- 関
- cytochrome P-450 CYP1A2
- 同
- cytochrome C450 1A2
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/09 16:47:39」(JST)
[Wiki ja表示]
シトクロムP450 1A2は、略称CYP1A2と呼ばれ、シトクロムP450混合機能オキシダーゼのメンバーのひとつであり、人体において生体異物(英語版)の代謝に関与している。
CYP1A2の発現は、様々な栄養成分によって誘導されるとみなされている[1]。
目次
- 1 CYP1A2のリガンド
- 2 脚注
- 3 さらに読む
- 4 関連項目
CYP1A2のリガンド
CYP1A21の選択的な基質、誘導剤および阻害剤の表
基質 |
阻害剤 |
誘導剤 |
よく言及される [2]:
- 一部の抗うつ薬
- アミトリプチン (三環系抗うつ薬)
- イミプラミン (抗うつ薬)
- クロミプラミン (三環系抗うつ薬)
- クロザピン (非定型抗精神病薬)
- カフェイン (精神刺激薬)
- オランザピン (非定型抗精神病薬)
- ロピバカイン (局所麻酔薬)
- テオフィリン (キサンチン)
- ゾルミトリプタン (セロトニン受容体アゴニスト)
他:
- シクロベンザプリン (筋弛緩薬, 抑制剤)
- エストラジオール
- フルボキサミン (SSRI系抗うつ薬)
- ハロペリドール (定型抗精神病薬)
- オンダンセトロン (5-HT3受容体拮抗薬)
- メキシレチン (抗不整脈薬)
- メラトニン (抗酸化物質、睡眠誘導)
- タモキシフェン (SERM)
- ナプロキセン (NSAID)
- パラセタモール (鎮痛剤, 解熱剤)
- ワルファリン (抗凝固剤)
- リドカイン (局所麻酔薬, 抗不整脈薬)
|
強力 [3]:
- シプロフロキサシン (フルオロキノロン系殺菌剤)
- 多くの他のフルオロキノロン (広域スペクトル抗生物質(英語版))
- フルボキサミン (SSRI系抗うつ薬)
- ベラパミル (カルシウム拮抗剤)
詳細不明:
- グレープフルーツジュース (苦味のあるフラボノイドのナリンゲニンを含む)[4]
- アミオダロン (抗不整脈薬)
- シメチジン (ヒスタミンH2受容体拮抗薬)
- フラフィリン
- インターフェロン (抗ウイルス薬, 殺菌剤, 抗がん剤)
- メトキサレン (乾癬に用いる)
- カフェイン (精神刺激薬)
- エキナセア (免疫増強薬)
- エノキサシン (抗生物質)
- メキシレチン (抗不整脈薬)
- ホルモン避妊薬(英語版)
- ジレウトン (喘息に用いる)
|
よく言及される[2]:
他:
- 一部の食品
- インスリン (糖尿病に用いる)
- モダフィニル (覚醒剤)
- ナフシリン (β-ラクタム系抗生物質)
- オメプラゾール (プロトンポンプ阻害薬)
- ハイパフォリンは、セント・ジョーンズ・ワートの成分(抗うつ薬)
- カルバマゼピン (抗てんかん薬)
- フェノバルビタール (抗てんかん薬)
- リファンピシン (殺菌剤)
|
脚注
- ^ Fontana R, Lown K, Paine M, Fortlage L, Santella R, Felton J, Knize M, Greenberg A, Watkins P (1999). "Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers". Gastroenterology 117 (1): 89–98. doi:10.1016/S0016-5085(99)70554-8. PMID 10381914.
- ^ a b Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
- ^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)
- ^ Edwards DJ, Bernier SM (1996). "Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man". Life Sciences 59 (13): 1025–1030. doi:10.1016/0024-3205(96)00417-1. PMID 8485024.
- Meijerman I, Beijnen J, Schellens J (2006). "Herb-drug interactions in oncology: focus on mechanisms of induction". Oncologist 11 (7): 742–52. doi:10.1634/theoncologist.11-7-742. PMID 16880233.
