English Journal

[Effects of 1,3-diphenyl-1,3-propanedione on neurotransmitter contents of brain in mice administered with cocaine].

Chen J1, Wang YC1, Cui R1, Liu XX2, Zhang BX2.
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.Beijing Da Xue Xue Bao.2016 Jun 18;48(3):398-402.
OBJECTIVE: To investigate the possible reversal effects of 1,3-diphenyl-1,3-propanedione (DPPD) for cocaine-induced content changes of neurotransmitters of brain in mice.METHODS: In this study, 36 healthy ICR male mice were randomly divided into control group, cocaine group, three DPPD pretreatment
PMID 27318897

Trypanosome Lytic Factor-1 Initiates Oxidation-stimulated Osmotic Lysis of Trypanosoma brucei brucei.

Greene AS1, Hajduk SL2.
The Journal of biological chemistry.J Biol Chem.2016 Feb 5;291(6):3063-75. doi: 10.1074/jbc.M115.680371. Epub 2015 Dec 8.
Human innate immunity against the veterinary pathogen Trypanosoma brucei brucei is conferred by trypanosome lytic factors (TLFs), against which human-infective T. brucei gambiense and T. brucei rhodesiense have evolved resistance. TLF-1 is a subclass of high density lipoprotein particles defined by
PMID 26645690

4-Amino-2-chlorophenol: Comparative in vitro nephrotoxicity and mechanisms of bioactivation.

Rankin GO1, Sweeney A2, Racine C2, Ferguson T2, Preston D2, Anestis DK2.
Chemico-biological interactions.Chem Biol Interact.2014 Oct 5;222:126-32. doi: 10.1016/j.cbi.2014.10.001. Epub 2014 Oct 19.
Chlorinated anilines are nephrotoxicants both in vivo and in vitro. The mechanism of chloroaniline nephrotoxicity may occur via more than one mechanism, but aminochlorophenol metabolites appear to contribute to the adverse in vivo effects. The purpose of this study was to compare the nephrotoxic pot
PMID 25446496

Japanese Journal

Repressive processing of antihypertensive peptides, Val-Pro-Pro and Ile-Pro-Pro, in Lactobacillus helveticus fermented milk by added peptides(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)

Wakai Taketo,Yamaguchi Naoya,Hatanaka Misaki [他],Nakamura Yasunori,Yamamoto Naoyuki
Journal of bioscience and bioengineering 114(2), 133-137, 2012-08
… By DNA microarray analysis it was found that prtH2 corresponding to the cell wall-associated proteinase gene, most of the endopeptidase genes such as pepE, pep0l, pep02 and pep03, most of the oligopeptide transporter genes, such as dppA2, dppB, dppC, dppD and dppF, most likely involved in the processing of VPP and IPP were down-regulated. …
NAID 110009495417

Kawai Yoshiko,Satoh Tomohiko,Hibi Daisuke [他],OHNO Yukihiro,KOHDA Yuka,MIURA Katsuyuki,GEMBA Munekazu
Journal of pharmacological sciences 111(4), 433-439, 2009-12-20
… We examined the effect of an antioxidant, N,N'-diphenyl-1,4-phenylenediamine (DPPD), on development of interstitial fibrosis induced by cisplatin. … Administration of DPPD, which was started at 3 days after cisplatin treatment, significantly inhibited the increase in renal type III collagen contents and the expansion of the interstitial fibrosis area without affecting enzymuria and increased BUN. …
NAID 10026154860

Relationship of Intracellular Calcium and Oxygen Radicals to Cisplatin-Related Renal Cell Injury

Kawai Yoshiko,Nakao Takafumi,Kunimura Naoshi [他],KOHDA Yuka,GEMBA Munekazu
Journal of pharmacological sciences 100(1), 65-72, 2006-01-20
… DPPD (N,N'-diphenyl-p-phenylenediamine), an antioxidant, inhibited a cisplatin-related increase in active oxygen production and cell injury but did not inhibit an early increase in the [Ca2+]i level. …
NAID 10018241164