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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/06/14 07:54:30」(JST)

English Journal

Identification of Potential Inhibitors for AIRS from de novo purine biosynthesis pathway through Molecular modeling Studies - A Computational approach.

Guru Raj Rao R1, Biswal J1, Prabhu D1, Sureka K1, Jeyakanthan J1.
Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2015 Nov 2:1-51. [Epub ahead of print]
In cancer, de novo pathway plays an important role in cell proliferation by supplying huge demand of purine nucleotides. Aminoimidazole ribonucleotide synthetase (AIRS) catalyzes the fifth step of de novo purine biosynthesis facilitating in the conversion of Formylglycinamidine Ribonucleotide (FGAM)
PMID 26524231

Crystal structures and ligand binding of PurM proteins from Thermus thermophilus and Geobacillus kaustophilus.

Kanagawa M1, Baba S2, Watanabe Y3, Nakagawa N4, Ebihara A1, Kuramitsu S5, Yokoyama S1, Sampei GI6, Kawai G7.
Journal of biochemistry.J Biochem.2015 Oct 29. pii: mvv107. [Epub ahead of print]
Crystal structures of 5-aminoimidazole ribonucleotide (AIR) synthetase, also known as PurM, from Thermus thermophilus (Tt) and Geobacillus kaustophilus (Gk) were determined. For TtPurM, the maximum resolution was 2.2 Å and the space group was P21212 with four dimers in an asymmetric unit. For GkPur
PMID 26515187

McLean MW1, Hooker G2, Staicu AM3, Scheipl F4, Ruppert D5.
Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America.J Comput Graph Stat.2014;23(1):249-269.
We introduce the functional generalized additive model (FGAM), a novel regression model for association studies between a scalar response and a functional predictor. We model the link-transformed mean response as the integral with respect to t of F{X(t), t} where F(·,·) is an unknown regression fu
PMID 24729671

リンク元	「ホルミルグリシンアミジンリボチド」

5'-Phosphoribosylformylglycinamidine
Names
	IUPAC name [(2R,3S,4R,5R)-5-[(1-Amino-2-formamidoethylidene)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Identifiers
CAS Number	6157-85-3;
3D model (JSmol)	Interactive image; Interactive image;
ChemSpider	17216355 ;
PubChem CID	5462266;
	InChI InChI=1S/C6H12N3O8P/c7-6(8-1-10)9-4-2(11)3(12)5(16-4)17-18(13,14)15/h1-5,11-12H,(H2,13,14,15)(H3,7,8,9,10)/t2-,3+,4-,5-/m1/s1 Key: OKXISSDNJVDCJE-KKQCNMDGSA-N ; InChI=1/C6H12N3O8P/c7-6(8-1-10)9-4-2(11)3(12)5(16-4)17-18(13,14)15/h1-5,11-12H,(H2,13,14,15)(H3,7,8,9,10)/t2-,3+,4-,5-/m1/s1 Key: OKXISSDNJVDCJE-KKQCNMDGBB ;
	SMILES C([C@@H]1[C@H]([C@H]([C@@H](O1)/N=C(/CNC=O)\N)O)O)OP(=O)(O)O ; O[C@H]1[C@@H](O)[C@H](NC(=N)NC=O)O[C@@H]1OP(=O)(O)O ;
Properties
Chemical formula	C8H16N3O8P
Molar mass	313.20 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references