さらに読む
- Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.
- Landi MT, Sinha R, Lang NP, Kadlubar FF (1999). "Human cytochrome P4501A2.". IARC Sci. Publ. (148): 173–95. PMID 10493258.
- Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP)genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
- Ikeya K, Jaiswal AK, Owens RA, et al. (1990). "Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.". Mol. Endocrinol. 3 (9): 1399–408. PMID 2575218.
- Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF (1989). "Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.". Proc. Natl. Acad. Sci. U.S.A. 86 (20): 7696–700. doi:10.1073/pnas.86.20.7696. PMID 2813353.
- Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH (1986). "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.". DNA 4 (5): 395–400. PMID 3000715.
- Quattrochi LC, Pendurthi UR, Okino ST, et al. (1986). "Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.". Proc. Natl. Acad. Sci. U.S.A. 83 (18): 6731–5. doi:10.1073/pnas.83.18.6731. PMID 3462722.
- Wrighton SA, Campanile C, Thomas PE, et al. (1986). "Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.". Mol. Pharmacol. 29 (4): 405–10. PMID 3517618.
- Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ (1988). "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15.". J. Exp. Pathol. 3 (1): 1–17. PMID 3681487.
- Jaiswal AK, Nebert DW, Gonzalez FJ (1986). "Human P3(450): cDNA and complete amino acid sequence.". Nucleic Acids Res. 14 (16): 6773–4. doi:10.1093/nar/14.16.6773. PMID 3755823.
- Eugster HP, Probst M, Würgler FE, Sengstag C (1993). "Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.". Drug Metab. Dispos. 21 (1): 43–9. PMID 8095225.
- Schweikl H, Taylor JA, Kitareewan S, et al. (1994). "Expression of CYP1A1 and CYP1A2 genes in human liver.". Pharmacogenetics 3 (5): 239–49. doi:10.1097/00008571-199310000-00003. PMID 8287062.
- Yamazaki H, Inoue K, Mimura M, et al. (1996). "7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes.". Biochem. Pharmacol. 51 (3): 313–9. doi:10.1016/0006-2952(95)02178-7. PMID 8573198.
- Hakkola J, Raunio H, Purkunen R, et al. (1996). "Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.". Biochem. Pharmacol. 52 (2): 379–83. doi:10.1016/0006-2952(96)00216-X. PMID 8694864.
- Guengerich FP, Johnson WW (1998). "Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.". Biochemistry 36 (48): 14741–50. doi:10.1021/bi9719399. PMID 9398194.
- Wacke R, Kirchner A, Prall F, et al. (1998). "Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis.". Pancreas 16 (4): 521–8. doi:10.1097/00006676-199805000-00011. PMID 9598815.
- Macé K, Bowman ED, Vautravers P, et al. (1998). "Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.". Eur. J. Cancer 34 (6): 914–20. doi:10.1016/S0959-8049(98)00034-3. PMID 9797707.
- Huang JD, Guo WC, Lai MD, et al. (1999). "Detection of a novel cytochrome P-450 1A2 polymorphism (F21L)in Chinese.". Drug Metab. Dispos. 27 (1): 98–101. PMID 9884316.
- Tatemichi M, Nomura S, Ogura T, et al. (1999). "Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia.". Cancer Res. 59 (16): 3893–8. PMID 10463577.
