- 関
- Friend murine leukemia virus
WordNet
- a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
- (virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
- a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
- a person you know well and regard with affection and trust; "he was my best friend at the university"
- a member of the Religious Society of Friends founded by George Fox (the Friends have never called themselves Quakers) (同)Quaker
PrepTutorEJDIC
- ビールス,ろ過性病原体
- 〈C〉友人,友だち / 〈C〉味方,支持者 / 〈C〉役に立つもりの / 〈C〉《F-》フレンド派(Society of Friends)の人,クエーカー教徒(Quaker) / 《丁重な呼びかけ》友よ
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/05/26 11:09:40」(JST)
[Wiki en表示]
Friend virus |
Virus classification |
Group: |
Group VI (ssRNA-RT) |
Family: |
Retroviridae |
Subfamily: |
Orthoretrovirinae |
Genus: |
Gammaretrovirus |
Species: |
Murine leukemia virus |
Serotype |
Friend virus
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The Friend virus (FV) is a strain of murine leukemia virus identified by Charlotte Friend in 1957.[1] The virus infects adult immunocompetent mice and is a well-established model for studying genetic resistance to infection by an immunosuppressive retrovirus. The Friend virus has been used for both immunotherapy and vaccines. It is a member of the retroviridae group of viruses, with its nucleic acid being ssRNA.
Contents
- 1 Vaccination
- 2 Implications
- 3 References
- 4 External links
Vaccination
Experiments have shown that it is possible to protect against Friend virus infection with several types of vaccines, including attenuated viruses, viral proteins, peptides, and recombinant vaccinia vectors expressing the Friend virus gene. In a study of vaccinated mice, it was possible to identify the immunological epitopes required for protection against the virus, thus determining the types of immunological responses necessary or required for protection against it. The research discovered protective epitopes that were localized to F-MuLV gag and env proteins. This was achieved using recombinant vaccinia viruses expressing the gag and env genes of FV.
Implications
Friend virus models showed valuable information regarding genetic resistance to retroviral disease. A particular gene of interest is the Rfv-3 gene, which cause susceptibility to suppression of the FV specific anitbody response. The greater understanding by which the mechanisms work may aid in the development of immunotherapies and vaccines that may be applicable to human diseases.
References
- ^ Friend, C. 1957. Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia. J. Exp. Med., 105; 307-318
External links
- Immunity to retroviral infection: The Friend virus model
- http://www.nap.edu/readingroom.php?book=biomems&page=cfriend.html
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18772436
- http://jem.rupress.org/content/105/4/307.long
Virus: Retroviruses
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|
SsRNA-RT virus |
Retroviridae
|
Alpharetrovirus
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- Avian sarcoma leukosis virus
- Rous sarcoma virus
|
|
Betaretrovirus
|
- Mouse mammary tumor virus
- Jaagsiekte sheep retrovirus
|
|
Deltaretrovirus
|
- Human T-lymphotropic virus (HTLV-1
- HTLV-2, 3, 4)
- Simian-T-lymphotropic virus (types 1-4)
- Bovine leukemia virus
|
|
Epsilonretrovirus
|
- Walleye epidermal hyperplasia virus
|
|
Gammaretrovirus
|
- Murine leukemia virus
- Abelson murine leukemia virus
- Friend virus
- Feline leukemia virus
- Koala retrovirus
- Xenotropic murine leukemia virus-related virus
|
|
Lentivirus
|
- HIV
- Simian immunodeficiency virus
- Feline immunodeficiency virus
- Puma lentivirus
- Equine infectious anemia
- Bovine immunodeficiency virus
- Caprine arthritis encephalitis virus
- Visna virus
|
|
Spumavirus
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- Simian foamy virus
- Human foamy virus
|
|
|
Other
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- Metaviridae
- Pseudoviridae
|
|
|
DsDNA-RT virus |
- Hepadnaviridae (Hepatitis B virus)
- Caulimoviridae
|
|
Endogenous |
- ERVWE1
- HCP5
- Human teratocarcinoma-derived virus
|
|
UpToDate Contents
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English Journal
- Characteristics Associated with HIV Drug Resistance Among Women Screening for an HIV Prevention Trial in KwaZulu-Natal, South Africa.
- Mensch BS1, Gorbach PM, Kelly C, Kiepiela P, Gomez K, Ramjee G, Ganesh S, Morar N, Soto-Torres L, Parikh UM.
- AIDS and behavior.AIDS Behav.2015 May 1. [Epub ahead of print]
- While the expansion of antiretroviral therapy (ART) in sub-Saharan Africa has reduced morbidity and mortality from HIV/AIDS, it has increased concern about drug resistance. The Microbicide Trials Network 009 study assessed the prevalence of drug-resistance mutations among women at clinical sites in
- PMID 25931240
- Role of interleukin-21 in HBV infection: friend or foe?
- Li Y1, Tang L2, Hou J1.
- Cellular & molecular immunology.Cell Mol Immunol.2015 May;12(3):303-308. doi: 10.1038/cmi.2014.109. Epub 2014 Nov 3.
- Interleukin (IL)-21, a cytokine produced by activated CD4+ T cells, has broad pleiotropic actions that affect the functions of a variety of lymphoid cells. The roles of IL-21 in modulating immunity to infections are currently being defined. Notably, IL-21-mediated cellular and humoral immune respons
- PMID 25363528
- Social Support and Human Immunodeficiency Virus-Status Disclosure to Friends and Family: Implications for Human Immunodeficiency Virus-Positive Youth.
- Lee S1, Yamazaki M2, Harris DR3, Harper GW4, Ellen J5.
- The Journal of adolescent health : official publication of the Society for Adolescent Medicine.J Adolesc Health.2015 May 1. pii: S1054-139X(15)00085-3. doi: 10.1016/j.jadohealth.2015.03.002. [Epub ahead of print]
- PURPOSE: The fear of negative reactions from friends and family members affects many human immunodeficiency virus (HIV)-positive adolescents' decisions regarding disclosure of their HIV status. The complex relationships and interplay among social support, fear of stigma, and disclosure of HIV status
- PMID 25940217
Japanese Journal
- Polyadenylation of Friend murine leukemia virus env-mRNA is affected by its splicing
- A 38 nt region and its flanking sequences within gag of Friend murine leukemia virus are crucial for splicing at the correct 5' and 3' splice sites
- Kinetic studies of the effect of a 17-nucleotide difference in the 0.3-kb region containing the R-U5-5' leader sequence of Friend murine leukemia virus on viral gene expression
Related Links
- FRIEND VIRUS Bogus facebook terminal exhaustion of whole hard disk c replication. Polar friend sure if you have you have been prepared. Recovery, as electron microscope and rauscher. Circulation of different aug . Friending virus ...
- frend n a strain of murine leukemia virus that causes erythroleukemia in mice called also Friend leukemia virus Friend Charlotte (1921 1987) American microbiologist. Friend served as professor and director of the center for ...
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