large almost cosmopolitan genus of evergreen or deciduous shrubs and herbs with often showy yellow flowers; cosmopolitan except tropical lowlands and Arctic or high altitudes and desert regions (同)genus Hypericum
"St John's wort" redirects here. For the flower known in Devon as St John's wort, see Chelidonium majus.
Hypericum perforatum
Scientific classification
Kingdom:
Plantae
Clade:
Tracheophytes
Clade:
Angiosperms
Clade:
Eudicots
Clade:
Rosids
Order:
Malpighiales
Family:
Hypericaceae
Genus:
Hypericum
Section:
Hypericum sect. Hypericum
Species:
H. perforatum
Binomial name
Hypericum perforatum
L.
Hypericum perforatum, known as perforate St John's-wort,[1]common Saint John's wort and St John's wort,[note 1] is a flowering plant in the family Hypericaceae. Although used as a medicinal herb with possible antidepressant activity, high-quality clinical evidence for such effects are still debated. A multitude of randomized controlled clinical trials and meta-analyses demonstrated that H. perforatum extracts are more effective than placebo in the acute treatment of depressive disorders and similarly effective as standard antidepressants[3] however, no H. perforatum drug has been approved by the US Food and Drug Administration.[4] The plant is poisonous to livestock.[5] The primary phytochemical constituents of St John's wort are hyperforin and hypericin.[6]
Contents
1Description
2Taxonomy
2.1Taxonomic history
2.2Phylogeny
2.3Etymology
3Distribution and habitat
4Ecology
4.1Invasive species
5Traditional medicine
6Side effects
7Interactions
7.1Pharmacokinetics
8In vitro research and phytochemicals
9Livestock
9.1Poisoning
9.1.1Diagnosis
9.1.2Photosensitisation
10Chemistry
10.1Detection in body fluids
10.2Chemical constituents
11Research
11.1Antidepressant
11.2Other
12See also
13Notes
14References
15External links
Description
Translucent dots of glandular tissue on the leaves
Perforate St John's wort is a herbaceous perennial plant with extensive, creeping rhizomes. Its reddish stems are erect and branched in the upper section, and can grow up to 1 m (3 ft 3 in) high. The stems are woody near their base and may appear jointed from leaf scars.[7] The branches are typically clustered about a depressed base. It has opposite and stalkless leaves that are narrow and oblong in shape and 1–2 cm (0.39–0.79 in) long.[8] Leaves borne on the branches subtend the shortened branchlets. The leaves are yellow-green in color, with scattered translucent dots of glandular tissue.[9] The dots are conspicuous when held up to the light, giving the leaves the "perforated" appearance to which the plant's Latin name refers. The flowers measure up to 2.5 cm (0.98 in) across, have five petals and sepals, and are colored bright yellow with conspicuous black dots.[10] The flowers appear in broad helicoid cymes at the ends of the upper branches, between late spring and early to mid summer. The cymes are leafy and bear many flowers. The pointed sepals have black glandular dots. The many stamens are united at the base into three bundles. The pollen grains are ellipsoidal.[2] The black and lustrous seeds are rough, netted with coarse grooves.[11]
When flower buds (not the flowers themselves) or seed pods are crushed, a reddish/purple liquid is produced.[12]
Taxonomy
Taxonomic history
The specific epithet perforatum is Latin, referring to the perforated appearance of the plant's leaves.[11]
Phylogeny
It is probable that Hypericum perforatum originated as a hybrid between two closely related species with subsequent doubling of chromosomes. One species is certainly a diploid a subspecies of Hypericum maculatum, either subspecies maculatum or immaculatum. Subspecies maculatum is similar in distribution and hybridizes easily with Hypericum perforatum, but subspecies immaculatum is more similar morphologically. The other parent is most likely Hypericum attenuatum as it possesses the features of Hypericum perforatum that Hypericum maculatum lacks. Though Hypericum maculatum is mostly western in its distribution across Eurasia and Hypericum attenuatum is mostly eastern, both species share distribution in Siberia, where hybridization likely took place. However, the subspecies immaculatum now only occurs in south-east Europe.[13]
Etymology
The common name "St John's wort" may be used to refer to any species of the genus Hypericum. Therefore, Hypericum perforatum is sometimes called "common St John's wort" or "perforate St John's wort" to differentiate it.
St John's wort is named as such because it commonly flowers, blossoms and is harvested at the time of the summer solstice in late June, around St John's Feast Day on 24 June. The herb would be hung on house and stall doors on St John's Feast day to ward off evil spirits and to safeguard against harm and sickness to man and live-stock. The genus name Hypericum is possibly derived from the Greek words hyper (above) and eikon (picture), in reference to the tradition of hanging plants over religious icons in the home during St John's Day.