関連項目
[Wiki en表示]
Cytochrome P450, family 1, subfamily A, polypeptide 2 |
PDB rendering based on 2hi4.
|
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
2HI4
|
|
|
Identifiers |
Symbols |
CYP1A2 ; CP12; P3-450; P450(PA) |
External IDs |
OMIM: 124060 MGI: 88589 HomoloGene: 68082 IUPHAR: 1319 ChEMBL: 3356 GeneCards: CYP1A2 Gene |
EC number |
1.14.14.1 |
Gene ontology |
Molecular function |
• monooxygenase activity
• iron ion binding
• electron carrier activity
• oxidoreductase activity
• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
• enzyme binding
• heme binding
• demethylase activity
• caffeine oxidase activity
• aromatase activity
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Cellular component |
• endoplasmic reticulum membrane
• intracellular membrane-bounded organelle
|
Biological process |
• steroid catabolic process
• porphyrin-containing compound metabolic process
• xenobiotic metabolic process
• toxin biosynthetic process
• post-embryonic development
• alkaloid metabolic process
• regulation of gene expression
• monoterpenoid metabolic process
• drug metabolic process
• dibenzo-p-dioxin metabolic process
• arachidonic acid metabolic process
• epoxygenase P450 pathway
• lung development
• methylation
• response to estradiol
• response to lipopolysaccharide
• monocarboxylic acid metabolic process
• drug catabolic process
• exogenous drug catabolic process
• small molecule metabolic process
• cellular respiration
• heterocycle metabolic process
• hydrogen peroxide biosynthetic process
• oxidation-reduction process
• oxidative demethylation
• cellular response to cadmium ion
• oxidative deethylation
• omega-hydroxylase P450 pathway
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Sources: Amigo / QuickGO |
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RNA expression pattern |
|
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
1544 |
13077 |
Ensembl |
ENSG00000140505 |
ENSMUSG00000032310 |
UniProt |
P05177 |
P00186 |
RefSeq (mRNA) |
NM_000761 |
NM_009993 |
RefSeq (protein) |
NP_000752 |
NP_034123 |
Location (UCSC) |
Chr 15:
75.04 – 75.05 Mb |
Chr 9:
57.68 – 57.68 Mb |
PubMed search |
[1] |
[2] |
|
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.[1] In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene.[2]
Contents
- 1 Function
- 2 Effect of diet
- 3 Ligands
- 4 References
- 5 Further reading
- 6 See also
Function
CYP1A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP1A2 localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.[3]
Effect of diet
Expression of CYP1A2 appears to be induced by various dietary constituents.[4] Vegetables such as cabbages, cauliflower and broccoli are known to increase levels of CYP1A2. Lower activity of CYP1A2 in South Asians appears to be due to cooking these vegetables in curries using ingredients such as cumin and turmeric, ingredients known to inhibit the enzyme.[5]
Ligands
Following is a table of selected substrates, inducers and inhibitors of CYP1A2.
Inhibitors of CYP1A2 can be classified by their potency, such as:
- Strong inhibitor being one that causes at least a 5-fold increase in the plasma AUC values, or more than 80% decrease in clearance.[6]
- Moderate inhibitor being one that causes at least a 2-fold increase in the plasma AUC values, or 50-80% decrease in clearance.[6]
- Weak inhibitor being one that causes at least a 1.25-fold but less than 2-fold increase in the plasma AUC values, or 20-50% decrease in clearance.[6]
Substrates |
Inhibitors |
Inducers |
- many antidepressants
- amitriptyline[6][7] (tricyclic antidepressant)
- clomipramine[6][7] (tricyclic antidepressant)
- imipramine[6][7] (tricyclic antidepressant)
- agomelatine
- some atypical antipsychotics
- clozapine[6][7]
- olanzapine[6][7]
- haloperidol[6][7] (typical antipsychotic)
- caffeine[6][7] (xanthine, stimulant)
