WordNet
- a substance (an atom or molecule or radical or ion) that forms a complex around a central atom
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/14 06:49:04」(JST)
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Fms-related tyrosine kinase 3 ligand |
PDB rendering based on 1ete. |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
1ETE, 3QS7, 3QS9
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Identifiers |
Symbols |
FLT3LG; FL; FLT3L |
External IDs |
OMIM: 600007 MGI: 95560 HomoloGene: 48021 GeneCards: FLT3LG Gene |
Gene Ontology |
Molecular function |
• receptor binding
• cytokine activity
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Cellular component |
• extracellular space
• plasma membrane
• membrane
• integral to membrane
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Biological process |
• signal transduction
• positive regulation of cell proliferation
• embryonic hemopoiesis
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
2323 |
14256 |
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Ensembl |
ENSG00000090554 |
ENSMUSG00000089989 |
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UniProt |
P49771 |
P49772 |
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RefSeq (mRNA) |
NM_001204502.1 |
NM_013520.3 |
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RefSeq (protein) |
NP_001191431.1 |
NP_038548.3 |
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Location (UCSC) |
Chr 19:
49.98 – 49.99 Mb |
Chr 7:
45.13 – 45.14 Mb |
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PubMed search |
[1] |
[2] |
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Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene.[1][2][3]
Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors.
References
- ^ "Entrez Gene: FLT3LG fms-related tyrosine kinase 3 ligand". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2323.
- ^ Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J (April 1994). "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs". Nature 368 (6472): 643–8. doi:10.1038/368643a0. PMID 8145851.
- ^ Lyman SD, James L, Escobar S, Downey H, de Vries P, Brasel K, Stocking K, Beckmann MP, Copeland NG, Cleveland LS (January 1995). "Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs". Oncogene 10 (1): 149–57. PMID 7824267.
Further reading
- Lyman SD, James L, Vanden Bos T et al. (1994). "Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells". Cell 75 (6): 1157–67. doi:10.1016/0092-8674(93)90325-K. PMID 7505204.
- Lyman SD, Stocking K, Davison B et al. (1995). "Structural analysis of human and murine flt3 ligand genomic loci". Oncogene 11 (6): 1165–72. PMID 7566977.
- Lyman SD, James L, Escobar S et al. (1995). "Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs". Oncogene 10 (1): 149–57. PMID 7824267.
- Hannum C, Culpepper J, Campbell D et al. (1994). "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs". Nature 368 (6472): 643–8. doi:10.1038/368643a0. PMID 8145851.
- Lyman SD, James L, Johnson L et al. (1994). "Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells". Blood 83 (10): 2795–801. PMID 8180375.
- Slanicka Krieger M, Nissen C, Manz CY et al. (1998). "The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow". Exp. Hematol. 26 (5): 365–73. PMID 9590652.
- Graddis TJ, Brasel K, Friend D et al. (1998). "Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen". J. Biol. Chem. 273 (28): 17626–33. doi:10.1074/jbc.273.28.17626. PMID 9651358.
- Solanilla A, Grosset C, Lemercier C et al. (2000). "Expression of Flt3-ligand by the endothelial cell". Leukemia 14 (1): 153–62. doi:10.1038/sj.leu.2401635. PMID 10637491.
- Savvides SN, Boone T, Karplus P.A. (2000). "Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots". Nat. Struct. Biol. 7 (6): 486–91. doi:10.1038/75896. PMID 10881197.
- Chklovskaia E, Nissen C, Landmann L et al. (2001). "Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor gamma-chain signaling and inhibited by cyclosporin A". Blood 97 (4): 1027–34. doi:10.1182/blood.V97.4.1027. PMID 11159533.
- Agrawal DK, Hopfenspirger MT, Chavez J, Talmadge JE (2002). "Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model". Int. Immunopharmacol. 1 (12): 2081–9. doi:10.1016/S1567-5769(01)00122-9. PMID 11710537.
- Li H, Cai Y, Xu J (2002). "[Localization of a FLT3 ligand isoform in human tissues]". Zhonghua Xue Ye Xue Za Zhi 20 (6): 285–7. PMID 11721383.
- Feugier P, Jo DY, Shieh JH et al. (2003). "Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand". J. Hematother. Stem Cell Res. 11 (1): 127–38. doi:10.1089/152581602753448595. PMID 11847009.
- O'Keeffe M, Hochrein H, Vremec D et al. (2002). "Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice". Blood 99 (6): 2122–30. doi:10.1182/blood.V99.6.2122. PMID 11877288.
