English Journal

in vitro and in vivo anti-hepatitis B virus activities of the lignan niranthin isolated from Phyllanthus niruri L.

Liu S1, Wei W2, Shi K3, Cao X1, Zhou M1, Liu Z4.
Journal of ethnopharmacology.J Ethnopharmacol.2014 Jul 4. pii: S0378-8741(14)00433-4. doi: 10.1016/j.jep.2014.05.064. [Epub ahead of print]
ETHNOPHARMACOLOGICAL RELEVANCE: Niranthin is a lignan isolated from Phyllanthus niruri L. This plant has long been used in folk medicine for liver protection and antihepatitis B in many Asian countries. This study was designed to evaluate the anti-hepatitis B virus activity of niranthin using HepG2.
PMID 25009077

SGHBV Envelope and Capsid Proteins Independently Contribute to its Ability to Package Capsids Containing ssDNA in Virions.

Greco N1, Hayes MH2, Loeb DD3.
Journal of virology.J Virol.2014 Jul 2. pii: JVI.01694-14. [Epub ahead of print]
Hepadnaviruses selectively package capsids containing mature dsDNA genomes in virions. Snow goose hepatitis B virus (SGHBV) is the only known hepadnavirus that packages capsids containing ssDNA in virions. We found that cells replicating SGHBV produce virions containing ssDNA as efficiently as virio
PMID 24991016

Evaluation of Hepatocyteprotective and Anti-hepatitis B Virus Properties of Cichoric Acid from Cichorium intybus Leaves in Cell Culture.

Zhang HL1, Dai LH, Wu YH, Yu XP, Zhang YY, Guan RF, Liu T, Zhao J.
Biological & pharmaceutical bulletin.Biol Pharm Bull.2014 Jul 1;37(7):1214-20. Epub 2014 Apr 24.
Hepatitis B is the most common serious liver infection in the world. To date, there is still no complete cure for chronic hepatitis B. Natural caffeic acid analogues possess prominent antiviral activity, especially anti-hepatitis B virus (HBV) and anti-human immunodeficiency virus effects. Cichoric
PMID 24759764

Japanese Journal

Anti-hepatitis B Virus Activity of α-DDB-FNCG, a Novel Nucleoside-Biphenyldicarboxylate Compound In Vitro and In Vivo

Yang Qinghua,Zhao Xuejie,Yu Wenquan [他],He Wu,Fang Xianzhen,Zang Limin,Wan Na,Wang Qingduan,Zheng Liyun,Chang Junbiao
Journal of Pharmacological Sciences 126(3), 208-215, 2014
… In DHBV-infected ducks, the viral DNA levels in serum and liver were determined by FQ-PCR. … Furthermore, this codrug could also significantly inhibit the viral DNA replication and reduce the ALT and AST levels in both serum and liver of DHBV-infected ducks, with improved hepatocellular architecture in drug-treated ducks. …
NAID 130004704279

Evaluation of Hepatocyteprotective and Anti-hepatitis B Virus Properties of Cichoric Acid from Cichorium intybus Leaves in Cell Culture

Zhang Hong-Li,Dai Ling-Hao,Wu Yi-Hang,Yu Xiao-Ping,Zhang Yong-Yong,Guan Rong-Fa,Liu Tao,Zhao Jun
Biological and Pharmaceutical Bulletin 37(7), 1214-1220, 2014
… In the study, the anti-hepatitis B property of cichoric acid was evaluated by the D-galactosamine (D-GalN)-induced normal human HL-7702 hepatocyte injury model, the duck hepatitis B virus (DHBV)-infected duck fetal hepatocytes and the HBV-transfected cell line HepG2.2.15 cells, respectively. … Moreover, cichoric acid at 1–100 µg/mL inhibited markedly DHBV DNA replication in infected duck fetal hepatocytes. …
NAID 130003390997

Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus

Chowdhury Sajeda,Kitamura Kouichi,Simadu Miyuki,Koura Miki,Muramatsu Masamichi
FEBS Letters 587(18), 3148-3142, 2013-09-17
… Covalently closed circular DNA (cccDNA) forms a template for the replication of hepatitis B virus (HBV) and duck HBV (DHBV). … Here we demonstrated that overexpression of chicken AID caused hypermutation and reduction of DHBV cccDNA levels. …
NAID 120005327231