English Journal

Lentinus edodes promotes fat removal in hypercholesterolemic mice.

Yang H, Hwang I, Kim S, Hong EJ, Jeung EB.SourceLaboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
Experimental and therapeutic medicine.Exp Ther Med.2013 Dec;6(6):1409-1413. Epub 2013 Oct 8.
Lentinus (L.) edodes (shiitake mushroom) is used as a traditional medicine in Asia. One of the components of L. edodes, eritadenine (an adenosine analog alkaloid), has been shown to reduce cholesterol levels. The hypocholesterolemic action of eritadenine appears to be achieved through the modificati
PMID 24255670

Modulation of Lipid Metabolism by Deep-Sea Water in Cultured Human Liver (HepG2) Cells.

He S, Hao J, Peng W, Qiu P, Li C, Guan H.SourceKey Laboratory of Marine Drugs, Ministry of Education, Marine Drugs and Food Institute, Ocean University of China, Qingdao, 266003, People's Republic of China.
Marine biotechnology (New York, N.Y.).Mar Biotechnol (NY).2013 Sep 24. [Epub ahead of print]
It has been found that deep-sea water was associated with lower serum lipid in animal model studies. Herein, we investigated whether DSW exerted a hypolipidemic activity and further elucidated how DSW modulated lipid metabolism in HepG2 cells. Preliminary animal studies showed that DSW exhibited pot
PMID 24057172

Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism.

Kerr TA, Matsumoto Y, Matsumoto H, Xie Y, Hirschberger LL, Stipanuk MH, Anakk S, Moore DD, Watanabe M, Kennedy S, Davidson NO.SourceDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri.
Hepatology research : the official journal of the Japan Society of Hepatology.Hepatol Res.2013 Aug 23. doi: 10.1111/hepr.12230. [Epub ahead of print]
AIM: Bile acid synthesis is regulated by nuclear receptors including farnesoid X receptor (FXR) and small heterodimer partner (SHP), and by fibroblast growth factor 15/19 (FGF15/19). We hypothesized that hepatic cysteine sulfinic acid decarboxylase (CSAD) (a key enzyme in taurine synthesis) is regul
PMID 24033844

Japanese Journal

Dioxin-Produced Alteration in the Profiles of Fecal and Urinary Metabolomes: A Change in Bile Acids and Its Relevance to Toxicity

Kakizuka Saki,Takeda Tomoki,Komiya Yukiko,Koba Akihiko,Uchi Hiroshi,Yamamoto Midori,Furue Masutaka,Ishii Yuji,Yamada Hideyuki
Biological and Pharmaceutical Bulletin 38(10), 1484-1495, 2015
… In addition, CYP7A1, a rate-limiting enzyme for bile acid biosynthesis, was attenuated by TCDD treatment, although TCDD induced hepatic CYP8B1, an enzyme essential for cholic acid synthesis. …
NAID 130005101584

Role of Nrf2 in the alteration of cholesterol and bile acid metabolism-related gene expression by dietary cholesterol in high fat-fed mice

Kamisako Toshinori,Tanaka Yuji,Kishino Yoshizumi,Ikeda Takanori,Yamamoto Kazuo,Masuda Shiori,Ogawa Hiroshi
Journal of Clinical Biochemistry and Nutrition 54(2), 90-94, 2014
… High cholesterol diet increased hepatic expression of liver X receptor α target genes related to fatty acid metabolism (FAS, ACC1, SREBP-1c, SCD-1c and CD36), cholesterol transport (Abcg5/abcg8) and bile acid synthesis (Cyp7a1) in wild type mice. …
NAID 130004879357

Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice

Nakahashi Otoki,Yamamoto Hironori,Tanaka Sarasa,Kozai Mina,Takei Yuichiro,Masuda Masashi,Kaneko Ichiro,Taketani Yutaka,Iwano Masayuki,Miyamoto Ken-ichi,Takeda Eiji
Journal of Clinical Biochemistry and Nutrition 54(2), 102-108, 2014
… Furthermore, diurnal variations of plasma triglyceride concentrations and hepatic mRNA expression of the bile acid synthesis enzyme Cyp7a1 as one of Fgf15 negative target genes was influenced by dietary Pi restriction. …
NAID 130004879348

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