- Retzlaff S, Padró T, Koch P et al. (2002). "Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma". Oncol. Rep. 9 (3): 525–7. PMID 11956621.
- Sigurjónsson OE, Gudmundsson KO, Haraldsdóttir V et al. (2003). "Flt3/Flk-2-ligand in synergy with thrombopoietin delays megakaryocyte development and increases the numbers of megakaryocyte progenitor cells in serum-free cultures initiated with CD34+ cells". J. Hematother. Stem Cell Res. 11 (2): 389–400. doi:10.1089/152581602753658574. PMID 11983110.
- Vávrová J, Vokurková D, Mareková M et al. (2002). "Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells". Folia Biol. (Praha) 48 (2): 51–7. PMID 12002675.
- Testa U, Torelli GF, Riccioni R et al. (2002). "Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors". Blood 99 (12): 4634–7. doi:10.1182/blood.V99.12.4634. PMID 12036900.
- Mosca PJ, Hobeika AC, Colling K et al. (2002). "Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand". J. Leukoc. Biol. 72 (3): 546–53. PMID 12223523.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
PDB gallery
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1ete: CRYSTAL STRUCTURE OF THE FLT3 LIGAND
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Regulome
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Activates |
MAP kinase, FLT3, STAT5A
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Inhibits |
tyrosine kinase, PSA
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UpToDate Contents
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- 1. 組換え造血成長因子の概要 introduction to recombinant hematopoietic growth factors
- 2. 急性骨髄性白血病の予後 prognosis of acute myeloid leukemia
- 3. 骨髄造血の制御 regulation of myelopoiesis
- 4. 幹細胞および前駆細胞の動員における組換え造血成長因子の使用 use of recombinant hematopoietic growth factors in stem cell and progenitor cell mobilization
- 5. 造血幹細胞の分布 sources of hematopoietic stem cells
English Journal
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- Duraiswamy J, Freeman GJ, Coukos G.SourceAuthors' Affiliations: Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and Department of Oncology and Ludwig Center for Cancer Research, University Hospital of Lausanne, Lausanne, Switzerland.
- Cancer research.Cancer Res.2013 Dec 1;73(23):6900-12. doi: 10.1158/0008-5472.CAN-13-1550. Epub 2013 Aug 23.
- The tumor microenvironment mediates induction of the immunosuppressive programmed cell death-1 (PD-1) pathway, and targeted interventions against this pathway can help restore antitumor immunity. To gain insight into these responses, we studied the interaction between PD-1 expressed on T cells and i
- PMID 23975756
- Characterization of CD56(+) Dendritic-Like Cells: A Normal Counterpart of Blastic Plasmacytoid Dendritic Cell Neoplasm?
- Osaki Y, Yokohama A, Saito A, Tahara K, Yanagisawa K, Ogawa Y, Ishizaki T, Mitsui T, Koiso H, Takizawa M, Uchiumi H, Saitoh T, Handa H, Murakami H, Tsukamoto N, Nojima Y.SourceDepartment of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
- PloS one.PLoS One.2013 Nov 29;8(11):e81722. doi: 10.1371/journal.pone.0081722.
- Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy. Plasmacytoid DCs (pDCs), which are defined as lineage marker (Lin)(-)HLA-DR(+)CD56(-)CD123(+)CD11c(-) cells, are considered to be the normal counterpart of BPDCNs. However, BPDCN can be distinguished from pDCs b
- PMID 24312342
- Generation of hematopoietic stem cells from purified embryonic endothelial cells by a simple and efficient strategy.
- Li Z, Zhou F, Chen D, He W, Ni Y, Luo L, Liu B.SourceKey Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Laboratory of Molecular Developmental Biology, School of Life Science, Southwest University, Chongqing 400715, China; 307-Ivy Translational Medicine Center, Laboratory of Oncology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China.
- Journal of genetics and genomics = Yi chuan xue bao.J Genet Genomics.2013 Nov 20;40(11):557-63. doi: 10.1016/j.jgg.2013.09.001. Epub 2013 Sep 20.
- Recent progress by versatile approaches supports the new hypothesis that multi-potent hematopoietic stem cells (HSCs) are directly formed from a rare population of endothelial cells in mid-gestation mouse embryos. This process is therefore known as the endothelial-to-hematopoietic transition (EHT).
- PMID 24238609
Japanese Journal
- Enhanced expression of mRNA for FLT3 in bone marrow CD34+ cells in rheumatoid arthritis
- P7-036 全身性強皮症患者における血清Flt3 Ligand値と臨床相関の検討
- Regulation of Preimplantation Embryo Development in Mice by FMS-like Tyrosine Kinase 3 Ligand
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