アンチモン酸メグルミン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/27 06:13:17」(JST)
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Meglumine antimoniate
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Systematic (IUPAC) name |
Hydroxy-dioxostiborane; (2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentol |
Clinical data |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
Identifiers |
CAS Registry Number
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133-51-7 N |
ATC code
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P01CB01 QP51AB01 |
PubChem |
CID 64953 |
ChemSpider |
58479 Y |
ChEMBL |
CHEMBL239129 Y |
NIAID ChemDB |
008733 |
Chemical data |
Formula |
Variable |
Molecular mass
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Variable |
SMILES
- O=[Sb](=O)O.O[C@@H]([C@@H](O)[C@H](O)[C@@H](O)CNC)CO
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InChI
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InChI=1S/C7H17NO5.H2O.2O.Sb/c1-8-2-4(10)6(12)7(13)5(11)3-9;;;;/h4-13H,2-3H2,1H3;1H2;;;/q;;;;+1/p-1/t4-,5+,6+,7+;;;;/m0..../s1 Y
Key:XOGYVDXPYVPAAQ-SESJOKTNSA-M Y
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N (what is this?) (verify) |
Meglumine antimoniate (or meglumine antimonate) is a medicine used for treating leishmaniasis.[1] It is manufactured by Aventis[2] and sold as Glucantime in France, and Glucantim in Italy. It belongs to a group of compounds known as the pentavalent antimonials. It is administered by intramuscular injection.
See also
References
- ^ Soto, J.; Fuya, P.; Herrera, R.; Berman, J. (1998). "Topical paromomycin/methylbenzethonium chloride plus parenteral meglumine antimonate as treatment for American cutaneous leishmaniasis: Controlled study". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 26 (1): 56–58. doi:10.1086/516267. PMID 9455509. edit
- ^ Aventis press release, 15 April 2005. (German)
Antiparasitics – antiprotozoal agents – Excavata antiparasitics (P01)
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Discicristata |
Trypanosomiasis
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- African trypanosomiasis: ornithine (Eflornithine#)
- arsenical (Melarsoprol#)
- benzamidine (Pentamidine#)
- naphthalenesulfonate (Suramin#)
Chagas disease: nitroimidazole (Benznidazole#)
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Leishmaniasis
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- macrolide (Amphotericin B#)
Pentavalent antimonials (Meglumine antimoniate#, Sodium stibogluconate)
- benzamidine (Pentamidine#)
- phosphorylcholine (Miltefosine)
- neomycin (Paromomycin)
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PAM
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- macrolide (Amphotericin B)
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Trichozoa |
Giardiasis
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- nitroimidazole (Metronidazole#, Tinidazole)
- benzimidazole (Albendazole)
- thiazole (Nitazoxanide)
- nitrofuran (Furazolidone)
- aminoacridine (Quinacrine)
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Trichomoniasis
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- nitroimidazole (Carnidazole, Metronidazole#, Tinidazole)
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Dientamoebiasis
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- nitroimidazole (Metronidazole
- Secnidazole)
- oxyquinoline (Iodoquinol)
- tetracycline (Doxycycline)
- neomycin (Paromomycin)
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of protozoan infection
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Description |
- Alveolata
- Amoebozoa
- Excavata
- Protist
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Disease |
- Amoebozoa
- Chromalveolate
- Excavata
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Treatment |
- Drugs
- amoeboa
- chromalveolate
- excavata
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UpToDate Contents
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English Journal
- In vitro leishmanicidal activity of 1,3-disubstituted 5-nitroindazoles.
- Marín C1, Ramírez-Macías I1, Rosales MJ1, Muro B2, Reviriego F2, Navarro P2, Arán VJ3, Sánchez-Moreno M4.
- Acta tropica.Acta Trop.2015 Aug;148:170-8. doi: 10.1016/j.actatropica.2015.04.028. Epub 2015 May 5.
- The antiprotozoal activity of some indazole-derived amines (2, 3, 5-8) as well as that of some simple structurally related 3-alkoxy-1-alkyl-5-nitroindazoles (1, 4) against promastigote and amastigote forms of Leishmania infantum and Leishmania braziliensis is reported. In some cases, these compounds
- PMID 25956673
- Acid heteropolysaccharides with potent antileishmanial effects.
- Kangussu-Marcolino MM1, do Rosário MM1, Noseda MD1, Duarte ME1, Ducatti DR1, Cassolato JE1, Iacomini M2, Martinez GR1, Rocha ME1, Cadena SM1, Noleto GR1.
- International journal of biological macromolecules.Int J Biol Macromol.2015 Jul 7. pii: S0141-8130(15)00467-5. doi: 10.1016/j.ijbiomac.2015.07.006. [Epub ahead of print]
- The present study investigated in vitro the effects of sulphated heterorhamnan (Go3), iota-/nu-carrageenans (G3d and EHW-I) and arabinogalactan (ARAGAL) polysaccharides on macrophage activation and inhibition of intracellular amastigotes of Leishmania (L.) amazonensis. All the sulphated polysacchari
- PMID 26162246
- A comparative study between the efficacy of oral cimetidine and low-dose systemic meglumine antimoniate (MA) with a standard dose of systemic MA in the treatment of cutaneous leishmaniasis.
- Shanehsaz SM1, Ishkhanian S1.
- International journal of dermatology.Int J Dermatol.2015 Jul;54(7):834-8. doi: 10.1111/ijd.12709.
- Cutaneous leishmaniasis (CL) is a major world health problem, which is increasing in incidence. Pentavalent antimonials have been considered as standard treatment for leishmaniasis. Many studies are performed to find an effective and safe treatment for patients with CL. The aim of this study was to
- PMID 26108265
Japanese Journal
- PCR Follow-up Examination After Treatment of Canine Leishmaniosis (CaL)
- Tokai journal of experimental and clinical medicine 23(6), 285-292, 1998-08-29
- NAID 110004700223
- Clinical follow-up examination after treatment of canine leishmaniasis
- Tokai journal of experimental and clinical medicine 23(6), 279-283, 1998-08-29
- NAID 110004700222
- Meglumine Antimonateの局注が奏効したCutaneous Leishmaniasis
Related Links
- Glucantime Drug Information from Drugs.com. Includes Glucantime side effects, interactions and indications. ... Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter ...
- Detailed drug Information for Glucantime. Includes common brand names, drug descriptions, warnings, side effects and dosing information. ... Drugs.com provides accurate and independent information on more than 24,000 ...
Related Pictures
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