CYP17B1タンパク質

関: 25-hydroxyvitamin D3 1-alpha-hydroxylase

25-hydroxyvitamin D3 1alpha-hydroxylase

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/31 03:36:40」(JST)

wiki en

25-Hydroxyvitamin D₃ 1-alpha-hydroxylase (VD3 1A hydroxylase) also known as cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene.^[1]^[2]^[3]

VD3 1A hydroxylase is located in the proximal tubule of the kidney and a variety of other tissues, including skin (keratinocytes), immune cells,^[4] and bone (osteoblasts).^[5] The enzyme catalyzes the hydroxylation of Calcifediol to calcitriol (the bioactive form of Vitamin D):^[6]

calcidiol + NADPH + H⁺ + O₂ calcitriol + NADP⁺ + H₂O

Calcidiol
Calcitriol

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

[[File:

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

|{{{bSize}}}px|alt=Vitamin D Synthesis Pathway edit]]

File:VitaminDSynthesis WP1531.png

Vitamin D Synthesis Pathway edit

^ The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".

References

^ "Entrez Gene: cytochrome P450".
^ Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S (Sep 1997). "25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis". Science 277 (5333): 1827–30. doi:10.1126/science.277.5333.1827. PMID 9295274.
^ Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T (Oct 1997). "Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase". Biochemical and Biophysical Research Communications 239 (2): 527–33. doi:10.1006/bbrc.1997.7508. PMID 9344864.
^ Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC (Mar 2007). "DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27" (PDF). Nature Immunology 8 (3): 285–93. doi:10.1038/ni1433. PMID 17259988.
^ Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ (Oct 2010). "Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption". Endocrinology 151 (10): 4613–25. doi:10.1210/en.2010-0334. PMID 20739402.
^ Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF (Dec 1972). "25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties". The Journal of Biological Chemistry 247 (23): 7528–32. PMID 4404596.

External links

25-Hydroxyvitamin D3 1-alpha-Hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)

Molecular and Cellular Biology portal

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 肉芽腫性疾患における高カルシウム血症 hypercalcemia in granulomatous diseases
2. ビタミンDと骨外健康 vitamin d and extraskeletal health
3. カルシウムおよびリン酸バランスの調節 regulation of calcium and phosphate balance
4. 小児における低カルシウム血症性くる病の病因および治療 etiology and treatment of calcipenic rickets in children
5. ビタミンDの概要 overview of vitamin d

English Journal

Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study.

Schmidt RJ1, Hansen RL2, Hartiala J3, Allayee H4, Sconberg JL5, Schmidt LC6, Volk HE7, Tassone F8.
Early human development.Early Hum Dev.2015 Aug;91(8):483-9. doi: 10.1016/j.earlhumdev.2015.05.008. Epub 2015 Jun 11.
BACKGROUND: Vitamin D is essential for proper neurodevelopment and cognitive and behavioral function. We examined associations between autism spectrum disorder (ASD) and common, functional polymorphisms in vitamin D pathways.METHODS: Children aged 24-60months enrolled from 2003 to 2009 in the popula
PMID 26073892

Excess 25-hydroxyvitamin D3 exacerbates tubulointerstitial injury in mice by modulating macrophage phenotype.

Kusunoki Y1, Matsui I1, Hamano T2, Shimomura A1, Mori D1, Yonemoto S1, Takabatake Y1, Tsubakihara Y2, St-Arnaud R3, Isaka Y1, Rakugi H1.
Kidney international.Kidney Int.2015 Jul 15. doi: 10.1038/ki.2015.210. [Epub ahead of print]
Vitamin D hydroxylated at carbon 25 (25(OH)D) is generally recognized as a precursor of active vitamin D. Despite its low affinity for the vitamin D receptor (VDR), both deficient and excessive 25(OH)D levels are associated with poor clinical outcomes. Here we studied direct effects of 25(OH)D3 on t
PMID 26176830

Hepatocellular carcinoma cells express 25(OH)D-1α-hydroxylase and are able to convert 25(OH)D to 1α,25(OH)2D, leading to the 25(OH)D-induced growth inhibition.

Chiang KC1, Yen CL2, Yeh CN3, Hsu JT3, Chen LW2, Kuo SF4, Wang SY3, Sun CC5, Kittaka A6, Chen TC7, Yeh TS3, Hsu SY8, Juang HH9.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2015 Jul 10. pii: S0960-0760(15)30008-X. doi: 10.1016/j.jsbmb.2015.06.008. [Epub ahead of print]
Hepatocellular carcinoma (HCC) is the most diagnosed liver cancer without effective treatments available for advanced HCC. Vitamin D is getting popular due to its anti-cancer characteristics. However, the clinical application of 1α,25(OH)2D, the active form of vitamin, is hampered by its hypercalce
PMID 26170242

Japanese Journal

25-ヒドロキシビタミンDの生理機能

ビタミン 88(3), 158-160, 2014-03
NAID 40020032703

Activated Vitamin D3 and Pro-activated Vitamin D3 Attenuate Induction of Permanent Changes Caused by Neonatal Estrogen Exposure in the Mouse Vagina