Distribution and habitat
Hypericum perforatum is native to temperate parts of Europe and Asia, but has spread to temperate regions worldwide as a cosmopolitan invasive weed.[5][14] It was introduced to North America from Europe.[15] The flower occurs in prairies, pastures, and disturbed fields. It prefers sandy soils.[7]
Ecology
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St John's wort reproduces both vegetatively and sexually. It thrives in areas with either a winter- or summer-dominant rainfall pattern; however, distribution is restricted by temperatures too low for seed germination or seedling survival.[5] Altitudes greater than 1500 m, rainfall less than 500 mm, and a daily mean temperature greater than 24 °C are considered limiting thresholds. Depending on environmental and climatic conditions, and rosette age, St John's wort will alter growth form and habit to promote survival. Summer rains are particularly effective in allowing the plant to grow vegetatively, following defoliation by insects or grazing.[16] The seeds can persist for decades in the soil seed bank, germinating following disturbance.[17]
Invasive species
Although Hypericum perforatum is grown commercially in some regions of south east Europe, it is listed as a noxious weed in more than twenty countries and has introduced populations in South and North America, India, New Zealand, Australia, and South Africa.[5][17] In pastures, St John's wort acts as both a toxic and invasive weed. It replaces native plant communities and forage vegetation to the extent of making productive land nonviable[18] or becoming an invasive species in natural habitats and ecosystems. Ingestion by livestock such as horses, sheep, and cattle can cause photosensitization, central nervous system depression, spontaneous abortion or death.[18][19] Effective herbicides for control of Hypericum include 2,4-D, picloram, and glyphosate. In western North America three beetles Chrysolina quadrigemina, Chrysolina hyperici and Agrilus hyperici have been introduced as biocontrol agents.[20]
Full plant
Seedlings
Fruit
Blossom
Traditional medicine
Common St. John's wort has long been used in herbalism and folk medicine.[21] It was thought to have medical properties in classical antiquity and was a standard component of theriacs, from the Mithridate of Aulus Cornelius Celsus' De Medicina (ca. 30 CE) to the Venice treacle of d'Amsterdammer Apotheek in 1686. Folk usages included oily extract ("St. John's oil") and Hypericum snaps. Hypericum perforatum is a common species and is grown commercially for use in herbalism and traditional medicine.[22]
The red, oily extract of H. perforatum has been used in the treatment of wounds for millennia, including by the Knights Hospitaller, the Order of St John, after battles in the Crusades, which is most likely where the name came from.[23][circular reference][21][24] Both hypericin and hyperforin are under study for their potential antibiotic properties.[25]
Side effects
St. John's wort may cause allergic reactions, and can interact in dangerous, sometimes life-threatening ways with a variety of prescribed medicines.[4][21] St John's wort is generally well tolerated, but may cause gastrointestinal discomfort (such as nausea, abdominal pain, loss of appetite, and diarrhea), dizziness, confusion, fatigue, sedation, dry mouth, restlessness, and headache.[26][27][28][29]
The organ systems associated with adverse drug reactions to St John's wort and fluoxetine (an SSRI) have a similar incidence profile;[30] most of these reactions involve the central nervous system.[30] St John's wort also decreases the levels of estrogens, such as estradiol, by accelerating its metabolism, and should not be taken by women on contraceptive pills.[21] St John's wort may cause photosensitivity. This can lead to visual sensitivity to visible and ultraviolet light and to sunburns in situations that would not normally cause them.[26]
Interactions
St. John's wort can interfere with the effects of many prescription medicines, including cyclosporine, digoxin, HIV drugs, cancer medications including irinotecan, and warfarin.[21] Combining both St John's wort and antidepressants could lead to increased serotonin levels causing serotonin syndrome.[31] It should not be taken with the heart medication, ranolazine.[32] Combining estrogen containing oral contraceptives with St John's wort can lead to decreased efficacy of the contraceptive and, potentially, unplanned pregnancies.[33] Consumption of St. John's wort is discouraged for those with bipolar disorder, schizophrenia or dementia.[4]
Pharmacokinetics
St John's wort has been shown to cause multiple drug interactions through induction of the cytochrome P450 enzymes CYP3A4 and CYP1A2. This drug-metabolizing enzyme induction results in the increased metabolism of certain drugs, leading to decreased plasma concentration and potential clinical effect.[34] The principal constituents thought to be responsible are hyperforin and amentoflavone. There is strong evidence that the mechanism of action of these interactions is activation of the pregnane X receptor.[35]
St John's wort has also been shown to cause drug interactions through the induction of the P-glycoprotein efflux transporter. Increased P-glycoprotein expression results in decreased absorption and increased clearance of certain drugs, leading to lower plasma concentrations and impaired clinical efficacy.[36]
Examples of drugs whose effectiveness may be reduced by St. John's wort
For a complete list, see CYP3A4 ligands and CYP2C9 ligands.
In vitro research and phytochemicals
St. John's wort, similarly to other herbs, contains different chemical constituents.[37][38][39] Although St. John's wort is sold as a dietary supplement, there are no standardized manufacturing procedures, and some marketed products may be contaminated with metals, fillers or other impurities.[4]
Comparison of selected chemical constituents of Hypericum perforatum[37][40]
Compound
Conc.[37] [41][42]
log P
PSA
pKa
Formula
MW
CYP1A2 [Note 1]
CYP2C9 [Note 2]
CYP2D6 [Note 3]
CYP3A4 [Note 4]
PGP [Note 5]
t1/2[42] (h)
Tmax[42] (h)
Cmax[42] (mM)
CSS[42] (mM)
Notes/Biological activity[Note 6]
Phloroglucinols (2-5%)
Adhyperforin
0.2-1.9
10-13
71.4
8.51
C36H54O4
550.81
?
