関: 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid

PrepTutorEJDIC

Department of the Interior 内務省 / drill instructor 教練係下士官 / discomfort index

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/18 22:33:38」(JST)

wiki ja

4,4'-ジイソチオシアノ-2,2'-スチルベンジスルホン酸(4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, DIDS)は、アニオン交換阻害剤の一つ^[1]。例えば、塩化物イオン-炭酸水素イオン輸送体（バンド3）のようなアンチポートに用いられる^[2]。DIDSはバンド3の外側から結合し同様の阻害剤であるDEPCは内側から結合するが、DIDSが結合したときDEPCは結合せずその逆も成り立つ^[3]。

出典

^ Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), “Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS”, Journal of Membrane Biology 92 (3): 195, doi:10.1007/BF01869388, PMID 3783658
^ Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), “Bicarbonate/Chloride Exchange Regulates Intracellular pH of Embryos but Not Oocytes of the Hamster”, Biology of Reproduction 61 (2): 452–457, doi:10.1095/biolreprod61.2.452, PMID 10411526
^ “赤血球の代謝センサー「バンド3」の構造を解明”. 理化学研究所 (2010年1月22日). 2013年6月18日閲覧。

この項目は、化学に関連した書きかけの項目です。この項目を加筆・訂正などしてくださる協力者を求めています（プロジェクト:化学／Portal:化学）。

wiki en

[Wiki en表示]

4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid (DIDS) is an anion exchange inhibitor,^[1] blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger.^[2]

References

^ Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), "Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS", Journal of Membrane Biology 92 (3): 195, doi:10.1007/BF01869388, PMID 3783658
^ Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), "Bicarbonate/Chloride Exchange Regulates Intracellular pH of Embryos but Not Oocytes of the Hamster", Biology of Reproduction 61 (2): 452–457, doi:10.1095/biolreprod61.2.452, PMID 10411526

This article about an organic compound is a stub. You can help Wikipedia by expanding it.

English Journal

Characterization of an outward rectifying chloride current of Xenopus tropicalis oocytes.

Ochoa-de la Paz LD, Espino-Saldaña AE, Arellano-Ostoa R, Reyes JP, Miledi R, Martinez-Torres A.SourceDepartamento de Neurobiología Celular y Molecular, Laboratorio de Neurobiología Molecular y Celular, Instituto de Neurobiología, Campus UNAM Juriquilla, Querétaro, Qro. CP 76230, Mexico; Departamento de Investigación Biomédica, Facultad de Medicina UAQ, Qro. CP 76170, Mexico.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Aug;1828(8):1743-53. doi: 10.1016/j.bbamem.2013.03.013. Epub 2013 Mar 21.
Here, we describe an outward rectifying current in Xenopus tropicalis oocytes that we have called xtClC-or. The current has two components; the major component is voltage activated and independent of intracellular or extracellular Ca(2+), whereas the second is a smaller component that is Ca(2+) depe
PMID 23524227

Dissecting the molecular mechanism by which NH2htau and Aβ1-42 peptides impair mitochondrial ANT-1 in Alzheimer disease.

Bobba A, Amadoro G, Petragallo VA, Calissano P, Atlante A.SourceInstitute of Biomembranes and Bioenergetics, CNR, Bari, Italy.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Jul;1827(7):848-60. doi: 10.1016/j.bbabio.2013.04.001. Epub 2013 Apr 11.
To find out whether and how the adenine nucleotide translocator-1 (ANT-1) inhibition due to NH2htau and Aβ1-42 is due to an interplay between these two Alzheimer's peptides, ROS and ANT-1 thiols, use was made of mersalyl, a reversible alkylating agent of thiol groups that are oriented toward the ex
PMID 23583906

NHE1 Is the Sodium-Hydrogen Exchanger Active in Acute Intracellular pH Regulation in Preimplantation Mouse Embryos.

Siyanov V, Baltz JM.SourceOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Biology of reproduction.Biol Reprod.2013 Jun 20;88(6):157. doi: 10.1095/biolreprod.113.109033. Print 2013.
Sodium-hydrogen exchangers (NHE) of the Slc9 gene family are the major regulators of intracellular pH against acidosis in mammalian cells. Of five plasma membrane NHE isoforms, mouse oocytes and preimplantation embryos express mRNAs encoding NHE1 (SLC9A1), NHE3 (SLC9A3), and NHE4 (SLC9A4), with high
PMID 23677982

Japanese Journal

Appearance of Segmental Discrepancy of Anion Transport in Rat Distal Colon(Molecular and Cell Biology)

Xue Hong,Tian Yue Min,Yan Ming [他],YANG Ning,CHEN Xin,XING Ying,ZHU Jin Xia
Biological & pharmaceutical bulletin 30(8), 1407-1411, 2007-08-01
… Pretreatment with luminal amiloride (10 μM), an inhibitor of ENaC, and serosal 4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid (DIDS) (200 μM), an inhibitor of NBC, significantly inhibited the forskolin-induced I_<sc> …
NAID 110006366791

Membrane Stretch-Induced Activation of a TRPM4-Like Nonselective Cation Channel in Cerebral Artery Myocytes

