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Coccidioides is a genus of dimorphic ascomycete, cause of Coccidioidomycosis, also known as San Joaquin Valley Fever, an infectious fungal disease largely confined to the Western Hemisphere and endemic in the Southwestern United States.^[1] The host acquires the disease via respiratory inhalation of spores disseminated in their natural habitat. The causative agents of coccidioidomycosis are Coccidioides immitis and Coccidioides posadasii. Both C. immitas and C. posadasii are non-distinguishable during laboratory testing and commonly referred in literature as Coccidioides.^[2]

Clinical presentation

Coccidioidomycosis which is caused by Coccidioides pathogenes is amazingly diverse in terms of its scope of clinical presentation, as well as clinical severity. 60% of Coccidioides infections as determined by serologic conversion are asymptomatic. The most common clinical syndrome in the other 40% of infected patients is an acute respiratory illness characterized by fever, cough, and pleuritic pain. Skin manifestations, such as erythema nodosum, are also common with Coccidioides infection. Coccidioides infection can cause a severe and difficult to-treat meningitis in AIDS and other immunocompromised patients, and occasionally in immunocompetent hosts. Infection can sometimes cause acute respiratory distress syndrome and fatal multilobar pneumonia. The risk of symptomatic infection increases with age.

Epidemiology

The primary Coccidioidomycosis endemic areas are located in Southern California and Southern Arizona, and also in northern Mexico, in the states of Sonora, Nuevo León, Coahuila and Baja California, where it resides in soil.^[3] Both Coccidioides immitis and Coccidioides posadasii were viewed as desert saprophytes, however, recent genomic research revealed that Coccidioides evolved interacting with their animal hosts.^[4]

References

^ "Coccidioidomycosis (Valley Fever)". Centers for Disease Control and Prevention (CDC). Retrieved 11 July 2013.
^ Fauci, Anthony S. Harrison's Principles of Internal Medicine. New York: McGraw-Hill Medical, 2008.
^ Baptista-Rosas, Riquelme M., Hinojosa A. Ecological niche modeling of Coccidioides spp. in Western North American deserts. Annals of the New York Academy of Sciences, 2007, Vol. 1111, pp. 35-46.
^ Sharpton, T. J., Stajich, J. E., Rounsley, S. D., et al. (October 2009). "Comparative Genomic Analyses of the Human Fungal Pathogens Coccidioides and Their Relatives". Genome Research 19 (10): 1722–31.

External links

Coccidioides sp.
National Center for Biotechnology Information: Coccidioides

This Eurotiomycetes-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 原発性コクシジオイデス感染 primary coccidioidal infection
2. コクシジオイデス症の臨床検査診断 laboratory diagnosis of coccidioidomycosis
3. 肺外コクシジオイデス症の臨床症状および治療 manifestations and treatment of extrapulmonary coccidioidomycosis
4. 成人における市中肺炎の疫学、病因、および微生物学 epidemiology pathogenesis and microbiology of community acquired pneumonia in adults
5. コクシジオイデス性髄膜炎 coccidioidal meningitis

English Journal

Low Utility of Pediatric Isolator Blood Culture System for Detection of Fungemia in Children: a 10-Year Review.

Campigotto A1, Richardson SE2, Sebert M3, McElvania TeKippe E4, Chakravarty A5, Doern CD6.
Journal of clinical microbiology.J Clin Microbiol.2016 Sep;54(9):2284-7. doi: 10.1128/JCM.00578-16. Epub 2016 Jun 15.
The use of the Wampole Isolator 1.5-ml pediatric blood culture tube for the detection of fungemia in children was assessed by a 10-year retrospective review at two pediatric hospitals, The Hospital for Sick Children in Toronto, Canada, and the Children's Medical Center of Dallas, Texas. Over this pe
PMID 27307462

PET/CT: First-Line Examination to Assess Disease Extent of Disseminated Coccidioidomycosis.

Foerter J1, Sundell J2, Vroman P2.
Journal of nuclear medicine technology.J Nucl Med Technol.2016 Sep;44(3):212-3. doi: 10.2967/jnmt.115.170449. Epub 2016 Apr 21.
Coccidioidomycosis is an infection caused by inhalation of the Coccidioides fungus. Most infections remain subclinical or are confined to the pulmonary system. Disseminated disease is rare. Traditionally, a combination of imaging modalities has been used to determine disease extent. We suggest (18)F
PMID 27102664

Synthesis and in vitro antifungal activity of isoniazid-derived hydrazones against Coccidioides posadasii.