?
?
?
?
?
?
?
?
?
Hyperforin
2-4.5
9.7-13
71.4
8.51
C35H52O4
536.78
+
+/-
-
+
+
3.5-16
2.5-4.4
15-235
53.7
-
Naphthodianthrones (0.03-3%)
Hypericin
0.003-3
7.5-10
156
6.9±0.2
C30H16O8
504.44
0
- (3.4 μM)
- (8.5 μM)
- (8.7 μM)
?
2.5-6.5
6-48
0.66-46
?
?
Pseudohypericin
0.2-0.23
6.7±1.8
176
7.16
C30H16O9
520.44
?
?
?
?
?
24.8-25.4
3
1.4-16
0.6-10.8
-
Flavonoids (2-12%)
Amentoflavone
0.01-0.05
3.1-5.1
174
2.39
C30H18O10
538.46
?
- (35 nM)
- (24.3 μM)
- (4.8 μM)
?
?
?
?
?
?
Apigenin
0.1-0.5
2.1±0.56
87
6.63
C15H10O5
270.24
?
?
?
?
?
?
?
?
?
?
Catechin
2-4
1.8±0.85
110
8.92
C15H14O6
290.27
?
?
?
?
?
?
?
?
?
?
Epigallocatechin
?
-0.5-1.5
131
8.67
C15H14O6
290.27
?
?
?
?
?
1.7±0.4a
1.3-1.6a
?
?
?
Hyperoside
0.5-2
1.5±1.7
174
6.17
C21H20O12
464.38
?
?
?
?
?
?
?
?
?
Kaempferol
?
2.1±0.6
107
6.44
C15H10O6
286.24
?
?
?
+/-
?
?
?
?
?
?
Luteolin
?
2.4±0.65
107
6.3
C15H10O6
286.24
-
?
?
?
?
?
?
?
?
?
Quercetin
2-4
2.2±1.5
127
6.44
C15H10O7
302.24
- (7.5 μM) b
- (47 μM) b
- (24 μM) b
- (22 μM) b
-
20-72c
8c
?
?
?
Rutin
0.3-1.6
1.2±2.1
266
6.43
C27H30O16
610.52
?
?
?
?
?
?
?
?
?
?
Phenolic acids (~0.1%)
Caffeic acid
0.1
1.4±0.4
77.8
3.64
C9H8O4
180.16
?
?
?
-
?
?
?
?
?
?
Chlorogenic acid
<0.1%
-0.36±0.43
165
3.33
C16H18O9
354.31
0
0
0
0
?
?
?
?
?
?
Acronyms and symbols
Acronym/Symbol
Meaning
MW
Molecular weight in g•mol−1.
PGP
P-glycoprotein
t1/2
Elimination half-life in hours
Tmax
Time to peak plasma concentration in hours
Cmax
Peak plasma concentration in mM
CSS
Steady state plasma concentration in mM
Partition coefficient.
PSA
Polar surface area of the molecule in question in square angstroms (Å2). Obtained from PubChem (the access date is 13 December 2013).
Conc.
These values pertain to the approximation concentration (in %) of the constituents in the fresh plant material
-
Indicates inhibition of the enzyme in question.
+
Indicates an inductive effect on the enzyme in question.
0
No effect on the enzyme in question.
5-HT
5-hydroxytryptamine — synonym for serotonin.
DA
Dopamine
NE
Norepinephrine
GABA
γ-aminobutyric acid
Glu
Glutamate
Gly
Glycine
Ch
Choline
a
?
b
?
c
?
Notes:
^In brackets is the IC50/EC50 value depending on whether it is an inhibitory or inductive action being exhibited, respectively.
^As with last note
^As with last note
^As with last note
^As with last note
^Values given in brackets are IC50/EC50 depending on whether it's an inhibitory or inductive action the compound displays towards the biologic target in question. If it pertains to bacterial growth inhibition the value is MIC50
Livestock
Poisoning
In large doses, St John's wort is poisonous to grazing livestock (cattle, sheep, goats, horses).[18] Behavioural signs of poisoning are general restlessness and skin irritation. Restlessness is often indicated by pawing of the ground, headshaking, head rubbing, and occasional hindlimb weakness with knuckling over, panting, confusion, and depression. Mania and hyperactivity may also result, including running in circles until exhausted. Observations of thick wort infestations by Australian graziers include the appearance of circular patches giving hillsides a 'crop circle' appearance, it is presumed, from this phenomenon. Animals typically seek shade and have reduced appetite. Hypersensitivity to water has been noted, and convulsions may occur following a knock to the head. Although general aversion to water is noted, some may seek water for relief.
