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- crotamiton
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/16 00:53:29」(JST)
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Crotamiton
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Systematic (IUPAC) name |
(E)-N-Ethyl-N-(2-methylphenyl)but-2-enamide[1]
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Clinical data |
AHFS/Drugs.com |
monograph |
Pregnancy
category |
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Identifiers |
CAS Registry Number |
483-63-6 Y |
ATCvet code |
QP53AX04 |
PubChem |
CID: 688020 |
DrugBank |
DB00265 Y |
ChemSpider |
599515 Y |
UNII |
D6S4O4XD0H Y |
KEGG |
D01381 Y |
ChEMBL |
CHEMBL1200709 N |
Chemical data |
Formula |
C13H17NO |
Molecular mass |
203.28 g/mol |
SMILES
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O=C(N(c1ccccc1C)CC)/C=C/C
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InChI
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InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+ Y
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Key:DNTGGZPQPQTDQF-XBXARRHUSA-N Y
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N (what is this?) (verify) |
Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic (anti-itching drug). It is a prescription lotion based medicine that is applied to the whole body to get rid of the scabies parasite that burrows under the skin and causes itching.
Contents
- 1 Use
- 2 Pharmacology
- 3 Pharmacokinetics
- 4 Side effects
- 5 Trade name
- 6 References
Use
For treating scabies, crotamiton should be applied to the whole body rather than a localized area. It is applied 2 to 3 times, with a 24-hour delay in between applications, and the patient is asked to take a shower no sooner than after 48 hours. For children under 3 years it is applied once daily. Crotamiton can also be used to treat itching stemming from other causes, e.g. insect bites, in which case it is applied to the itching areas only, and repeated if necessary after 4 to 8 hours. Use near the eyes, or breaks in the skin, should be avoided.
Pharmacology
The mechanism of action of crotamiton is unknown,however it is toxic to the scabies mite.[2]
Pharmacokinetics
After topical application, crotamiton is absorbed systemically. It has an elimination half-life of 30.9 hours and 4.8-8.8% is excreted in the urine.[3]
Side effects
The most common side effect of crotamiton is skin irritation.
Trade name
Crotamiton is marketed under the trade names Eurax, which is manufactured by Ranbaxy Laboratories in the USA, and Novartis in the UK, and Euracin, which is manufactured by Green Cross in South Korea. In Germany, it is marketed under the brand name, Crotamitex. In India it's sold as Eurax by Ranbaxy Laboratories
References
- ^ Crotamiton at alanwood.net
- ^ Medscape drug information - mechanism of action
- ^ Medscape drug information - pharmacokinetics
Ectoparasiticides / arthropod (P03A)
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Insecticide/pediculicide |
Chlorine-containing products
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Chloride channel
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Organophosphate
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Acaricide/miticide/scabicide |
Pyrethrines
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- Permethrin#
- Pyrethrum
- Phenothrin
- Bioallethrin
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Chloride channel
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Sulfur-containing products
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- Disulfiram
- Dixanthogen
- Mesulfen
- Thiram
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Chlorine-containing products
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Benzoate
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Organophosphate
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Other/ungrouped
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- Dimethicone
- Quassia
- toluidine (Crotamiton)
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of parasites and pests
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Description |
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Disease |
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Treatment |
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UpToDate Contents
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English Journal
- Assessment of Groundwater Pollution in Tokyo Using PPCPs as Sewage Markers.
- Kuroda K, Murakami M, Oguma K, Muramatsu Y, Takada H, Takizawa S.SourceDepartment of Urban Engineering, Graduate School of Engineering, The University of Tokyo , 7-3-1 Hongo, Bunkyo, Tokyo, 113-8656, Japan.
- Environmental science & technology.Environ Sci Technol.2012 Feb 7;46(3):1455-64. Epub 2012 Jan 20.
- While the occurrence of pharmaceuticals and personal care products (PPCPs) in groundwater has typically been reported in bank filtration sites, irrigated fields, septic tanks, and sewage disposal practices, fewer studies have been conducted in highly urbanized areas, where infiltration of treated or
- PMID 22191375
- Nationwide monitoring of selected antibiotics: Distribution and sources of sulfonamides, trimethoprim, and macrolides in Japanese rivers.
- Murata A, Takada H, Mutoh K, Hosoda H, Harada A, Nakada N.SourceLaboratory of Organic Geochemistry (LOG), Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
- The Science of the total environment.Sci Total Environ.2011 Nov 15;409(24):5305-12. Epub 2011 Oct 4.
- We report the results of a nationwide survey of commonly used human and veterinary antibiotics (7 sulfonamides, trimethoprim, and 4 macrolides) in 37 Japanese rivers. Concentrations of the sum of the 12 target antibiotics ranged from undetectable to 626 ng/L, with a median of 7.3 ng/L for the 37 riv
- PMID 21975006
Japanese Journal
- 疥癬患者におけるイベルメクチンの安全性および投与回数についての検討
- 清水平 ちひろ,江川 裕美,近藤 摂子
- 皮膚の科学 8(5), 527-533, 2009
- 2008年4月から同10月までの当院入院症例のうち,疥癬40例に対してイベルメクチン投与と安息香酸ベンジルオイラックス外用を行った。全例が65歳以上であった。イベルメクチン投与中および投与後に有害事象を認めた症例は臨床検査値異常が5例,基礎疾患によると考えられる死亡例が2例あった。このうち臨床検査値異常の5例はいずれも無治療で正常化した。軽度の肝障害を認めた2例に対してもイベルメクチンの内服治療を …
- NAID 130004934546
- 症例報告 オイラックスの香料による接触皮膚炎の1例
- 武曽 有美,城村 拓也,坂井 浩志,調 裕次,高木 圭一
- 皮膚の科学 6(2), 191-194, 2007
- 近年,高齢者が介護施設で集団生活をする機会が増えたことに伴って疥癬の流行が認められる。<BR>また疥癬の治療薬にはさまざまなものがあり,最近,内服薬も保険適応となった。しかし,必要時にこれら薬剤の入手が容易とは限らず,副作用の問題から妊婦や小児には使用しにくいものも多い。そこでわれわれはイオウを含有し,安価で多くの施設で採用されているイオウ・カンフルローションを,計7名の疥癬患者に用い …
- NAID 130004547236
Related Links
- Learn about the prescription medication Eurax (Crotamiton Cream, Lotion), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. ... What are the possible side effects of crotamiton (Eurax)? ...
- Eurax is an anti-pruritic cream that delivers fast and effective relief from itching due to dermatosis, scabies, insect bites, poison ivy, and dermatitis. ... Adverse effects Medicines and their possible side effects can affect individual ...
Related Pictures
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