INVERSINE AUSF Performance Inversine (Mecamylamine HCI) Structural Inversine Tablets (Targacept), Drug Inversine™ output filters are used to Inversine - Advanced Universal Sine-wave Mecamylamine (Inversine) is a nonselective Figure 17: INVERSINE AUSF Performance