- ropivacaine[6][7] (local anaesthetic)
- theophylline[6][7] (xanthine, in respiratory diseases)
- zolmitriptan[6][7] (serotonin receptor agonist)
- melatonin[7] (antioxidant, sleep-inducer)
- tamoxifen[7] (SERM)
- erlotinib[8] (Tarceva, a tyrosine kinase inhibitor)
- cyclobenzaprine[6] (muscle relaxant, depressant)
- estradiol[6] (in hypoestrogenism)
- fluvoxamine[6] (SSRI antidepressant)
- mexiletine[6] (antiarrhythmic agent)
- naproxen[6] (NSAID)
- ondansetron[6] (5-HT3 antagonist)
- phenacetin[6] (analgesic)
- paracetamol[6] (analgesic, antipyretic)
- propranolol[6] (beta blocker)
- riluzole[6] (in amyotrophic lateral sclerosis)
- tacrine[6] (parasympathomimetic)
- tizanidine[6] (α-2 adrenergic agonist)
- verapamil[6] (calcium channel blocker)
- warfarin[6] (anticoagulant)
- zileuton[6] (in asthma)
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Strong:
- ciprofloxacin[6][7] (fluoroquinolone bactericidal)
- Many other fluoroquinolones (broad-spectrum antibiotics)
- fluvoxamine[7][6] (SSRI antidepressant)
- verapamil[7] (calcium channel blocker)
Moderate
- St. John's wort[9]
- Herbs and herbal Teas
- Peppermint, German Chamomile(Chamazulene), and Dandelion Teas[10]
Weak
- cimetidine[6] (H2-receptor antagonist)
- caffeine[11]
Unspecified potency:
- amiodarone[6] (antiarrhythmic agent)
- interferon[6] (antiviral, antiseptic, antioncogenic)
- methoxsalen[6] (in psoriasis)
- Mibefradil[6] (calcium channel blocker)
- Some foods
- grapefruit juice (its bitter flavanone naringenin)[12]
- cumin[5]
- turmeric[5]
- isoniazid[13]
|
- Some foods/herbs
- broccoli[6][5]
- brussels sprouts[6]
- Echinacea[14]
- chargrilled meat[6]
- cauliflower[5]
- insulin[6] (in diabetes)
- Methylcholanthrene[6] (carcinogen)
- modafinil[6] (eugeroic)
- nafcillin[6] (beta-lactam antibiotic)
- beta-Naphthoflavone[6] (chemopreventive)
- omeprazole[6] (proton pump inhibitor)
|
References
- ^ Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (January 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
- ^ Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ (1987). "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15". J. Exp. Pathol. 3 (1): 1–17. PMID 3681487.
- ^ "Entrez Gene: cytochrome P450".
- ^ Fontana R, Lown K, Paine M, Fortlage L, Santella R, Felton J, Knize M, Greenberg A, Watkins P (1999). "Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers". Gastroenterology 117 (1): 89–98. doi:10.1016/S0016-5085(99)70554-8. PMID 10381914.
- ^ a b c d e Sanday, Kate (17 October 2011), "South Asians and Europeans react differently to common drugs", University of Sydney Faculty of Pharmacy News
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as Flockhart DA (2007). "Drug Interactions: Cytochrome P450 Drug Interaction Table". Indiana University School of Medicine. Retrieved on July 2011
- ^ a b c d e f g h i j k l m n o p Swedish environmental classification of pharmaceuticals - FASS (drug catalog) - Facts for prescribers (Fakta för förskrivare). Retrieved July 2011
- ^ "Erlotinib".
Metabolized primarily by CYP3A4 and, to a lesser degree, by CYP1A2 and the extrahepatic isoform CYP1A1
- ^ Dostalek M, Pistovcakova J, Jurica J, Tomandl J, Linhart I, Sulcová A, Hadasova E (2011). "The effect of St John's wort (hypericum perforatum) on cytochrome p450 1a2 activity in perfused rat liver". Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc, Czech Republic 155 (3): 253–258. doi:10.5507/bp.2011.047. PMID 22286810.
- ^ Maliakal, Pius. "Effect of herbal teas on hepatic drug metabolizing enzymes in rats". Journal of Pharmacy and Pharmacology. Retrieved 29 December 2012.
- ^ http://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm
- ^ Edwards DJ, Bernier SM (1996). "Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man". Life Sciences 59 (13): 1025–1030. doi:10.1016/0024-3205(96)00417-1. PMC 1381556. PMID 8485024.
