English Journal

Systemic Sclerosis Sera Impair Angiogenic Performance of Dermal Microvascular Endothelial Cells: Therapeutic Implications of Cyclophosphamide.

Borghini A1, Manetti M2, Nacci F3, Bellando-Randone S3, Guiducci S3, Matucci-Cerinic M3, Ibba-Manneschi L2, Weber E1.
PloS one.PLoS One.2015 Jun 15;10(6):e0130166. doi: 10.1371/journal.pone.0130166. eCollection 2015.
In systemic sclerosis (SSc), dermal capillaries are progressively lost with consequent chronic tissue hypoxia insufficiently compensated by angiogenesis. Clinical studies reported that intravenous cyclophosphamide (CYC) may improve SSc-related peripheral microvascular damage. Recently, we showed tha
PMID 26076019

KSHV regulation of fibulin-2 in Kaposi's sarcoma: implications for tumorigenesis.

Alcendor DJ1, Knobel S, Desai P, Zhu WQ, Hayward GS.
The American journal of pathology.Am J Pathol.2011 Sep;179(3):1443-54. doi: 10.1016/j.ajpath.2011.05.024. Epub 2011 Jul 7.
Kaposi's sarcoma is an angioproliferative tumor caused by Kaposi's sarcoma-associated herpesvirus (KSHV) infection of vascular endothelial cells. Fibulins, proteins that associate with extracellular matrix (ECM) proteins, may have both tumor-suppressive and oncogenic activities. We found that the ex
PMID 21741351

Effect of hyperglycemia and neuropeptides on interleukin-8 expression and angiogenesis in dermal microvascular endothelial cells.

Jain M1, LoGerfo FW, Guthrie P, Pradhan L.
Journal of vascular surgery.J Vasc Surg.2011 Jun;53(6):1654-60.e2. doi: 10.1016/j.jvs.2011.02.019.
BACKGROUND: Impaired wound healing is a major complication associated with diabetes, involving a dysregulation and impairments in the inflammatory and angiogenic phases of wound healing. Here, we examine the effects of the neuropeptides substance P (SP) and neuropeptide Y (NPY) on dermal microvascul
PMID 21609799