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English Journal

Revisiting bovine pyometra-New insights into the disease using a culture-independent deep sequencing approach.

Knudsen LR1, Karstrup CC2, Pedersen HG2, Agerholm JS2, Jensen TK3, Klitgaard K3.
Veterinary microbiology.Vet Microbiol.2015 Feb 25;175(2-4):319-24. doi: 10.1016/j.vetmic.2014.12.006. Epub 2014 Dec 19.
The bacteria present in the uterus during pyometra have previously been studied using bacteriological culturing. These studies identified Fusobacterium necrophorum and Trueperella pyogenes as the major contributors to the pathogenesis of pyometra. However, an increasing number of culture-independent
PMID 25550285

The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients.

Sadaghian Sadabad M1, Regeling A2, de Goffau MC3, Blokzijl T4, Weersma RK2, Penders J5, Faber KN2, Harmsen HJ3, Dijkstra G2.
Gut.Gut.2014 Sep 24. pii: gutjnl-2014-307289. doi: 10.1136/gutjnl-2014-307289. [Epub ahead of print]
OBJECTIVE: Crohn's disease (CD) is caused by a complex interplay among genetic, microbial and environmental factors. ATG16L1 is an important genetic factor involved in innate immunity, including autophagy and phagocytosis of microbial components from the gut. We investigated the effect of inflammati
PMID 25253126

Phylogeny and molecular signatures for the phylum Fusobacteria and its distinct subclades.

Gupta RS1, Sethi M2.
Anaerobe.Anaerobe.2014 Aug;28:182-98. doi: 10.1016/j.anaerobe.2014.06.007. Epub 2014 Jun 23.
The members of the phylum Fusobacteria and its two families, Fusobacteriaceae and Leptotrichiaceae, are distinguished at present mainly on the basis of their branching in the 16S rRNA gene trees and analysis of the internal transcribed spacer sequences in the 16S-23S rDNA. However, no biochemical or
PMID 24969840