- ^ Wen X, Wang JS, Neuvonen PJ, Backman JT. "Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes.". PMID 11868802.
- ^ Gorski JC, Huang SM, Pinto A, Hamman MA, Hilligoss JK, Zaheer NA, Desai M, Miller M, Hall SD (January 2004). "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo". Clin. Pharmacol. Ther. 75 (1): 89–100. doi:10.1016/j.clpt.2003.09.013. PMID 14749695.
Further reading
- Meijerman I, Beijnen J, Schellens J (2006). "Herb-drug interactions in oncology: focus on mechanisms of induction". Oncologist 11 (7): 742–52. doi:10.1634/theoncologist.11-7-742. PMID 16880233.
- Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.
- Landi MT, Sinha R, Lang NP, Kadlubar FF (1999). "Human cytochrome P4501A2.". IARC Sci. Publ. (148): 173–95. PMID 10493258.
- Ikeya K, Jaiswal AK, Owens RA et al. (1990). "Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.". Mol. Endocrinol. 3 (9): 1399–408. doi:10.1210/mend-3-9-1399. PMID 2575218.
- Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF (1989). "Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.". Proc. Natl. Acad. Sci. U.S.A. 86 (20): 7696–700. doi:10.1073/pnas.86.20.7696. PMC 298137. PMID 2813353.
- Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH (1986). "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.". DNA 4 (5): 395–400. doi:10.1089/dna.1985.4.395. PMID 3000715.
- Quattrochi LC, Pendurthi UR, Okino ST et al. (1986). "Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.". Proc. Natl. Acad. Sci. U.S.A. 83 (18): 6731–5. doi:10.1073/pnas.83.18.6731. PMC 386583. PMID 3462722.
- Wrighton SA, Campanile C, Thomas PE et al. (1986). "Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.". Mol. Pharmacol. 29 (4): 405–10. PMID 3517618.
- Jaiswal AK, Nebert DW, Gonzalez FJ (1986). "Human P3(450): cDNA and complete amino acid sequence.". Nucleic Acids Res. 14 (16): 6773–4. doi:10.1093/nar/14.16.6773. PMC 311685. PMID 3755823.
- Eugster HP, Probst M, Würgler FE, Sengstag C (1993). "Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.". Drug Metab. Dispos. 21 (1): 43–9. PMID 8095225.
- Schweikl H, Taylor JA, Kitareewan S et al. (1994). "Expression of CYP1A1 and CYP1A2 genes in human liver.". Pharmacogenetics 3 (5): 239–49. doi:10.1097/00008571-199310000-00003. PMID 8287062.
- Yamazaki H, Inoue K, Mimura M et al. (1996). "7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes.". Biochem. Pharmacol. 51 (3): 313–9. doi:10.1016/0006-2952(95)02178-7. PMID 8573198.
- Hakkola J, Raunio H, Purkunen R et al. (1996). "Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.". Biochem. Pharmacol. 52 (2): 379–83. doi:10.1016/0006-2952(96)00216-X. PMID 8694864.
- Guengerich FP, Johnson WW (1998). "Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.". Biochemistry 36 (48): 14741–50. doi:10.1021/bi9719399. PMID 9398194.
- Wacke R, Kirchner A, Prall F et al. (1998). "Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis.". Pancreas 16 (4): 521–8. doi:10.1097/00006676-199805000-00011. PMID 9598815.
- Macé K, Bowman ED, Vautravers P et al. (1998). "Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.". Eur. J. Cancer 34 (6): 914–20. doi:10.1016/S0959-8049(98)00034-3. PMID 9797707.
- Huang JD, Guo WC, Lai MD et al. (1999). "Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese.". Drug Metab. Dispos. 27 (1): 98–101. PMID 9884316.
- Tatemichi M, Nomura S, Ogura T et al. (1999). "Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia.". Cancer Res. 59 (16): 3893–8. PMID 10463577.
