- 同
- 成人病胎児期起源説
参考
- Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales.
- Barker DJ, Osmond C.AbstractAlthough the rise in ischaemic heart disease in England and Wales has been associated with increasing prosperity, mortality rates are highest in the least affluent areas. On division of the country into two hundred and twelve local authority areas a strong geographical relation was found between ischaemic heart disease mortality rates in 1968-78 and infant mortality in 1921-25. Of the twenty-four other common causes of death only bronchitis, stomach cancer, and rheumatic heart disease were similarly related to infant mortality. These diseases are associated with poor living conditions and mortality from them is declining. Ischaemic heart disease is strongly correlated with both neonatal and postneonatal mortality. It is suggested that poor nutrition in early life increases susceptibility to the effects of an affluent diet.
- Lancet.Lancet.1986 May 10;1(8489):1077-81.
- Although the rise in ischaemic heart disease in England and Wales has been associated with increasing prosperity, mortality rates are highest in the least affluent areas. On division of the country into two hundred and twelve local authority areas a strong geographical relation was found between isc
- PMID 2871345
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- 病胎児期発症(起源)説:FOAD:Fetal Ori-gins of Adult Disease」である웋웦워웗。その機序は、 遺伝子配列に差が無くても、胎生期で臓器形成や 代謝系の形成される臨界期に、低栄養または過量 栄養に暴露されることで、DNA ...
- て世界的に認められるに至っている.このFOAD説はその概念を拡大して,疾病および 健康は胎生期を中心とした極めて初期にその素因が形成されるというDevelopmental OriginsofHealthandDisease(DOHaD)学説に発展している.この ...
- しかしこのFOAD説は更にその考え方や概念を拡大して、健康や疾病は胎芽、胎児、新生児期に素因が決定されるとしてDevelopmental Origins of Health and Disease(DOHaD :ドーハッド)説といわれるにいたって 4) ...
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