English Journal

Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery.

Makhlof A, Tozuka Y, Takeuchi H.SourceLaboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan; Department of Industrial Pharmacy, Assiut University, Assiut, Egypt.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.2011 Apr 18;42(5):445-51. Epub 2010 Dec 21.
Chitosan nanoparticles (CS NPs) have been commonly regarded as potential carriers for the mucosal delivery of therapeutic peptides because of their biocompatibility, bioadhesion and permeation enhancing properties. However, they have limited colloidal stability and readily dissociate and dissolve in
PMID 21182939

Differences in crystallization rate of nitrendipine enantiomers in amorphous solid dispersions with HPMC and HPMCP.

Miyazaki T, Aso Y, Yoshioka S, Kawanishi T.SourceDivision of Drugs, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. miyazaki@nihs.go.jp
International journal of pharmaceutics.2011 Apr 4;407(1-2):111-8. Epub 2011 Jan 26.
To clarify the contribution of drug-polymer interaction to the physical stability of amorphous solid dispersions, we studied the crystallization rates of nitrendipine (NTR) enantiomers with identical physicochemical properties in the presence of hydroxypropylmethylcellulose (HPMC), hydroxypropylmeth
PMID 21277962

Japanese Journal

Enteric Microsphere Formulations of Papain for Oral Delivery

SHARMA Manu,SHARMA Vinay,PANDA Amulya K.,MAJUMDAR Dipak K.
YAKUGAKU ZASSHI 131(5), 697-709, 2011
… Enteric microspheres formulations of papain were prepared by w/o/w emulsion solvent evaporation using hydroxypropyl methylcellulose phthalate (HPMCP), Eudragit L 100 and Eudragit S 100, to avoid gastric inactivation of papain. … HPMCP and Eudragit L 100 microspheres facilitated almost complete release of papain within an hour at pH 6.0 and 6.8, respectively while Eudragit S 100 microspheres released 84.56% papain at pH 7.4, following Higuchi kinetics. …
NAID 130000678852

Statistical Optimization of Tamsulosin Hydrochloride Controlled Release Pellets Coated with the Blend of HPMCP and HPMC

KIM Jeong-Soo,KIM Min-Soo,PARK Hee Jun,LEE Sibeum,PARK Jeong-Sook,HWANG Sung-Joo
Chemical & pharmaceutical bulletin 55(6), 936-939, 2007-06-01
… The objective of the present study was to evaluate three coating parameters for the application of a blend of HPMCP and HPMC in ethylcellulose aqueous dispersions (Surelease[○!R]) in order to obtain controlled release of tamsulosin hydrochloride. … The selected independent variables, HPMCP content (X_1), HPMC content (X_2) and coating level (X_3), were optimized with a three-factor, three-level Box-Behnken design. …
NAID 110006278703

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