Containment in industrial biotechnology within wastewater treatment plants.
Noordover JA1, Hofmeester JJ, van der Burg JP, de Leeuw A, van Dijck PW, Luiten RG, Groot GS.
Journal of industrial microbiology & biotechnology.J Ind Microbiol Biotechnol.2002 Feb;28(2):65-9.
Both physical and biological containment are considered to be essential parts in the risk analysis of industrial Good Industrial Large-Scale Practice (GILSP) processes using genetically modified organisms (GMOs). Biological containment of industrial microorganisms has become a more important issue s
A high containment polymodal pilot-plant fermenter--design concepts.
Hambleton P1, Griffiths JB, Cameron DR, Melling J.
Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986).J Chem Technol Biotechnol.1991;50(2):167-80.
A 225 dm3 pilot-plant bioreactor system has been designed and constructed that is suitable for biohazardous fermentations. The design enables operation at containment levels above the requirements of good industrial large-scale practice (GILSP) without secondary containment of the whole plant. The m