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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/15 11:35:11」(JST)

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Cefotetan is an injectable antibiotic of the cephamycin type for prophylaxis and treatment of bacterial infections. It is often grouped together with second-generation cephalosporins and has a similar antibacterial spectrum, but with additional anti-anaerobe coverage.

Cefotetan was developed by Yamanouchi. It is marketed outside Japan by AstraZeneca with the brand names Apatef and Cefotan.

Adverse effects[edit]

The chemical structure of cefotetan, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.^[1]

Spectrum of bacterial susceptibility[edit]

Cefotetan has a broad spectrum of activity and has been used to treat bacterial infections of the bone, skin, urinary tract, and lower respiratory tract. Notable species include Bacteroides, Streptococcus, and Escherichia. The following represents MIC susceptibility data for a few medically significant bacteria.

Escherichia coli: 0.06 µg/mL
Bacteroides fragilis: ≤0.06 µg/mL - 512 µg/mL
Clostridium perfringins: 1 µg/mL - 4 µg/mL

^[2]

References[edit]

^ Stork CM (2006). "Antibiotics, antifungals, and antivirals". In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA (eds.). Goldfrank's toxicologic emergencies. New York: McGraw-Hill. p. 847. ISBN 0-07-143763-0. Retrieved 2009-07-03.
^ http://www.toku-e.com/Assets/MIC/Cefotetan.pdf

External links[edit]

Cefotan official web site run by AstraZeneca US
Cefotetan entry in RxList

English Journal

The identification, typing, and antimicrobial susceptibility of Pseudomonas aeruginosa isolated from mink with hemorrhagic pneumonia.

Qi J1, Li L2, Du Y1, Wang S3, Wang J1, Luo Y2, Che J4, Lu J4, Liu H5, Hu G5, Li J6, Gong Y6, Wang G7, Hu M8, Shiganyan8, Liu Y9.
Veterinary microbiology.Vet Microbiol.2014 Jun 4;170(3-4):456-61. doi: 10.1016/j.vetmic.2014.02.025. Epub 2014 Feb 25.
The biological characteristics and molecular epidemiology of Pseudomonas aeruginosa associated with mink hemorrhagic pneumonia from Shandong province of eastern China were determined in this study. From 2010 to 2011, 30 mink P. aeruginosa isolates were identified from lung, fecal and feed samples of
PMID 24629901

The changes of PCR ribotype and antimicrobial resistance of Clostridium difficile in a tertiary care hospital in Korea over 10 years.

Lee JH1, Lee Y, Lee K, Riley TV, Kim H.
Journal of medical microbiology.J Med Microbiol.2014 Apr 2. doi: 10.1099/jmm.0.072082-0. [Epub ahead of print]
The aims of this study were to investigate any change in PCR ribotypes and to determine the antimicrobial resistance of common PCR ribotypes over a 10-year period in a tertiary care hospital. We conducted PCR ribotyping, antimicrobial susceptibility testing, and DNA gyrase sequencing to identify cha
PMID 24696516

Microbiological Spectrum and Antibiotic Sensitivity in Endophthalmitis: A 25-Year Review.

Gentile RC1, Shukla S2, Shah M3, Ritterband DC2, Engelbert M4, Davis A5, Hu DN3.
Ophthalmology.Ophthalmology.2014 Apr 2. pii: S0161-6420(14)00105-5. doi: 10.1016/j.ophtha.2014.02.001. [Epub ahead of print]
PURPOSE: To identify the spectrum and susceptibility pattern of pathogens responsible for culture-positive endophthalmitis referred to a single institution and investigate possible trends in both pathogens and antibiotic sensitivities over the past 25 years.DESIGN: A retrospective, laboratory-based
PMID 24702755

Related Pictures

10 GM $Cefotan Carl: \x26quot;I learned about$ Chemical formula: $Cefotan Carl: \x26quot;I learned about$ Cefotan classification cefotetan ,Cefotan ,Ceftotan ,Cefotetanum

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リンク元

「セフォテタン」

Cefotetan
Systematic (IUPAC) name
	(7S)-7-{[4-(1-amino-3-hydroxy-1,3-dioxopropan-2-ylidene); 1,3-dithietane-2-carbonyl]amino}-7-methoxy-; 3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-; 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
AHFS/Drugs.com	Consumer Drug Information
Legal status	?
Identifiers
CAS number	69712-56-7
ATC code	J01DC05
PubChem	CID 53025
DrugBank	DB01330
ChemSpider	47904
UNII	48SPP0PA9Q
KEGG	D00260
ChEBI	CHEBI:3499
ChEMBL	CHEMBL474579
Chemical data
Formula	C17H17N7O8S4
Mol. mass	575.623 g/mol
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@]2(OC)NC(=O)C3S/C(S3)=C(/C(=O)N)C(=O)O)CSc4nnnn4C)C(=O)O;
	InChI InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1 ; Key:SRZNHPXWXCNNDU-IXOPCIAXSA-N ;
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英: cefotetan
化: セフォテタンナトリウム cefotetan sodium
商: Cefotan

[Goldfrank-1] Stork CM (2006). "Antibiotics, antifungals, and antivirals". In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA (eds.). Goldfrank's toxicologic emergencies. New York: McGraw-Hill. p. 847. ISBN 0-07-143763-0. Retrieved 2009-07-03.

[2] ttp://www.toku-e.com/Assets/MIC/Cefotetan.pdf

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Cefotan