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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/14 05:52:14」(JST)

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1. 卵細胞質内精子注入法 intracytoplasmic sperm injection
2. 男性不妊症の治療 treatment of male infertility
3. 生殖補助医療施行後の妊娠転帰 pregnancy outcome after assisted reproductive technology
4. Use of assisted reproduction in HIV- and hepatitis-infected couples
5. 男性不妊症の評価 evaluation of male infertility

English Journal

Embryo selection strategy in sibling oocytes: A novel approach to measuring the likelihood of single‑embryo transfer using a mouse embryo transfer model.

Xu FQ, Liu R, Ma Y, Liu L, Liang JY, Ma Y.Author information Center of Reproductive Medicine, Tianjin First Central Hospital, Tianjin 300312, P.R. China.AbstractThe present study investigated the effect of embryo transfer on post-implantation development using different fertilization approaches in sibling oocyte procedures. C57BL/6, DBA/2, C3H/HeJ and ICR mice were used at 8-10 weeks of age. Mature oocytes were collected, divided into two groups and fertilized using in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Different numbers of the resulting blastocysts were then transferred into recipients and designated as either: The single embryo transfer (SET) I model (one transferred embryo), the SET II model (six transferred embryos) or the multiple embryo transfer (MET) model (24 transferred embryos). The development efficiency, cell number, number of apoptotic cells in blastocysts, pregnancy efficiency, delivery rate and cumulative pregnancy efficiency were analyzed. IVF-fertilized embryos exhibited higher blastocyst development competence and embryo quality compared with ICSI embryos. The pregnancy and delivery efficiency was not identified to be significantly different between the two SET models, but it was lower in these two models than in the MET model. The cumulative pregnancy efficiency in SET models, calculated using a mathematical equation, was not decreased. In conclusion, embryo quality was shown to be the primary factor in selecting embryos prior to embryo transfer using sibling oocytes. In addition, single blastocyst transfer can be performed in sibling oocytes without compromising cumulative pregnancy rates, independent of the fertilization approach.
Molecular medicine reports.Mol Med Rep.2014 May;9(5):1952-8. doi: 10.3892/mmr.2014.1998. Epub 2014 Feb 28.
The present study investigated the effect of embryo transfer on post-implantation development using different fertilization approaches in sibling oocyte procedures. C57BL/6, DBA/2, C3H/HeJ and ICR mice were used at 8-10 weeks of age. Mature oocytes were collected, divided into two groups and fertil
PMID 24584547

Assessment of sperm hyperactivated motility and acrosome reaction can discriminate the use of spermatozoa for conventional in vitro fertilisation or intracytoplasmic sperm injection: Preliminary results.

Wiser A1, Sachar S, Ghetler Y, Shulman A, Breitbart H.Author information 1IVF Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Sava, Israel.AbstractBasic semen analysis is insufficient for determining the fertility potential. The aim of this study was to determine if hyperactivated motility (HAM) and acrosome reaction (AR) can be useful tests for evaluating semen quality during male infertility evaluations and to help the clinician decide whether regular insemination or intracytoplasmic sperm injection (ICSI) is preferable during in vitro fertilisation. A prospective study was conducted. Patients with normal sperm according to World Health Organization guidelines who underwent IVF treatment and planned regular insemination were asked to participate. A portion of sperm sample was evaluated for HAM and AR on day of ovum pick up. In HAM assessment, 93.3% of patients with increased HAM had a high fertilisation rate compared with 64% in the group without increased HAM (P = 0.059). For the AR evaluation, 91.7% of samples with a low rate of spontaneous AR had a high fertilisation rate compared with 39.3% in the group with a high rate of spontaneous AR (P = 0.004).
Andrologia.Andrologia.2014 Apr;46(3):313-5. doi: 10.1111/and.12068. Epub 2013 Jan 28.
Basic semen analysis is insufficient for determining the fertility potential. The aim of this study was to determine if hyperactivated motility (HAM) and acrosome reaction (AR) can be useful tests for evaluating semen quality during male infertility evaluations and to help the clinician decide wheth
PMID 23356546

The endoplasmic reticulum-mitochondria connection: one touch, multiple functions.

Marchi S1, Patergnani S1, Pinton P2.Author information 1Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Interdisciplinary Center for the Study of Inflammation (ICSI), Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.2Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Interdisciplinary Center for the Study of Inflammation (ICSI), Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy. Electronic address: pnp@unife.it.AbstractThe endoplasmic reticulum (ER) and mitochondria are tubular organelles with a characteristic "network structure" that facilitates the formation of interorganellar connections. The ER and mitochondria join together at multiple contact sites to form specific domains, termed mitochondria-ER associated membranes (MAMs), with distinct biochemical properties and a characteristic set of proteins. The functions of these two organelles are coordinated and executed at the ER-mitochondria interface, which provides a platform for the regulation of different processes. The roles played by the ER-mitochondria interface range from the coordination of calcium transfer to the regulation of mitochondrial fission and inflammasome formation as well as the provision of membranes for autophagy. The novel and unconventional processes that occur at the ER-mitochondria interface demonstrate its multifunctional and intrinsically dynamic nature. This article is part of a Special Issue entitled: Dynamic and ultrastructure of bioenergetic membranes and their components.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Apr;1837(4):461-9. doi: 10.1016/j.bbabio.2013.10.015. Epub 2013 Nov 8.
The endoplasmic reticulum (ER) and mitochondria are tubular organelles with a characteristic "network structure" that facilitates the formation of interorganellar connections. The ER and mitochondria join together at multiple contact sites to form specific domains, termed mitochondria-ER associated
PMID 24211533

Japanese Journal

生殖補助医療がインプリンティング機構に与える影響 (特集胎生期プログラミングと先制医療)

右田王介,秦健一郎
最新医学 70(5), 903-909, 2015-05
NAID 40020473640

Timing of first cleavage of the human embryo predicts a successful pregnancy by assisted reproductive technologies : a retrospective study

Ikeda Chiaki,Fujita Youko,Shitanaka Manami [他]
Journal of mammalian ova research = 日本卵子学会誌 32(1), 49-56, 2015-04
NAID 40020537044

Clinical application of calcium ionophore (A23187) oocyte activation in fertilization failure after ICSI (Mini-Symposium : Reconsideration of the possibility of ICSI : For further improvements of the clinical performance)

Enjoji Mami,Muroi Miki,Takamizawa Satoru [他]
Journal of mammalian ova research = 日本卵子学会誌 32(1), 29-35, 2015-04
NAID 40020537021

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