Severe skin irritation is physically apparent, with reddening of non-pigmented and unprotected areas. This subsequently leads to itch and rubbing, followed by further inflammation, exudation, and scab formation. Lesions and inflammation that occur are said to resemble the conditions seen in foot and mouth disease. Sheep have been observed to have face swelling, dermatitis, and wool falling off due to rubbing. Lactating animals may cease or have reduced milk production; pregnant animals may abort. Lesions on udders are often apparent. Horses may show signs of anorexia, depression (with a comatose state), dilated pupils, and injected conjunctiva.
Diagnosis
Increased respiration and heart rate is typically observed while one of the early signs of St John's wort poisoning is an abnormal increase in body temperature. Affected animals will lose weight, or fail to gain weight; young animals are more affected than old animals. In severe cases death may occur, as a direct result of starvation, or because of secondary disease or septicaemia of lesions. Some affected animals may accidentally drown. Poor performance of suckling lambs (pigmented and non-pigmented) has been noted, suggesting a reduction in the milk production, or the transmission of a toxin in the milk.
Photosensitisation
Most clinical signs in animals are caused by photosensitisation.[43] Plants may induce either primary or secondary photosensitisation:
primary photosensitisation directly from chemicals contained in ingested plants
secondary photosensitisation from plant-associated damage to the liver.
Araya and Ford (1981) explored changes in liver function and concluded there was no evidence of Hypericum-related effect on the excretory capacity of the liver, or any interference was minimal and temporary. However, evidence of liver damage in blood plasma has been found at high and long rates of dosage.
Photosensitisation causes skin inflammation by a mechanism involving a pigment or photodynamic compound, which when activated by a certain wavelength of light leads to oxidation reactions in vivo. This leads to tissue lesions, particularly noticeable on and around parts of skin exposed to light. Lightly covered or poorly pigmented areas are most conspicuous. Removal of affected animals from sunlight results in reduced symptoms of poisoning.
Chemistry
Detection in body fluids
Hypericin, pseudohypericin, and hyperforin may be quantitated in plasma as confirmation of usage and to estimate the dosage. These three active substituents have plasma elimination half-lives within a range of 15–60 hours in humans. None of the three has been detected in urine specimens.[44]
The naphthodianthrones hypericin and pseudohypericin along with the phloroglucinol derivative hyperforin are thought to be among the numerous active constituents.[2][45][46][47] It also contains essential oils composed mainly of sesquiterpenes.[2]
Selected chemical constituents of Hypericum perforatum
Hypericin
Pseudohypericin
Adhyperforin
Hyperforin
Amentoflavone
Hyperoside
Rutin
Kaempferol
Myricetin
Quercetin
Quercitrin
Isoquercitrin
Luteolin
Catechin
Epicatechin
Epigallocatechin
Chlorogenic acid
Caffeic acid
Kielcorin
Norathyriol
Research
Antidepressant
Further information: Hyperforin
Some studies have supported the efficacy of St John's wort as a treatment for depression in humans, but have not concluded it as a replacement for more studied treatments, and proper medical consultation.[21] A 2015 meta-analysis review concluded that it has superior efficacy to placebo in treating depression, is as effective as standard antidepressant pharmaceuticals for treating depression, and has fewer adverse effects than other antidepressants.[48] The authors concluded that it is difficult to assign a place for St. John's wort in the treatment of depression owing to limitations in the available evidence base, including large variations in efficacy seen in trials performed in German-speaking relative to other countries. In Germany, St. John's wort may be prescribed for mild to moderate depression, especially in children and adolescents.[49] A 2008 Cochrane review of 29 clinical trials concluded that it was superior to placebo in patients with major depression, as effective as standard antidepressants and had fewer side-effects.[50]
In the United States, St John's wort is considered a dietary supplement by the FDA, and is not regulated by the same standards as a prescription drug.[51][52] According to the United States National Center for Complementary and Integrative Health, "St. John’s wort isn’t consistently effective for depression."[21] Supplement strength varies by manufacturer and possibly by batch.[53] A 2016 review noted that use of St. John's wort for mild and moderate depression was better than placebo for improving depression symptoms, and comparable to antidepressant medication.[54]
Other
A major constituent chemical, hyperforin, may be useful for treatment of alcoholism, although dosage, safety and efficacy have not been studied.[55][56] Hyperforin has also displayed antibacterial properties against Gram-positive bacteria, although dosage, safety and efficacy have not been studied.[57] Herbal medicine has also employed lipophilic extracts from St John's wort as a topical remedy for wounds, abrasions, burns, and muscle pain.[56] The positive effects that have been observed are generally attributed to hyperforin due to its possible antibacterial and anti-inflammatory effects.[56] For this reason hyperforin may be useful in the treatment of infected wounds and inflammatory skin diseases.[56] In response to hyperforin's incorporation into a new bath oil, a study to assess potential skin irritation was conducted which found good skin tolerance of St John's wort.[56]
See also
Dietary supplement
EU Food supplements directive
List of plants poisonous to equines
St John's-bread
Notes
^Less common names and synonyms include Tipton's weed, rosin rose, goatweed, chase-devil, or Klamath weed.[2]
References
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^Gaid, M.; Biedermann, E.; Füller, J.; Haas, P.; Behrends, S.; Krull, R.; Scholl, S.; Wittstock, U.; Müller-Goymann, C.; Beerhues, L. Biotechnological Production of Hyperforin for Pharmaceutical Formulation. Eur. J. Pharm. Biopharm. 2018, 126, 10–26. https://doi.org/10.1016/j.ejpb.2017.03.024.
