CYP8B1タンパク質

関: 12-alpha-hydroxylase、12alpha-hydroxylase、steroid 12-alpha-hydroxylase

steroid 12alpha-hydroxylase

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/01/19 00:33:50」(JST)

wiki en

CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) also known as sterol 12-alpha-hydroxylase is a protein which in humans is encoded by the CYP8B1 gene.^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

CYP8B1 is an endoplasmic reticulum membrane protein and catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of the two primary bile acids, cholic acid and chenodeoxycholic acid, both of which are secreted in the bile. In the intestine these bile acids affect the solubility of cholesterol and other lipids, promoting their absorption.

CYP8B1 is unique among the cytochrome P450 genes in that it is intronless.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180432 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050445 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Gåfvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Björkhem I, Eggertsen G (March 1999). "Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns". Genomics. 56 (2): 184–96. doi:10.1006/geno.1998.5606. PMID 10051404.
^ "Entrez Gene: CYP8B1".

English Journal

Cyp8b1 ablation prevents western diet-induced weight gain and hepatic steatosis due to impaired fat absorption.

Bertaggia E1, Jensen KK2, Castro-Perez J2, Xu Y1, Di Paolo G1, Chan RB1, Wang L2, Haeusler RA3.
American journal of physiology. Endocrinology and metabolism.Am J Physiol Endocrinol Metab.2017 Apr 4:ajpendo.00409.2016. doi: 10.1152/ajpendo.00409.2016. [Epub ahead of print]
PMID 28377401

Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes.

Kang L1, Si L2, Rao J1, Li D1, Wu Y1, Wu S3, Wu M4, He S1, Zhu W1, Wu Y1, Xu J1, Li G2, Huang J5.
Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2017 Apr;40:313-323. doi: 10.1016/j.tiv.2017.01.022. Epub 2017 Feb 2.
PMID 28161596

Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration.

Miura T1, Tachikawa M2, Ohtsuka H3, Fukase K3, Nakayama S3, Sakata N3, Motoi F3, Naitoh T3, Katayose Y4, Uchida Y2, Ohtsuki S5, Terasaki T6, Unno M3.
Journal of pharmaceutical sciences.J Pharm Sci.2017 Feb 27. pii: S0022-3549(17)30127-2. doi: 10.1016/j.xphs.2017.02.018. [Epub ahead of print]
PMID 28249806

Japanese Journal

Dioxin-Produced Alteration in the Profiles of Fecal and Urinary Metabolomes: A Change in Bile Acids and Its Relevance to Toxicity

Biological and Pharmaceutical Bulletin 38(10), 1484-1495, 2015
NAID 130005101584

Effects of ginsenosides on the expression of cytochrome P450s and transporters involved in cholesterol metabolism

Journal of natural medicines 68(2), 395-401, 2014
NAID 40020023332

LRH-1 heterozygous knockout mice are prone to mild obesity

Endocrine Journal 61(5), 471-480, 2014
NAID 130004443971

Related Pictures

Modulation of Bile Acid Metabolism by 1α-Hydroxyvitamin D3 Administration in Mice Physiological and molecular biochemical mechanisms of bile formation Prof Stefano Fiorucci - Nuclear receptors and lipid metabolism on FXR Decreased Bile-Acid Synthesis in Livers of Hepatocyte-Conditional NADPH–Cytochrome Loss of Cyp8b1 Improves Glucose Homeostasis by Increasing GLP-1 | Diabetes CYP8B1 Antibodies: Novus Biologicals JCI - Does loss of bile acid homeostasis make mice melancholy?

★リンクテーブル★

リンク元	「12alpha-hydroxylase」
拡張検索	「CYP8B1タンパク質」

「12alpha-hydroxylase」

CYP8B1
Identifiers
Aliases	CYP8B1, CP8B, CYP12, cytochrome P450 family 8 subfamily B member 1
External IDs	MGI: 1338044 HomoloGene: 3233 GeneCards: CYP8B1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	42,876,165 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	121,916,305 bp
Gene ontology
Molecular function	• monooxygenase activity; • iron ion binding; • oxygen binding; • oxidoreductase activity; • heme binding; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • metal ion binding; • 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity; • sterol 12-alpha-hydroxylase activity;
Cellular component	• integral component of membrane; • organelle membrane; • endoplasmic reticulum membrane; • endoplasmic reticulum; • membrane; • intracellular membrane-bounded organelle;
Biological process	• sterol metabolic process; • bile acid biosynthetic process; • oxidation-reduction process;
	Sources:Amigo / QuickGO
Orthologs
	1582
	13124
	ENSG00000180432
	ENSMUSG00000050445
	Q9UNU6
	O88962
	NM_004391
	NM_010012
	NP_004382
	NP_034142
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

12α水酸化酵素、12αヒドロキシラーゼ

関: 12-alpha-hydroxylase、CYP8B1、steroid 12-alpha-hydroxylase

「CYP8B1タンパク質」

　　[★]

英

(n

CYP8B1

関: ステロイド12α水酸化酵素、12α水酸化酵素

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180432 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050445 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10051404-5] Gåfvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Björkhem I, Eggertsen G (March 1999). "Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns". Genomics. 56 (2): 184–96. doi:10.1006/geno.1998.5606. PMID 10051404.

[entrez-6] "Entrez Gene: CYP8B1".

v t e Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
CYP1	A1 A2 B1
CYP2	A6 A7 A13 B6 C8 C9 C18 C19 D6 E1 F1 J2 R1 S1 U1 W1
CYP3 (CYP3A)	A4 A5 A7 A43
CYP4	A11 A22 B1 F2 F3 F8 F11 F12 F22 V2 X1 Z1
CYP5-20	CYP5 (A1) CYP7 (A1, B1) CYP8 (A1, B1) CYP11 (A1, B1, B2) CYP17 (A1) CYP19 (A1) CYP20 (A1)
CYP21-51	CYP21 (A2) CYP24 (A1) CYP26 (A1, B1, C1) CYP27 (A1, B1, C1) CYP39 (A1) CYP46 (A1) CYP51 (A1)

匿名

検索

案内

案内

CYP8B1