CDCA

ケノデオキシコール酸 chenodeoxycholic acid

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1. certificate of deposit / (また『C.D.』)Civil Defense民間防衛

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/24 12:32:57」(JST)

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United States District Court for the Central District of California (C.D. Cal.)
Map
Divisions of the CDCA: Eastern Division in yellow, Southern Division in red, Western Division in blue
Appeals to	Ninth Circuit
Established	September 18, 1966
Judges assigned	28
Chief judge	George H. King
Official site

The United States District Court for the Central District of California (in case citations, C.D. Cal.; commonly referred to as the CDCA or CACD) serves over 19 million people in Southern and Central California, making it the most populous federal judicial district. The district was created on September 18, 1966.

Cases from the Central District are appealed to the United States Court of Appeals for the Ninth Circuit (except for patent claims and claims against the United States government under the Tucker Act, which are appealed to the Federal Circuit).

History

California was admitted as a state on September 9, 1850, and was initially divided into two districts, the Northern and the Southern, by Act of Congress approved September 28, 1850, 9 Stat. 521. The boundary line was at the 37th parallel of North Latitude. The Southern District of California was abolished and the State made to constitute a single district – the United States District Court for the District of California – by Act of Congress approved July 27, 1866, 14 Stat. 300. Twenty years later, on August 5, 1886, Congress re-created the Southern District of California by 24 Stat. 308, but it was not until March 18, 1966, that the Eastern and Central Districts were created from portions of the Northern and Southern Districts by 80 Stat. 75.

Divisions

The U.S. District Court for the Central District of California is divided into three divisions, with jurisdiction over seven counties: Riverside, San Bernardino, Orange, Los Angeles, San Luis Obispo, Santa Barbara, and Ventura.

The Eastern Division covers Riverside and San Bernardino Counties at the Riverside courthouse.

The Southern Division covers Orange County from the Ronald Reagan Federal Building and Courthouse in Santa Ana.

The Western Division covers Los Angeles, San Luis Obispo, Santa Barbara, and Ventura Counties. Cases are heard in two courthouses in downtown Los Angeles, the older Spring Street Courthouse and the newer Edward R. Roybal Courthouse.

U.S. Attorney

The United States Attorney for the Central District represents the United States Government in civil and criminal cases before the court. Eileen Maura Decker is the current U.S. Attorney, being confirmed by the Senate on June 11, 2015.

Current district judges

#	Title	Judge	Duty station	Born	Term of service			Appointed by
					Active	Chief	Senior
49	Chief Judge	George H. King	Los Angeles	1951	1995–present	2012–present	—	Clinton
12	District Judge	Manuel Real	Los Angeles	1924	1966–present	1982–1993	—	L. Johnson
37	District Judge	Stephen Victor Wilson	Los Angeles	1941	1985–present	—	—	Reagan
51	District Judge	Dean D. Pregerson	Los Angeles	1951	1996–present	—	—	Clinton
52	District Judge	Christina A. Snyder	Los Angeles	1947	1997–present	—	—	Clinton
54	District Judge	Margaret M. Morrow	Los Angeles	1950	1998–present	—	—	Clinton
56	District Judge	David O. Carter	Santa Ana	1944	1998–present	—	—	Clinton
60	District Judge	Virginia A. Phillips	Riverside	1957	1999–present	—	—	Clinton
61	District Judge	Percy Anderson	Los Angeles	1948	2002–present	—	—	G.W. Bush
62	District Judge	John F. Walter	Los Angeles	1944	2002–present	—	—	G.W. Bush
63	District Judge	Robert G. Klausner	Los Angeles	1941	2002–present	—	—	G.W. Bush
64	District Judge	S. James Otero	Los Angeles	1951	2002–present	—	—	G.W. Bush
65	District Judge	James V. Selna	Santa Ana	1945	2003–present	—	—	G.W. Bush
66	District Judge	Cormac J. Carney	Santa Ana	1959	2003–present	—	—	G.W. Bush
67	District Judge	Dale S. Fischer	Los Angeles	1951	2003–present	—	—	G.W. Bush
70	District Judge	Andrew J. Guilford	Santa Ana	1950	2006–present	—	—	G.W. Bush
72	District Judge	Philip S. Gutierrez	Los Angeles	1959	2007–present	—	—	G.W. Bush
73	District Judge	Otis D. Wright II	Los Angeles	1944	2007–present	—	—	G.W. Bush
74	District Judge	George H. Wu	Los Angeles	1950	2007–present	—	—	G.W. Bush
76	District Judge	Dolly M. Gee	Los Angeles	1959	2010–present	—	—	Obama
77	District Judge	Josephine L. Staton	Santa Ana	1961	2010–present	—	—	Obama
78	District Judge	John A. Kronstadt	Los Angeles	1951	2011–present	—	—	Obama
79	District Judge	Michael W. Fitzgerald	Los Angeles	1959	2012–present	—	—	Obama
80	District Judge	Jesus G. Bernal	Riverside	1963	2012–present	—	—	Obama
81	District Judge	Fernando M. Olguin	Los Angeles	1961	2013–present	—	—	Obama
82	District Judge	Beverly Reid O'Connell	Los Angeles	1965	2013–present	—	—	Obama
83	District Judge	André Birotte Jr.	Los Angeles	1966	2014–present	—	—	Obama
—	District Judge	Vacant	—	—	—	—	—	—
23	Senior Judge	Terry J. Hatter, Jr.	Los Angeles	1933	1979–2005	1998–2001	2005–present	Carter
26	Senior Judge	Consuelo Bland Marshall	Los Angeles	1936	1980–2005	2001–2005	2005–present	Carter
35	Senior Judge	William Duffy Keller	Los Angeles	1934	1984–1999	—	1999–present	Reagan
41	Senior Judge	Ronald S.W. Lew	Los Angeles	1941	1987–2006	—	2006–present	Reagan
48	Senior Judge	Robert Timlin	Los Angeles	1932	1994–2005	—	2005–present	Clinton
71	Senior Judge	Valerie Baker Fairbank	Los Angeles	1949	2007–2012	—	2012–present	G.W. Bush