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^"Enzymes". Hyperforin. Human Metabolome Database. 3.6. University of Alberta. 30 June 2013.
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^Süntar, Ipek Peşin; Akkol, Esra Küpeli; Yılmazer, Demet; Baykal, Turhan; Kırmızıbekmez, Hasan; Alper, Murat; Yeşilada, Erdem (2010). "Investigations on the in vivo wound healing potential of Hypericum perforatum L". Journal of Ethnopharmacology. 127 (2): 468–77. doi:10.1016/j.jep.2009.10.011. PMID 19833187.
^Schempp, Christoph M; Pelz, Klaus; Wittmer, Annette; Schöpf, Erwin; Simon, Jan C (1999). "Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria". The Lancet. 353 (9170): 2129. doi:10.1016/S0140-6736(99)00214-7. PMID 10382704.
^ abErnst E, Rand JI, Barnes J, Stevinson C (1998). "Adverse effects profile of the herbal antidepressant St. John's wort (Hypericum perforatum L.)". Eur. J. Clin. Pharmacol. 54 (8): 589–94. doi:10.1007/s002280050519. PMID 9860144.
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^Parker V, Wong AH, Boon HS, Seeman MV (2001). "Adverse reactions to St John's Wort". Can J Psychiatry. 46 (1): 77–9. doi:10.1177/070674370104600112. PMID 11221494.
^Greeson, JM; Sanford, B; Monti, DA (February 2001). "St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature". Psychopharmacology. 153 (4): 402–14. doi:10.1007/s002130000625. PMID 11243487.
^ abHoban, Claire L.; Byard, Roger W.; Musgrave, Ian F. (July 2015). "A comparison of patterns of spontaneous adverse drug reaction reporting with St. John's Wort and fluoxetine during the period 2000-2013". Clinical and Experimental Pharmacology and Physiology. 42 (7): 747–51. doi:10.1111/1440-1681.12424. PMID 25988866. The organ systems affected by ADRs to St John's Wort and fluoxetine have a similar profile, with the majority of cases affecting the central nervous system (45.2%, 61.7%).
^Borrelli, F; Izzo, AA (December 2009). "Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations". The AAPS Journal. 11 (4): 710–27. doi:10.1208/s12248-009-9146-8. PMC 2782080. PMID 19859815.
^"Renolazine". MedlinePlus, US National Library of Medicine. 15 January 2016. Retrieved 21 June 2017.
^Wenk M, Todesco L, Krähenbühl S (2004). "Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females". Br J Clin Pharmacol. 57 (4): 495–499. doi:10.1111/j.1365-2125.2003.02049.x. PMC 1884478. PMID 15025748.
^Kober M, Pohl K, Efferth T (2008). "Molecular mechanisms underlying St. John's wort drug interactions". Curr. Drug Metab. 9 (10): 1027–37. doi:10.2174/138920008786927767. PMID 19075619.
^Gurley BJ, Swain A, Williams DK, Barone G, Battu SK (2008). "Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics". Mol Nutr Food Res. 52 (7): 772–9. doi:10.1002/mnfr.200700081. PMC 2562898. PMID 18214850.
^ abGreeson JM, Sanford B, Monti DA (February 2001). "St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature" (PDF). Psychopharmacology. 153 (4): 402–414. doi:10.1007/s002130000625. PMID 11243487. Archived from the original (PDF) on 11 June 2014.
^ abcdeAnzenbacher, Pavel; Zanger, Ulrich M., eds. (2012). Metabolism of Drugs and Other Xenobiotics. Weinheim, Germany: Wiley-VCH. doi:10.1002/9783527630905. ISBN 978-3-527-63090-5.
^St John's wort effects on animals Archived 26 February 2015 at the Wayback Machine
^R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. 1445–1446.
^Umek A, Kreft S, Kartnig T, Heydel B (1999). "Quantitative phytochemical analyses of six hypericum species growing in slovenia". Planta Med. 65 (4): 388–90. doi:10.1055/s-2006-960798. PMID 17260265.
^Tatsis EC, Boeren S, Exarchou V, Troganis AN, Vervoort J, Gerothanassis IP (2007). "Identification of the major constituents of Hypericum perforatum by LC/SPE/NMR and/or LC/MS". Phytochemistry. 68 (3): 383–93. doi:10.1016/j.phytochem.2006.11.026. PMID 17196625.
^Schwob I, Bessière JM, Viano J.Composition of the essential oils of Hypericum perforatum L. from southeastern France.C R Biol. 2002;325:781-5.
