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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/09/25 14:16:01」(JST)

English Journal

Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition.

Olajide OA, Bhatia HS, de Oliveira AC, Wright CW, Fiebich BL.SourcePharmacy and Pharmaceutical Sciences, School of Applied Sciences, University of Huddersfield, Huddersfield, West Yorkshire HD1 3DH, United Kingdom. o.a.olajide@hud.ac.uk
European journal of medicinal chemistry.Eur J Med Chem.2013 May;63:333-9. doi: 10.1016/j.ejmech.2013.02.004. Epub 2013 Feb 19.
Cryptolepis sanguinolenta and its bioactive alkaloid, cryptolepine have shown anti-inflammatory activity. However, the underlying mechanism of anti-inflammatory action in neuronal cells has not been investigated. In the present study we evaluated an extract of C. sanguinolenta (CSE) and cryptolepin
PMID 23507189

The G-quadruplex ligand, SYUIQ-FM05, targets proto-oncogene c-kit transcription and induces apoptosis in K562 cells.

Shen FH, Jin J, Li J, Wang Y, Zhu SH, Lu YJ, Ou TM, Huang ZS, Huang M, Huang ZY.SourceCenter of Preclinical Screening and Evaluation on New Drug, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China.
Pharmaceutical biology.Pharm Biol.2013 Apr;51(4):447-54. doi: 10.3109/13880209.2012.738424. Epub 2013 Jan 30.
CONTEXT: N'-(7-Fluoro-5-N-methyl-10H-indolo[3,2-b]quinolin-5-ium)-N,N-dimethylpropane-1,3-diamine iodide (SYUIQ-FM05) is a semi-synthetic derivative of cryptolepine which is from Cryptolepis sanguinolenta (Lindl.) Schlechter (Periplocaeae). This ligand inhibits telomerase activity by stabilizing the
PMID 23363047

Olajide OA, Bhatia HS, de Oliveira AC, Wright CW, Fiebich BL.SourceSchool of Applied Sciences, University of Huddersfield, Huddersfield, West Yorkshire HD1 3DH, UK ; Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, 79104 Freiburg, Germany.
Evidence-based complementary and alternative medicine : eCAM.Evid Based Complement Alternat Med.2013;2013:459723. doi: 10.1155/2013/459723. Epub 2013 May 8.
Cryptolepine, an indoloquinoline alkaloid in Cryptolepis sanguinolenta, has anti-inflammatory property. In this study, we aimed to evaluate the effects of cryptolepine on lipopolysaccharide (LPS)- induced neuroinflammation in rat microglia and its potential mechanisms. Microglial activation was indu
PMID 23737832