関: crotamiton

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/16 00:53:29」(JST)

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Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic (anti-itching drug). It is a prescription lotion based medicine that is applied to the whole body to get rid of the scabies parasite that burrows under the skin and causes itching.

Use

For treating scabies, crotamiton should be applied to the whole body rather than a localized area. It is applied 2 to 3 times, with a 24-hour delay in between applications, and the patient is asked to take a shower no sooner than after 48 hours. For children under 3 years it is applied once daily. Crotamiton can also be used to treat itching stemming from other causes, e.g. insect bites, in which case it is applied to the itching areas only, and repeated if necessary after 4 to 8 hours. Use near the eyes, or breaks in the skin, should be avoided.

Pharmacology

The mechanism of action of crotamiton is unknown,however it is toxic to the scabies mite.^[2]

Pharmacokinetics

After topical application, crotamiton is absorbed systemically. It has an elimination half-life of 30.9 hours and 4.8-8.8% is excreted in the urine.^[3]

Side effects

The most common side effect of crotamiton is skin irritation.

Trade name

Crotamiton is marketed under the trade names Eurax, which is manufactured by Ranbaxy Laboratories in the USA, and Novartis in the UK, and Euracin, which is manufactured by Green Cross in South Korea. In Germany, it is marketed under the brand name, Crotamitex. In India it's sold as Eurax by Ranbaxy Laboratories

References

^ Crotamiton at alanwood.net
^ Medscape drug information - mechanism of action
^ Medscape drug information - pharmacokinetics

UpToDate Contents

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1. 疥癬 scabies
2. ケジラミ症と眼瞼ケジラミ症 pediculosis pubis and pediculosis ciliaris
3. 酒さ：病因、臨床的特徴、および診断 rosacea pathogenesis clinical features and diagnosis

English Journal

Assessment of Groundwater Pollution in Tokyo Using PPCPs as Sewage Markers.

Kuroda K, Murakami M, Oguma K, Muramatsu Y, Takada H, Takizawa S.SourceDepartment of Urban Engineering, Graduate School of Engineering, The University of Tokyo , 7-3-1 Hongo, Bunkyo, Tokyo, 113-8656, Japan.
Environmental science & technology.Environ Sci Technol.2012 Feb 7;46(3):1455-64. Epub 2012 Jan 20.
While the occurrence of pharmaceuticals and personal care products (PPCPs) in groundwater has typically been reported in bank filtration sites, irrigated fields, septic tanks, and sewage disposal practices, fewer studies have been conducted in highly urbanized areas, where infiltration of treated or
PMID 22191375

Nationwide monitoring of selected antibiotics: Distribution and sources of sulfonamides, trimethoprim, and macrolides in Japanese rivers.

Murata A, Takada H, Mutoh K, Hosoda H, Harada A, Nakada N.SourceLaboratory of Organic Geochemistry (LOG), Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
The Science of the total environment.Sci Total Environ.2011 Nov 15;409(24):5305-12. Epub 2011 Oct 4.
We report the results of a nationwide survey of commonly used human and veterinary antibiotics (7 sulfonamides, trimethoprim, and 4 macrolides) in 37 Japanese rivers. Concentrations of the sum of the 12 target antibiotics ranged from undetectable to 626 ng/L, with a median of 7.3 ng/L for the 37 riv
PMID 21975006

Japanese Journal

疥癬患者におけるイベルメクチンの安全性および投与回数についての検討

清水平ちひろ,江川裕美,近藤摂子
皮膚の科学 8(5), 527-533, 2009
2008年4月から同10月までの当院入院症例のうち，疥癬40例に対してイベルメクチン投与と安息香酸ベンジルオイラックス外用を行った。全例が65歳以上であった。イベルメクチン投与中および投与後に有害事象を認めた症例は臨床検査値異常が5例，基礎疾患によると考えられる死亡例が2例あった。このうち臨床検査値異常の5例はいずれも無治療で正常化した。軽度の肝障害を認めた2例に対してもイベルメクチンの内服治療を …
NAID 130004934546

症例報告オイラックスの香料による接触皮膚炎の1例

奥野公成,角田孝彦
臨床皮膚科 61(7), 493-495, 2007-06
NAID 40015518585

イオウ・カンフルローションを用いた疥癬治療の試み

武曽有美,城村拓也,坂井浩志,調裕次,高木圭一
皮膚の科学 6(2), 191-194, 2007
近年，高齢者が介護施設で集団生活をする機会が増えたことに伴って疥癬の流行が認められる。<BR>また疥癬の治療薬にはさまざまなものがあり，最近，内服薬も保険適応となった。しかし，必要時にこれら薬剤の入手が容易とは限らず，副作用の問題から妊婦や小児には使用しにくいものも多い。そこでわれわれはイオウを含有し，安価で多くの施設で採用されているイオウ・カンフルローションを，計7名の疥癬患者に用い …
NAID 130004547236

Related Pictures

Drugs reference index « Eurax » EURAX Crème Tube de 40g Medicine Skin Diseases Eurax Lotion 50Ml Medicine Skin Diseases Eurax Cream 60Gm Eurax Cream Generic

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リンク元

「クロタミトン」

Crotamiton
Systematic (IUPAC) name
	(E)-N-Ethyl-N-(2-methylphenyl)but-2-enamide
Clinical data
AHFS/Drugs.com	monograph
Pregnancy; category	C;
Identifiers
CAS Registry Number	483-63-6
ATCvet code	QP53AX04
PubChem	CID: 688020
DrugBank	DB00265
ChemSpider	599515
UNII	D6S4O4XD0H
KEGG	D01381
ChEMBL	CHEMBL1200709
Chemical data
Formula	C13H17NO
Molecular mass	203.28 g/mol
	SMILES O=C(N(c1ccccc1C)CC)/C=C/C ;
	InChI InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+ ; Key:DNTGGZPQPQTDQF-XBXARRHUSA-N ;
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　　[★]

英: crotamiton
商: オイラックスH、オイラックス、キンダロン、グリメサゾン、ケトコナゾール、サイベース、マイアロン、Eurax

外用かゆみ止め

[1] Crotamiton at alanwood.net

[2] Medscape drug information - mechanism of action

[3] Medscape drug information - pharmacokinetics

匿名

検索

案内

案内

Eurax