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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/12 13:36:52」(JST)

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Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster of differentiation 334).

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.^[1]

Interactions

Fibroblast growth factor receptor 4 has been shown to interact with FGF1.^[2]^[3]

References

^ "Entrez Gene: FGFR4 fibroblast growth factor receptor 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2264.
^ Loo, B B; Darwish K K, Vainikka S S, Saarikettu J J, Vihko P P, Hermonen J J, Goldman A A, Alitalo K K, Jalkanen M M (May. 2000). "Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4". Int. J. Biochem. Cell Biol. (ENGLAND) 32 (5): 489–97. doi:10.1016/S1357-2725(99)00145-4. ISSN 1357-2725. PMID 10736564.
^ Kan, M; Wu X, Wang F, McKeehan W L (May. 1999). "Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase". J. Biol. Chem. (UNITED STATES) 274 (22): 15947–52. doi:10.1074/jbc.274.22.15947. ISSN 0021-9258. PMID 10336501.

External links

FGFR4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 鞍部腫瘤の原因、症状、および評価 causes presentation and evaluation of sellar masses
2. 先端巨大症の原因および臨床症状 causes and clinical manifestations of acromegaly

English Journal

A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation.

Benzina S1, Pitaval A, Lemercier C, Lustremant C, Frouin V, Wu N, Papine A, Soussaline F, Romeo PH, Gidrol X.
Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2015 Sep;72(18):3559-73. doi: 10.1007/s00018-015-1901-7. Epub 2015 Apr 18.
A general radioprotective effect by fibroblast growth factor (FGF) has been extensively described since the early 1990s; however, the molecular mechanisms involved remain largely unknown. Radiation-induced DNA double-strand breaks (DSBs) lead to a complex set of responses in eukaryotic cells. One of
PMID 25894690

FGF23 regulation of renal tubular solute transport.

Erben RG1, Andrukhova O.
Current opinion in nephrology and hypertension.Curr Opin Nephrol Hypertens.2015 Sep;24(5):450-6. doi: 10.1097/MNH.0000000000000145.
PURPOSE OF REVIEW: Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress phosphate reabsorption in the kidney. The purpose of this review was to highlight the recent advances in the area of FGF23-regulated solute transport in the kidney.RECENT FINDINGS: Recent evidence sugg
PMID 26125643

Exploratory analysis of candidate germline gene polymorphisms in breast cancer patients treated with neoadjuvant anthracycline-containing chemotherapy and associations with febrile neutropenia.

Charehbili A1,2, Groot S1, der Straaten TV3, Swen JJ3, Pijl H4, Gelderblom H1, de Velde CV2, Nortier J1, Guchelaar HJ3, Kroep JR1.
Pharmacogenomics.Pharmacogenomics.2015 Aug 20:1-10. [Epub ahead of print]
AIM: SNPs may be associated with (side) effects of chemotherapy and may be useful as biomarkers to predict febrile neutropenia.PATIENTS & METHODS: 187 DNA samples extracted from formalin-fixed paraffin-embedded tissue from patients with stage II/III HER2-negative breast cancer were genotyped.RES
PMID 26289095

Japanese Journal

マウス胚性幹細胞由来の神経幹細胞に対する増殖因子の効果

吉江拓也,大森啓之,大津昌弘,柴田雅祥,中山孝,井上順雄
日本保健科学学会誌 16(4), 201-209, 2014-03-25
神経幹細胞は自己複製能と多分化能をもつ未分化な細胞である。本研究では,マウス胚性幹(ES)細胞からNeural Stem Sphere(NSS)法により調製した神経幹細胞に対する,線維芽細胞増殖因子-2(FGF-2)と上皮増殖因子(EGF)の影響を解析した。FGF-2およびEGFは濃度依存的に神経幹細胞の増殖を促進した。FGF-2はEGFより神経幹細胞への親和性が低いが,細胞増殖能は高く,両者の効 …
NAID 110009809402

The involvement of fibroblast growth factor receptor signaling pathways in dermatofibroma and dermatofibrosarcoma protuberans

Ishigami Takeshi,Hida Yasutoshi,Matsudate Yoshihiro,Murao Kazutoshi,Kubo Yoshiaki
The journal of medical investigation : JMI 60(1-2), 106-113, 2013-02
… In addition, strong expression of FGF2 and FGFR4 was observed in the tumor lesions of DF. … Expression patterns of FGFR3/FOXN1 and FGF2/FGFR4 in DF were in contrast with those of DFSP. …
NAID 120005380904

The involvement of fibroblast growth factor receptor signaling pathways in dermatofibroma and dermatofibrosarcoma protuberans

Ishigami Takeshi,Hida Yasutoshi,Matsudate Yoshihiro,Murao Kazutoshi,Kubo Yoshiaki
The Journal of Medical Investigation 60(1.2), 106-113, 2013
… In addition, strong expression of FGF2 and FGFR4 was observed in the tumor lesions of DF. … Expression patterns of FGFR3/FOXN1 and FGF2/FGFR4 in DF were in contrast with those of DFSP. …
NAID 130004465277

Related Pictures

Fgfr4 Mutations Immunohistochemistry-Paraffin: FGFR4 - FGFR4 antibody (ab41948 Fig. 4. /Immunofluorescence: FGFR4 Protein Guild Wars 2 Map Completion Checklist

★リンクテーブル★

リンク元	「線維芽細胞増殖因子受容体4」「type 4 fibroblast growth factor receptor」
関連記事	「FGF」

「線維芽細胞増殖因子受容体4」

Fibroblast growth factor receptor 4
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1QCT
Identifiers
Symbols	FGFR4; CD334; JTK2; TKF
External IDs	OMIM: 134935 MGI: 95525 HomoloGene: 20461 ChEMBL: 3973 GeneCards: FGFR4 Gene
EC number	2.7.10.1
Gene Ontology
Molecular function	• protein tyrosine kinase activity; • fibroblast growth factor-activated receptor activity; • ATP binding; • heparin binding; • fibroblast growth factor binding;
Cellular component	• extracellular region; • nucleus; • nucleolus; • cytoplasm; • endosome; • endoplasmic reticulum; • plasma membrane; • integral to plasma membrane; • cell-cell junction;
Biological process	• organ induction; • positive regulation of cell proliferation; • insulin receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • regulation of extracellular matrix disassembly; • cell migration; • peptidyl-tyrosine phosphorylation; • regulation of lipid metabolic process; • glucose homeostasis; • positive regulation of proteolysis; • protein autophosphorylation; • positive regulation of metalloenzyme activity; • phosphate ion homeostasis; • alveolar secondary septum development; • positive regulation of ERK1 and ERK2 cascade; • regulation of bile acid biosynthetic process; • regulation of cholesterol homeostasis; • positive regulation of DNA biosynthetic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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