WordNet

arrange in phases or stages; "phase a withdrawal"
(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary; "the reaction occurs in the liquid phase of the system" (同)form
a particular point in the time of a cycle; measured from some arbitrary zero and expressed as an angle (同)phase_angle
any distinct time period in a sequence of events; "we are in a transitional stage in which many former ideas must be revised or rejected" (同)stage
adjust so as to be in a synchronized condition; "he phased the intake with the output of the machine"
(astronomy) the particular appearance of a bodys state of illumination (especially one of the recurring shapes of the part of Earths moon that is illuminated by the sun); "the full phase of the moon"
the 7th letter of the Roman alphabet (同)g

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(変化・発達の)『段階』,『局面』 / (物事の)『面』,様相《+『of』+『名』》 / (月・惑星などの)相 / …‘を'段階的に調整(整理)する

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/26 00:43:01」(JST)

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Many mammal cells, such as this 9x Hneuron, remain permanently or semipermanently in G₀.

The G₀ phase, G zero alpha phase, or 'resting phase' is a period in the cell cycle in which cells exist in a quiescent state. Mammalian cell devision cycle is controlled with extreme precision in order to complete the duplication of the genome and the segregation of replicated chromosome to daughter cells.^[1] G₀ phase is viewed as either an extended G₁ phase, where the cell is neither dividing nor preparing to divide, or a distinct quiescent stage that occurs inside of the cell cycle.^[2] Some types of cells, such as nerve and heart muscle cells, become quiescent when they reach maturity (i.e., when they are terminally differentiated) but continue to perform their main functions for the rest of the organism's life. Multinucleated muscle cells that do not undergo cytokinesis are also often considered to be in the G₀ stage.^[2] On occasion, a distinction in terms is made between a G₀ cell and a 'quiescent' cell (e.g., heart muscle cells and neurons), which will never enter the G₁ phase, whereas other G₀ cells may.

Distinction from senescent cells

Cellular senescence is distinct from quiescence because it is a state that occurs in response to DNA damage or degradation that would make a cell's progeny nonviable. Senescence then, unlike quiescence, is often a biochemical alternative to the self-destruction of such a damaged cell by apoptosis. Furthermore, quiescence is reversible whereas senescence is not.^[3]^[4]

References

^ Matson, Jacob P.; Cook, Jeanette G. (2016-09-16). "Cell cycle proliferation decisions: the impact of single cell analyses". The FEBS journal. doi:10.1111/febs.13898. ISSN 1742-4658. PMID 27634578.
^ ^a ^b Re: Are the cells in the G0 (g zero) phase of mitosis really suspended? Erin Cram, Grad student, Molecular and Cellular Biology, University of California, Berkeley. 1999. MadScience Network. Question ID 942142089.Cb.
^ Blagosklonny, Mikhail (9 February 2011). "Cell cycle arrest is not senescence". Aging (Albany NY). 3 (2): 94–101. doi:10.18632/aging.100281. PMID 3082019. Retrieved 11 November 2016.
^ Beauséjour CM, Krtolica A, Galimi F, et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. The EMBO Journal. 2003;22(16):4212-4222. doi:10.1093/emboj/cdg417.

UpToDate Contents

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1. 陣痛の潜伏相 latent phase of labor
2. 移行期における慢性骨髄性白血病の治療 treatment of chronic myeloid leukemia in accelerated phase
3. 頭頚部癌の放射線抵抗性を克服するための方法 methods to overcome radiation resistance in head and neck cancer
4. 乳房の発達および形態 breast development and morphology
5. 月経随伴性てんかん catamenial epilepsy

English Journal

CircFUT10 reduces proliferation and facilitates differentiation of myoblasts by sponging miR-133a.

Li H1, Yang J1, Wei X1,2, Song C1, Dong D1, Huang Y1, Lan X1, Plath M1, Lei C1, Ma Y2, Qi X3, Bai Y4, Chen H1.
Journal of cellular physiology.J Cell Physiol.2018 Jun;233(6):4643-4651. doi: 10.1002/jcp.26230. Epub 2018 Jan 15.
PMID 29044517

Demethylzeylasteral (ZST93) inhibits cell growth and enhances cell chemosensitivity to gemcitabine in human pancreatic cancer cells via apoptotic and autophagic pathways.

Wang F1,2, Tian X1, Zhang Z1, Ma Y1, Xie X1, Liang J3, Yang C3, Yang Y1.
International journal of cancer.Int J Cancer.2018 May 1;142(9):1938-1951. doi: 10.1002/ijc.31211. Epub 2018 Jan 4.
PMID 29238973

Heterogeneous expression and biological function of SOX18 in osteosaroma.

Zhu D1, Yang D1, Li X1, Feng F1.
Journal of cellular biochemistry.J Cell Biochem.2018 May;119(5):4184-4192. doi: 10.1002/jcb.26635. Epub 2018 Jan 22.
PMID 29266413

Japanese Journal

Erxian Decoction, a traditional Chinese herbal formula, inhibits angiogenesis in human umbilical vein endothelial cells

Yu Xiaobin,Tong Yao,Huang Weihuan,Ge Wei
Biological and Pharmaceutical Bulletin, 2013
… EXD also caused HUVEC apoptosis and cell increase in G0/G1 phase in cell cycle analysis. …
NAID 130003361430

Clitocybin A, a Novel Isoindolinone, From the Mushroom Clitocybe aurantiaca, Inhibits Cell Proliferation Through G1 Phase Arrest by Regulating the PI3K/Akt Cascade in Vascular Smooth Muscle Cells

Yoo Kyu-Dong,Park Eun-Seok,Lim Yong [他],KANG Shin-Il,YOO Su-Hyang,WON Ha-Hee,KIM Young-Hee,YOO Ick-Dong,YOO Hwan-Soo,HONG Jin Tae,YUN Yeo-Pyo
Journal of pharmacological sciences 118(2), 171-177, 2012-02-20
… In accordance with these findings, clitocybin A blocked the PDGF-BB–inducible progression through G0/G1 to S phase of the cell cycle in synchronized cells and decreased the expression of cyclin-dependent kinase (CDK) 2, CDK4, cyclin D1, cyclin E, and proliferative cell nuclear antigen. … These results indicate that clitocybin A may inhibit VSMCs proliferation through G1 phase arrest by regulating the PI3K/Akt pathway. …
NAID 10030454723

Related Pictures

The Cell Cycle 休止期の細胞が増殖能力を維持するための遺伝子を発見－新た G0 phase; Resting Phase This figure shows the different stages of the cell cycle. The G0 phase where the cells G0 Phase of Cell cycle || Why cells enter a G0 phase? - YouTube Which cells enter G0 phases? - Quora The analysis, roles and regulation of quiescence in hematopoietic stem cells | Development G0 Phase; Resting Phase