^Linde K, Kriston L, Rücker G, Jamila S, Schumann I, Meissner K, Sigterman K, Schneider A (February 2015). "Efficacy and acceptability of pharmacological treatments for depressive disorders in primary care: systematic review and network meta-analysis". Annals of Family Medicine. 13 (1): 69–79. doi:10.1370/afm.1687. PMC 4291268. PMID 25583895.
^Dörks, M; Langner, I; Dittmann, U; Timmer, A; Garbe, E (August 2013). "Antidepressant drug use and off-label prescribing in children and adolescents in Germany: results from a large population-based cohort study". European Child & Adolescent Psychiatry. 22 (8): 511–8. doi:10.1007/s00787-013-0395-9. PMID 23455627.
^Linde K, Berner MM, Kriston L (2008). Linde K (ed.). "St John's wort for major depression". Cochrane Database Syst Rev (4): CD000448. doi:10.1002/14651858.CD000448.pub3. PMID 18843608.
^"Information for Consumers - Dietary Supplements: What You Need to Know". FDA.gov. May 2017. Retrieved 8 October 2018.
^O'Connor, Anahad (19 January 2016). "'Supplements and Safety' Explores What's in Your Supplements". The New York Times. Retrieved 8 October 2018.
^"Questions and Answers on Current Good Manufacturing Practices—Production and Process Controls". www.fda.gov. Retrieved 8 October 2018. Do CGMPs require [...] successful process validation batches [...]? No. Neither the CGMP regulations nor FDA policy specifies a minimum number of batches to validate a manufacturing process.
^Apaydin EA, Maher AR, Shanman R, Booth MS, Miles JN, Sorbero ME, Hempel S (2016). "A systematic review of St. John's wort for major depressive disorder". Syst Rev. 5 (1): 148. doi:10.1186/s13643-016-0325-2. PMC 5010734. PMID 27589952.
^Kumar V, Mdzinarishvili A, Kiewert C, Abbruscato T, Bickel U, van der Schyf CJ, Klein J (2006). "NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's Wort" (PDF). J. Pharmacol. Sci. 102 (1): 47–54. doi:10.1254/jphs.FP0060378. PMID 16936454.
^ abcdeReuter J, Huyke C, Scheuvens H, Ploch M, Neumann K, Jakob T, Schempp CM (2008). "Skin tolerance of a new bath oil containing St. John's wort extract". Skin Pharmacol Physiol. 21 (6): 306–311. doi:10.1159/000148223. PMID 18667843.
^Cecchini C, Cresci A, Coman MM, Ricciutelli M, Sagratini G, Vittori S, Lucarini D, Maggi F (2007). "Antimicrobial activity of seven hypericum entities from central Italy". Planta Med. 73 (6): 564–6. doi:10.1055/s-2007-967198. PMID 17516331.
External links
Wikispecies has information related to Hypericum perforatum
Wikimedia Commons has media related to Hypericum perforatum.
Invasive Species Profile — St. Johnswort (Hypericum perforatum), National Invasive Species Information Center, United States National Agricultural Library
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Hypericum species by section
List of Hypericum species
clade Euhypericum
Adenosepalum
H. annulatum
H. athoum
H. atomarium
H. cuisinii
H. delphicum
H. lanuginosum
H. montanum
H. reflexum
H. abilianum
H. aethiopicum
H. afrum
H. conjungens
H. glandulosum
H. kiboënse
H. caprifolium
H. coadunatum
H. collenettiae
H. naudinianum
H. psilophytum
H. pubescens
H. scruglii
H. sinaicum
H. somaliense
H. tomentosum
H. decaisneanum
H. formosissimum
H. huber-morathii
H. minutum
H. sechmenii
Bupleuroides
H. bupleuroides
Campylopus
H. cerastioides
Concinna
H. concinnum
Coridium
H. amblycalyx
H. asperuloides
H. coris
H. empetrifolium
H. ericoides
H. jovis
Crossophyllum
H. adenotrichum
H. aucheri
H. orientale
H. thasium
Drosocarpium
H. ambiguum
H. barbatum
H. bithynicum
H. confusum
H. montbretii
H. perfoliatum
H. richeri
H. rochelii
H. rumeliacum
H. spruneri
H. trichocaulon
H. umbellatum
H. vesiculosum
H. × reinosae
Elodeoida
H. austroyunnanicum
H. elodeoides
H. hubeiense
H. kingdonii
H. petiolulatum
H. qinlingense
H. seniawinii
Graveolentia
H. collinum
H. epigeium
H. formosum
H. graveolens
H. macvaughii
H. oaxacanum
H. pringlei
