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1. アミロイド疾患の遺伝的要因genetic factors in the amyloid diseases [show details]
…(TGFB1), or BIGH3 on chromosome 5 in lattice corneal dystrophy type 1, granular corneal dystrophies (GCD) type 1 (characterized by amorphous aggregates), GCD type 2 (characterized by a combination of amyloid …
2. Hereditary palmoplantar keratodermashereditary palmoplantar keratodermas [show details]
… prevalence of epidermolytic PPK (PPK Vorner type), the most common type of PPK, was 4.4 per 100,000 . In Japan and China, the estimated prevalence of PPK type Nagashima, the most common PPK in Asia, is …
3. レーザー屈折矯正手術laser refractive surgery [show details]
…entering the eye do not focus properly on the retina: In myopia (nearsightedness), the most common type of refractive error, the cornea is too curved or the lens is too powerful for the length of the globe …
4. 角膜剥離および角膜異物：臨床症状および診断corneal abrasions and corneal foreign bodies clinical manifestations and diagnosis [show details]
…applicators, hand tools, branches, and leaves, or by a foreign body that has lodged under the lid. Special types of traumatic abrasions include the following: Foreign body – Foreign body related abrasions are defects …
5. 振子様眼振pendular nystagmus [show details]
…Diagnosis is an exercise in pattern recognition since pendular nystagmus is subdivided into a number of types, some characterized by specific trajectories: Acquired pendular nystagmus; Pendular nystagmus from …

English Journal

Lithium chloride (LiCl) induced autophagy and downregulated expression of transforming growth factor β-induced protein (TGFBI) in granular corneal dystrophy.

Nie D, Peng Y, Li M, Liu X, Zhu M, Ye L.
Experimental eye research. 2018 08;173()44-50.
This study evaluated whether lithium chloride (LiCl) prevents cytoplasmic accumulation of mutant-transforming growth factor β-induced protein (Mut-TGFBI) in granular corneal dystrophy (GCD) via activation of the autophagy pathway. Levels of TGFBI and microtubule-associated protein 1A/1B-light chain
PMID 29679546

Persistence of granular corneal dystrophy type-1 deposits in the predescemetic layer after big-bubble deep anterior lamellar keratoplasty.

Müller EG, Gomes JÁP, Nosé W, Nosé RM.
Arquivos brasileiros de oftalmologia. ;81(1)66-69.
We report intraoperative finding of Granular Corneal Dystrophy Type-1 (GCD1) deposits after stromal pneumodissection in deep anterior lamellar keratoplasty (DALK) in a 61-year-old female. Pneumodissection was performed from the center to the periphery of the cornea, characterizing a big bubble type
PMID 29538598

Recurrence of Granular Corneal Dystrophy Type 1 After Phototherapeutic Keratectomy, Lamellar Keratoplasty, and Penetrating Keratoplasty in a Single Population.

Lewis DR, Price MO, Feng MT, Price FW.
Cornea. 2017 Oct;36(10)1227-1232.
To describe the recurrence of granular corneal dystrophy type 1 (GCD1) after penetrating keratoplasty (PKP), anterior lamellar keratoplasty (ALK), deep anterior lamellar keratoplasty (DALK), and phototherapeutic keratectomy (PTK) in a single population. The time required to achieve best-corrected vi
PMID 28749898

Japanese Journal

Inter-familial variability and intra-familial similarities of granular corneal dystrophy Groenouw type I with respect to biomicroscopic appearance and symptomatology