See also
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
PDB gallery
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2hi4: Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone
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Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
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CYP1 |
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CYP2 |
- A6
- A7
- A13
- B6
- C8
- C9
- C18
- C19
- D6
- E1
- F1
- J2
- R1
- S1
- U1
- W1
|
|
CYP3 (CYP3A) |
|
|
CYP4 |
- A11
- A22
- B1
- F2
- F3
- F8
- F11
- F12
- F22
- V2
- X1
- Z1
|
|
CYP5-20 |
- CYP5 (A1)
- CYP7 (A1, B1)
- CYP8 (A1, B1)
- CYP11 (A1, B1, B2)
- CYP17 (A1)
- CYP19 (A1)
- CYP20 (A1)
|
|
CYP21-51 |
- CYP21 (A2)
- CYP24 (A1)
- CYP26 (A1, B1, C1)
- CYP27 (A1, B1, C1)
- CYP39 (A1)
- CYP46 (A1)
- CYP51 (A1)
|
|
UpToDate Contents
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English Journal
- Genetic polymorphism analysis of the drug-metabolizing enzyme CYP1A2 in a Uyghur Chinese population: a pilot study.
- Geng T1,2,3, Zhang XY1, Wang L4, Wang H1, Shi X1, Kang L4, Hou P1, Jin T1,4.
- Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2016 Jun;46(6):542-7. doi: 10.3109/00498254.2015.1089367. Epub 2015 Sep 18.
- 1. CYP1A2 is a highly polymorphic gene and CYP1A2 enzyme results in broad inter-individual variability in response to certain pharmacotherapies, while little is known about the genetic variation of CYP1A2 in Uyghur Chinese population. The aim of the present study was to screen Uyghur volunteers fo
- PMID 26383175
- The different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes.
- Shi X1,2, Yang S3, Zhang G4, Song Y5, Su D5, Liu Y5, Guo F1, Shan L1,2, Cai J1.
- Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2016 May;46(5):467-76. doi: 10.3109/00498254.2015.1086839. Epub 2015 Sep 15.
- 1. The aim of this study was to investigate the inhibitory effect of morusin on Glucuronosyltransferase (UGT) isoforms and cytochrome P450 enzymes (CYP450s). We also investigated the metabolism of morusin in human, rat, dog, monkey, and minipig liver microsomes. 2. 100 μM of morusin exhibited
- PMID 26372370
- Tandem mass spectrometric analysis of S- and N-linked glutathione conjugates of pulegone and menthofuran and identification of P450 enzymes mediating their formation.
- Lassila T1,2, Mattila S1, Turpeinen M2,3, Pelkonen O2, Tolonen A4.
- Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2016 Apr 15;30(7):917-26. doi: 10.1002/rcm.7518.
- RATIONALE: Menthofuran is a hepatotoxin and a major metabolite of pulegone, a monoterpene found in the essential oils of many mint species. It is bioactivated by cytochrome P450 (CYP) enzymes to reactive metabolites, which may further react with glutathione to form S-linked and N-linked conjugates.
- PMID 26969934
Japanese Journal
- Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury
- Li San-Qiang,Zhu Sha,Wan Xue-Dong [他]
- The Journal of toxicological sciences : an official journal of the Japanese Society of Toxicology 39(2), 339-351, 2014-04
- NAID 40020063625
- Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection
- Ghoshal Ujjala,Tripathi Shweta,Kumar Sushil [他]
- Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 17(2), 226-234, 2014
- NAID 40020215995
- Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro
- Pan Yan,Tiong Kai Hung,Abd-Rashid Badrul Amini [他]
- Journal of natural medicines 68(2), 402-406, 2014
- NAID 40020023336
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- CYP1A2は、全CYP中の10~15%を占め、主に肺そして肝臓に存在します。喫煙や炭火焼の食品などの摂取で、誘導を受けやすい(増えやすい)といった特徴があります。 遺伝子多型としては、通常型の *1A、低活性型の *1C、そして誘導を ...
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