Morita Hiromitsu,Honda Akira,Inoue Ryuji [他],ITO Yushi,ABE Kihachiro,NELSON Mark T.,BRAYDEN Joseph E.
Journal of pharmacological sciences 103(4), 417-426, 2007-04-20
… These channels were permeable to Na+ and Cs+ and inhibited by Gd3+ (30 μM) and DIDS (100 μM). …
NAID 10024313668

Protein Kinase A Catalytic Subunit Alters Cardiac Mitochondrial Redox State and Membrane Potential Via the Formation of Reactive Oxygen Species

Nagasaka Shiro,Katoh Hideki,Niu Chunfeng,Matsui Saori,Urushida Tsuyoshi,Satoh Hiroshi,Watanabe Yasuhide,Hayashi Hideharu
2007-02-20
… PKAcat-induced ΔΨm depolarization was inhibited by an inhibitor of the inner membrane anion channel (IMAC), 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS: 1μmol/L) but not by an inhibitor of mitochondrial permeability transition pore (mPTP), cyclosporine A (100 nmol/L).Conclusions PKAcat alters FAD and ΔΨm via mitochodrial ROS generation, and PKAcat-induced ΔΨm depolarization was not caused by mPTP but rather by DIDS-sensitive mechanisms, which could be caused by opening of the IMAC. …
NAID 120005314191

Related Pictures

★リンクテーブル★

リンク元	「ジイソチオシアノスチルベンジスルホン酸」「4,4'-diisothiocyanostilbene-2,2'-disulfonic acid」
関連記事	「DI」

「ジイソチオシアノスチルベンジスルホン酸」

DIDS
Names
	IUPAC name 5-Isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzene-1-sulfonic acid
	Other names 5-Isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid
Identifiers
Abbreviations	DIDS
Beilstein Reference	6543839
CAS Registry Number	53005-05-3 (E)
ChEBI	CHEBI:36511
ChemSpider	37094 ; 4445228 (E) ; 7827632 (Z)
	InChI InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24); Key: YSCNMFDFYJUPEF-UHFFFAOYSA-N ;
Jmol-3D images	Image
KEGG	C11591
MeSH	4,4'-Diisothiocyanostilbene-2,2'-disulfonic+acid
PubChem	40600; 5281951 (E); 9548709 (Z)
	SMILES OS(=O)(=O)C1=C(C=CC2=C(C=C(C=C2)N=C=S)S(O)(=O)=O)C=CC(=C1)N=C=S ;
Properties
Molecular formula	C16H10N2O6S4
Molar mass	454.52 g·mol−1
Melting point	400 °C (752 °F; 673 K)
log P	4.72
Acidity (pKa)	-3.21, -1.428, -0.37, 0.23
Basicity (pKb)	13.77, 14.37, 15.425, 17.21
	Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	Infobox references

DIDS
	IUPAC名 5-Isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzene-1-sulfonic acid
	別称 5-Isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid
識別情報
略称	DIDS
CAS登録番号	53005-05-3 (E)
PubChem	40600, 5281951 (E), 9548709 (Z)
ChemSpider	37094 , 4445228 (E) , 7827632 (Z)
KEGG	C11591
MeSH	4,4'-Diisothiocyanostilbene-2,2'-disulfonic+acid
ChEBI	CHEBI:36511
バイルシュタイン	6543839
	SMILES OS(=O)(=O)C1=C(C=CC2=C(C=C(C=C2)N=C=S)S(O)(=O)=O)C=CC(=C1)N=C=S;
	InChI InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24); Key: YSCNMFDFYJUPEF-UHFFFAOYSA-N;
特性
化学式	C16H10N2O6S4
モル質量	454.52 g mol−1
精密質量	453.942168822 g mol-1
融点	400 °C, 673 K, 752 °F
log POW	4.72
酸解離定数 pKa	-3.21, -1.428, -0.37, 0.23
塩基解離定数 pKb	13.77, 14.37, 15.425, 17.21
	特記なき場合、データは常温 (25 °C)・常圧 (100 kPa) におけるものである。

　　[★]

英

4

4,4'-diisothiocyanostilbene-2,2'-disulfonic acid、DIDS

関: 4,4'-ジイソチオシアノスチルベン-2,2'-ジスルホン酸

「4,4'-diisothiocyanostilbene-2,2'-disulfonic acid」

　　[★]

4、ジイソチオシアノスチルベンジスルホン酸

関: DIDS

「DI」

　　[★]

[Jessen1986-1] Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), “Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS”, Journal of Membrane Biology 92 (3): 195, doi:10.1007/BF01869388, PMID 3783658

[Lane1999-2] Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), “Bicarbonate/Chloride Exchange Regulates Intracellular pH of Embryos but Not Oocytes of the Hamster”, Biology of Reproduction 61 (2): 452–457, doi:10.1095/biolreprod61.2.452, PMID 10411526

[3] “赤血球の代謝センサー「バンド3」の構造を解明”. 理化学研究所 (2010年1月22日). 2013年6月18日閲覧。

[Jessen1986-1] Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), "Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS", Journal of Membrane Biology 92 (3): 195, doi:10.1007/BF01869388, PMID 3783658

[Lane1999-2] Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), "Bicarbonate/Chloride Exchange Regulates Intracellular pH of Embryos but Not Oocytes of the Hamster", Biology of Reproduction 61 (2): 452–457, doi:10.1095/biolreprod61.2.452, PMID 10411526

匿名

検索

案内

案内

DIDS