H. pseudomaculatum
H. punctatum
H. × mitchellianum
Hirtella
H. amblysepalum
H. asperulum
H. capitatum
H. hedgei
H. helianthemoides
H. hirtellum
H. libanoticum
H. lysimachioides
H. olivieri
H. pseudolaeve
H. retusum
H. scabroides
H. scabrum
H. spectabile
H. thymbrifolium
H. thymopsis
H. vermiculare
H. apiculatum
H. apricum
H. callithyrsum
H. davisii
H. elongatum
H. hyssopifolium
H. karjaginii
H. microcalycinum
H. salsolifolium
H. sorgerae
H. tymphresteum
Humifusoideum
H. beccarii
H. nagasawae
H. natalense
H. nokoense
H. peplidifolium
H. wilmsii
Hypericum
H. asahinae
H. elegans
H. erectum
H. furusei
H. gracillimum
H. hakonense
H. kawaranum
H. kinashianum
H. kitamense
H. kiusianum
H. kurodakeanum
H. nikkoense
H. nuporoense
H. ovalifolium
H. pseudoerectum
H. pseudopetiolatum
H. taihezanense
H. uniglandulosum
H. vulcanicum
H. watanabei
H. yamamotoanum
H. yamamotoi
H. attenuatum
H. iwate-littorale
H. maculatum
H. momoseanum
H. perforatum
H. scouleri
H. tetrapterum
H. triquetrifolium
H. undulatum
H. enshiense
H. faberi
H. kamtschaticum
H. nakaii
H. oliganthum
H. pibairense
H. senanense
H. sikokumontanum
Monanthema
H. daliense
H. himalaicum
H. ludlowii
H. monanthemum
H. subcordatum
H. trigonum
H. wightianum
Oligostema
H. andjerinum
H. australe
H. humifusum
H. kelleri
H. linariifolium
H. × caesariense
Origanifolia
H. albiflorum
H. aviculariifolium
H. bourgaei
H. cymbiferum
H. ichelense
H. imbricatum
H. laxiflorum
H. leprosum
H. origanifolium
H. papillare
H. salsugineum
H. trachyphyllum
H. uniflorum
Sampsonia
H. assamicum
H. sampsonii
Taeniocarpium
H. armenum
H. crenulatum
H. fissurale
H. havvae
H. hirsutum
H. kotschyanum
H. linarioides
H. malatyanum
H. marginatum
H. neurocalycinum
H. nummularioides
H. nummularium
H. peshmenii
H. pruinatum
H. pseudorepens
H. pulchrum
H. pumilio
H. saxifragum
H. taygeteum
H. theodori
H. thymifolium
H. vaccinioides
H. venustum
clade Brathys s.l.
Brathys
H. aciculare
H. andinum
H. baccharoides
H. bolivaricum
H. bryoides
H. caracasanum
H. cardonae
H. cassiopiforme
H. costaricense
H. decandrum
H. harlingii
H. horizontale
H. jaramilloi
H. juniperinum
H. lancioides
H. llanganaticum
H. magdalenicum
H. magniflorum
H. marahuacanum
H. mexicanum
H. millefolium
H. parallelum
H. pimeleoides
H. prietoi
H. prostratum
H. pseudobrathys
H. pycnophyllum
H. recurvum
H. ruscoides
H. selaginella
H. sprucei
H. strictum
H. struthiolifolium
H. stuebelii
H. tetrastichum
H. valleanum
H. wurdackii
H. acostanum
H. asplundii
H. callacallanum
H. carinosum
H. castellanoi
H. cuatrecasii
H. espinalii
H. garciae
H. gladiatum
H. goyanesii
H. hartwegii
H. humboldtianum
H. irazuense
H. lancifolium
H. laricifolium
H. loxense
H. lycopodioides
H. maguirei
H. martense
H. matangense
H. myricariifolium
H. papillosum
H. paramitanum
H. phellos
H. piriai
H. quitense
H. radicans
H. roraimense
H. sabiniforme
H. simonsii
H. stenopetalum
H. thuyoides
H. woodianum
H. arbuscula
H. beamanii
H. chamaemyrtus
H. cymobrathys
H. dichotomum
H. diosmoides
H. drummondii
H. eastwoodianum
H. fuertesii
H. galinum
H. gentianoides
H. gnidioides
H. peninsulare
H. rubritinctum
H. styphelioides
H. terrae-firmae
Trigynobrathys
H. brasiliense
H. caespitosum
H. campestre
H. caprifoliatum
H. carinatum
H. cavernicola
H. connatum
H. cordatum
H. cumulicola
H. gramineum
H. harperi
H. legrandii
H. linoides
H. lorentzianum
H. majus
H. microlicioides
H. myrianthum
H. polyanthemum
H. rigidum
H. salvadorense
H. setosum
H. silenoides
H. teretiusculum
H. ternum
H. virgatum
H. anagalloides
H. aphyllum
H. arenarioides
H. boreale
H. brevistylum
H. canadense
H. globuliferum
H. gymnanthum
H. humbertii
H. japonicum
H. killipii
H. lalandii
H. monadenum
H. moranense
H. mutilum
H. oligandrum
H. parvulum
H. pauciflorum
H. paucifolium
H. pedersenii
H. philonotis
H. pleiostylum
H. pratense
H. pumilum
H. relictum
H. scioanum
H. thesiifolium
H. × dissimulatum
clade Myriandra-Ascyreia s.l.
