Lentivirus escape from neutralizing antibodies (NAbs) is not well understood. In this work, we quantified antibody escape of a lentivirus, using antibody escape data from horses infected with equine infectious anemia virus. We calculated antibody blocking rates of wild-type virus, fitness costs of m
Proteomic alteration of equine monocyte-derived macrophages infected with equine infectious anemia virus.
Du C1,2, Liu HF1, Lin YZ1, Wang XF1, Ma J1, Li YJ2, Wang X1, Zhou JH1,3.
Proteomics.Proteomics.2015 Jun;15(11):1843-58. doi: 10.1002/pmic.201400279. Epub 2015 Mar 21.
Similar to the well-studied viruses human immunodeficiency virus (HIV)-1 and simian immunodeficiency virus (SIV), equine infectious anemia virus (EIAV) is another member of the Lentivirus genus in the family Retroviridae. Previous studies revealed that interactions between EIAV and the host resulted
Structural insight into equine lentivirus receptor 1.
Qian L1, Han X, Liu X.
Protein science : a publication of the Protein Society.Protein Sci.2015 May;24(5):633-42. doi: 10.1002/pro.2634. Epub 2015 Jan 28.
Equine lentivirus receptor 1 (ELR1) has been identified as a functional cellular receptor for equine infectious anemia virus (EIAV). Herein, recombinant ELR1 and EIAV surface glycoprotein gp90 were respectively expressed in Drosophila melanogaster S2 cells, and purified to homogeneity by Ni-NTA affi