MATSUDA Manabu,KUROSAKI Keiko,OKAMURA Naomichi
Journal of Reproduction and Development, 2014
… Correspondingly, expression of Cyp27B1, a kidney-specific 25-hydroxyvitamin D hydroxylase, was evident in the neonatal mouse vagina when examined by RT-PCR. …
NAID 130003390842

ビタミンDとシトクロムP450の遺伝子多型(<特集>「ビタミンと遺伝子多型」-ビタミンD-)

榊利之,西川美宇
ビタミン 87(9), 519-524, 2013-09-25
… CYP2R1 catalyzes conversion of vitamin D_3 to 25-hydroxyvitamin D_3 (25OHD3), while CYP27B1 catalyzes conversion of 25OHD_3 to 1α, 25-dihydroxyvitamin D_3 (1,25(OH)2D3), the active form of vitamin D_3 On the contrary, CYP24A1 inactivates 1,25(OH)2D3 by multi-step monooxygenation reactions. … More than 30 CYP27B1 mutations containing missense and nonsense mutations have been found in vitaminD-dependent rickets type I (VDDR1) patients, while 3 types of CYP2R1 mutation were found in VDDR1 patients. …
NAID 110009636194

Related Pictures

HUMAN MICROBIOTA IN HEALTH AND DISEASE - Selfcare Journal Variabilidad de genes del metabolismo de la vitamina D asociada con la infección por Search - UCLA Orthopaedic Surgery, Los Angeles & Santa Monica, CA Pike Lab deciphers final pieces of Vitamin D regulatory pathway – eCALS Innate Immune Effectors in Mycobacterial Infection : Figure 3 Anti-CYP27B1 antibody (ab95047) | Abcam CYP24A1 and CYP27B1 Polymorphisms Modulate Vitamin D Metabolism in Colon Cancer Cells Novel Vitamin D Analogs for Prostate Cancer Therapy : Figure 7

★リンクテーブル★

リンク元	「CYP17B1タンパク質」

「CYP17B1タンパク質」

Search
PMC	articles
PubMed	articles
NCBI	proteins

calcidiol 1-monooxygenase
Identifiers
EC number	1.14.13.13
CAS number	9081-36-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search
PMC	articles
PubMed	articles
NCBI	proteins

Cytochrome P450, family 27, subfamily B, polypeptide 1
Identifiers
Symbols	CYP27B1 ; CP2B; CYP1; CYP1alpha; CYP27B; P450c1; PDDR; VDD1; VDDR; VDDRI; VDR
External IDs	OMIM: 609506 MGI: 1098274 HomoloGene: 37139 IUPHAR: 1370 ChEMBL: 5993 GeneCards: CYP27B1 Gene
EC number	1.14.13.13
Gene ontology
Molecular function	• calcidiol 1-monooxygenase activity; • iron ion binding; • heme binding;
Cellular component	• cytoplasm; • mitochondrion; • mitochondrial outer membrane;
Biological process	• vitamin metabolic process; • xenobiotic metabolic process; • calcium ion transport; • steroid metabolic process; • negative regulation of cell proliferation; • negative regulation of calcidiol 1-monooxygenase activity; • positive regulation of vitamin D 24-hydroxylase activity; • bone mineralization; • negative regulation of cell growth; • regulation of bone mineralization; • response to lipopolysaccharide; • response to vitamin D; • response to interferon-gamma; • calcitriol biosynthetic process from calciol; • vitamin D metabolic process; • vitamin D catabolic process; • response to estrogen; • small molecule metabolic process; • positive regulation of keratinocyte differentiation; • decidualization; • calcium ion homeostasis; • oxidation-reduction process; • G1 to G0 transition; • positive regulation of vitamin D receptor signaling pathway;
	Sources: Amigo / QuickGO
Orthologs
	v; t; e;

　　[★]

英

(n

CYP27B1

関: 25-ヒドロキシビタミンD3-1α水酸化酵素

[WikiPathways-7] The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".

[entrez-1] "Entrez Gene: cytochrome P450".

[pmid9295274-2] Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S (Sep 1997). "25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis". Science 277 (5333): 1827–30. doi:10.1126/science.277.5333.1827. PMID 9295274.

[pmid9344864-3] Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T (Oct 1997). "Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase". Biochemical and Biophysical Research Communications 239 (2): 527–33. doi:10.1006/bbrc.1997.7508. PMID 9344864.

[pmid17259988-4] Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC (Mar 2007). "DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27" (PDF). Nature Immunology 8 (3): 285–93. doi:10.1038/ni1433. PMID 17259988.

[pmid20739402-5] Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ (Oct 2010). "Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption". Endocrinology 151 (10): 4613–25. doi:10.1210/en.2010-0334. PMID 20739402.

[pmid4404596-6] Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF (Dec 1972). "25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties". The Journal of Biological Chemistry 247 (23): 7528–32. PMID 4404596.

匿名

検索

案内

案内

CYP27B1