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English Journal

Calpain regulates thymidylate synthase-5-fluoro-dUMP complex levels associated with response to 5-fluorouracil in gastric cancer cells.

Nabeya Y, Suzuki T, Furuya A, Koide N, Ohkoshi M, Takiguchi M, Ochiai T, Matsubara H, Hiwasa T.SourceDivision of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan. ynabeya@chiba-cc.jp
Cancer science.Cancer Sci.2011 Aug;102(8):1509-15. doi: 10.1111/j.1349-7006.2011.01978.x. Epub 2011 Jun 23.
Thymidylate synthase (TS) plays a major role in the response to 5-fluorouracil (5-FU) by binding directly to the 5-FU metabolite, 5-fluoro-dUMP (FdUMP). The change in the TS expression levels after 5-FU administration was examined in parallel to 5-FU responsiveness in six human gastric adenocarcinom
PMID 21561529