Androsaemum
H. androsaemum
H. foliosum
H. grandifolium
H. hircinum
H. × inodorum
Ascyreia
H. acmosepalum
H. addingtonii
H. augustinii
H. beanii
H. bellum
H. calycinum
H. choisianum
H. cohaerens
H. cordifolium
H. curvisepalum
H. elatoides
H. forrestii
H. gaitii
H. gracilipes
H. griffithii
H. henryi
H. hookerianum
H. kouytchense
H. lacei
H. lagarocladum
H. lancasteri
H. leschenaultii
H. lobbii
H. maclarenii
H. monogynum
H. mysurense
H. mysurense
H. oblongifolium
H. pachyphyllum
H. patulum
H. podocarpoides
H. prattii
H. pseudohenryi
H. reptans
H. sherriffii
H. siamense
H. stellatum
H. subsessile
H. tenuicaule
H. uralum
H. wardianum
H. williamsii
H. wilsonii
Camplyosporus
H. balfourii
H. bequaertii
H. cerastioides
H. gnidiifolium
H. lanceolatum
H. madagascariense
H. quartinianum
H. revolutum
H. roeperianum
H. socotranum
H. synstylum
Myriandra
H. crux-andreae
H. edisonianum
H. hypericoides
H. suffruticosum
H. tetrapetalum
H. dolabriforme
H. myrtifolium
H. brachyphyllum
H. chamaenerium
H. chapmanii
H. densiflorum
H. exile
H. fasciculatum
H. frondosum
H. galioides
H. glomeratum
H. kalmianum
H. lissophloeus
H. lloydii
H. lobocarpum
H. longistylum
H. lydium
H. nitidum
H. opacum
H. prolificum
H. swinkianum
H. tenuifolium
H. buckleyi
H. adpressum
H. apocynifolium
H. cistifolium
H. ellipticum
H. microsepalum
H. nudiflorum
H. sphaerocarpum
Psorophytum
H. balearicum
Roscyna
H. ascyron
H. przewalskii
Takasagoya
H. formosanum
H. geminiflorum
H. nakamurai
H. senkakuinsulare
H. subalatum
Mediterranean Grade
Adenotrias
H. aciferum
H. aegypticum
H. russeggeri
Arthrophyllum
H. cardiophyllum
H. nanum
H. pamphylicum
H. rupestre
H. vacciniifolium
Heterophylla
H. heterophyllum
Inodora
H. xylosteifolium
Olympia
H. auriculatum
H. lycium
H. olympicum
H. polyphyllum
Santomasia
H. steyermarkii
Triadenoides
H. fieriense
H. haplophylloides
H. musadoganii
H. pallens
H. scopulorum
H. ternatum
H. tortuosum
Tripentas
H. elodes
Umbraculoides
H. umbraculoides
Webbia
H. canariense
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Dietary supplements
Types
Amino acids
Bodybuilding supplement
Energy drink
Energy bar
Fatty acids
Herbal supplements
Minerals
Prebiotics
Probiotics (Lactobacillus
Bifidobacterium)
Protein bar
Vitamins
Vitamins and chemical elements ("minerals")
Retinol (Vitamin A)
B vitamins: Thiamine (B1)
Riboflavin (B2)
Niacin (B3)
Pantothenic acid (B5)
Pyridoxine (B6)
Biotin (B7)
Folic acid (B9)
Cyanocobalamin (B12)
Ascorbic acid (Vitamin C)
Ergocalciferol and Cholecalciferol (Vitamin D)
Tocopherol (Vitamin E)
Naphthoquinone (Vitamin K)
Calcium
Choline
Chromium
Cobalt
Copper
Fluorine
Iodine
Iron
Magnesium
Manganese
Molybdenum
Phosphorus
Potassium
Selenium
Sodium
Sulfur
Zinc
Other common ingredients
AAKG
β-hydroxy β-methylbutyrate
Carnitine
Chondroitin sulfate
Cod liver oil
Copper gluconate
Creatine
Dietary fiber
Echinacea
Elemental calcium
Ephedra
Fish oil
Folic acid
Ginseng
Glucosamine
Glutamine
Grape seed extract
Guarana
Iron supplements
Japanese Honeysuckle
Krill oil
Lingzhi
Linseed oil
Lipoic acid
Milk thistle
Melatonin
Red yeast rice
Royal jelly
Saw palmetto
Spirulina
St John's wort
Taurine
Wheatgrass
Wolfberry
Yohimbine
Zinc gluconate
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English Journal
Bioactive compounds from Hypericum humifusum and Hypericum perfoliatum: inhibition potential of polyphenols with acetylcholinesterase and key enzymes linked to type-2 diabetes.
Béjaoui A1, Ben Salem I2, Rokbeni N3, M'rabet Y3, Boussaid M1, Boulila A3.
ST. JOHN'S WORT (Hypericum perforatum) This plant grows in meadows, hedges, woodlands and on roadsides. It reaches a height of 60 cm., is much branched and its golden-yellow flowers, grouped in umbels, are easily ...
Hypericum Perforatum Hypericum's complete botanical name is Hypericum perforatum. Perforatum is Latin for "perforated." The leaves of Hypericum perforatum, when held to the light, reveal translucent dots, giving the impression that ...