Cordeiro Rde A1, de Melo CV2, Marques FJ2, Serpa R2, Evangelista AJ2, Caetano EP2, Mafezoli J3, de Oliveira Mda C3, da Silva MR3, Bandeira Tde J4, Moreira JL2, Brilhante RS2, Rocha MF5, Sidrim JJ2.
Microbial pathogenesis.Microb Pathog.2016 Sep;98:1-5. doi: 10.1016/j.micpath.2016.06.022. Epub 2016 Jun 19.
Coccidioidomycosis is a potentially severe infection caused by dimorphic fungi Coccidioides immitis and Coccidioides posadasii. Although guidelines are well established, refractory disease is a matter of concern in the clinical management of coccidioidomycosis. In the present study three isoniazid-d
PMID 27334293

Japanese Journal

慢性肺コクシジオイデス症(コクシジオイドーマ)の1切除例

尾崎良智,井上修平,藤田琢也,大内政嗣,高萩亮宏
日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery 25(7), 756-760, 2011-11-15
… があり，英語教師として来日し，翌年の検診で胸部異常陰影を指摘された．自覚症状はなく，胸部CTで右肺下葉に2cm大の円形孤立性結節影を認めた．胸腔鏡下右肺部分切除を施行され，切除標本より<I>Coccidioides immitis</I>を検出し，慢性肺コクシジオイデス症（コクシジオイドーマ）と診断された．本症の我が国での報告数は増加傾向にあるが認知度はいまだ低く，流行地への訪問歴，滞在歴のある患者の診療に …
NAID 10029652514

P-010 輸入真菌症原因菌Coccidioides immitisおよびC.posadasiiのチトクロームb遺伝子解析(分類・同定・系統・環境,ポスター討論,一般演題,医真菌学のコペルニクス的転回を目指して)

各務清美,王麗,スワラジットビスワス,横山耕治
日本医真菌学会総会プログラム抄録集 51(Supplement_1), 64, 2010-09-17
NAID 110007767235

今月の表紙帰ってきた真菌症(1)輸入真菌--Coccidioides immitisとHistoplasma capsulatum

亀井克彦
臨床検査 53(1), 4-6, 2009-01-00
NAID 40016441032

「coccidioidal」

Coccidioides
	C. immitis
Scientific classification
Kingdom:	Fungi
Phylum:	Ascomycota
Class:	Eurotiomycetes
Order:	Onygenales
Family:	Onygenaceae
Genus:	Coccidioides

　　[★]

コクシジウム性の、コクシジウムの、コクシジオイデスの

関: coccidian、Coccidioides

「コクシジオイデス属」

　　[★]

ラ: Coccidioides
同: コクシジオイデス、Coccidioides属

Coccidioides immitis

「Coccidioides immitis」

　　[★]

ラ: Coccidioides immitis
同: コクシジオイデス・イミチス

感染症

coccidioidomycosis coccidioides infection

「Coccidioides infection」

　　[★] coccidioides infection

関: Coccidioidomy- cosis

「Coccidioides属」

　　[★] コクシジオイデス属

[1] "Coccidioidomycosis (Valley Fever)". Centers for Disease Control and Prevention (CDC). Retrieved 11 July 2013.

[2] Fauci, Anthony S. Harrison's Principles of Internal Medicine. New York: McGraw-Hill Medical, 2008.

[3] Baptista-Rosas, Riquelme M., Hinojosa A. Ecological niche modeling of Coccidioides spp. in Western North American deserts. Annals of the New York Academy of Sciences, 2007, Vol. 1111, pp. 35-46.

[4] Sharpton, T. J., Stajich, J. E., Rounsley, S. D., et al. (October 2009). "Comparative Genomic Analyses of the Human Fungal Pathogens Coccidioides and Their Relatives". Genome Research 19 (10): 1722–31.

リンク元	「coccidioidal」「コクシジオイデス属」
拡張検索	「Coccidioides immitis」「Coccidioides infection」「Coccidioides属」

匿名

検索

案内

案内

Coccidioides