Vacancies and pending nominations

Seat	Seat last held by	Vacancy reason	Date of vacancy	Nominee	Date of nomination
10	Audrey B. Collins	Retirement	August 1, 2014	Mark A. Young	July 16, 2015
8	Margaret M. Morrow	Retirement	October 29, 2015

Former district judges

#	Judge	State	Born/Died	Active service	Chief Judge	Senior status	Appointed by	Reason for termination
—	Yankwich, Leon ReneLeon Rene Yankwich	CA	1888–1975	—	—	1966–1975	Roosevelt, F.F. Roosevelt	death
—	Byrne, Sr., William MatthewWilliam Matthew Byrne, Sr.	CA	1896–1974	—	—	1966–1974	Truman, Truman	death
1	Hall, Peirson MitchellPeirson Mitchell Hall	CA	1894–1979	1966–1968	—	1968–1979	Roosevelt, F.F. Roosevelt	death
2	Clarke, ThurmondThurmond Clarke	CA	1902–1971	1966–1970	1966–1970	1970–1971	Eisenhower, Eisenhower	death
3	Stephens, Jr., Albert LeeAlbert Lee Stephens, Jr.	CA	1913–2001	1966–1979	1970–1979	1979–2001	Kennedy, Kennedy	death
4	Carr, Charles HardyCharles Hardy Carr	CA	1903–1976	1966–1973	—	1973–1976	Kennedy, Kennedy	death
5	Curtis, Jr., Jesse WilliamJesse William Curtis, Jr.	CA	1905–2008	1966–1975	—	1975–1990	Kennedy, Kennedy	retirement
6	Crary, Elisha AveryElisha Avery Crary	CA	1905–1978	1966–1975	—	1975–1978	Kennedy, Kennedy	death
7	Whelan, Francis C.Francis C. Whelan	CA	1907–1991	1966–1978	—	1978–1991	Johnson, L.L. Johnson	death
8	Hill, IrvingIrving Hill	CA	1915–1998	1966–1980	1979–1980	1980–1998	Johnson, L.L. Johnson	death
9	Andrew Hauk, A.A. Andrew Hauk	CA	1912–2004	1966–1982	1980–1982	1982–2004	Johnson, L.L. Johnson	death
10	Gray, William PercivalWilliam Percival Gray	CA	1912–1992	1966–1982	—	1982–1992	Johnson, L.L. Johnson	death
11	Ferguson, Warren JohnWarren John Ferguson	CA	1920–2008	1966–1979	—	—	Johnson, L.L. Johnson	reappointment
13	Pregerson, HarryHarry Pregerson	CA	1923–present	1967–1979	—	—	Johnson, L.L. Johnson	reappointment
14	Williams, David WelfordDavid Welford Williams	CA	1910–2000	1969–1981	—	1981–2000	Nixon, Nixon	death
15	Kelleher, Robert J.Robert J. Kelleher	CA	1913–2012	1970–1983	—	1983–2012	Nixon	death
16	Byrne, Jr., William MatthewWilliam Matthew Byrne, Jr.	CA	1930–2006	1971–1998	1994–1998	1998–2006	Nixon, Nixon	death
17	Lucas, Malcolm M.Malcolm M. Lucas	CA	1927–present	1971–1984	—	—	Nixon, Nixon	resignation
18	Lydick, Lawrence TupperLawrence Tupper Lydick	CA	1916–1995	1971–1984	—	1984–1995	Nixon, Nixon	death
19	Firth, RobertRobert Firth	CA	1918–1984	1974–1979	—	1979–1984	Nixon, Nixon	death
20	Takasugi, Robert MitsuhiroRobert Mitsuhiro Takasugi	CA	1930–2009	1976–1996	—	1996–2009	Ford, Ford	death
21	Waters, Sr., Laughlin EdwardLaughlin Edward Waters, Sr.	CA	1914–2002	1976–1986	—	1986–2002	Ford, Ford	death
22	Pfaelzer, MarianaMariana Pfaelzer	CA	1926–2015	1978–1997	—	1997–2015	Carter, Carter	death
24	Tashima, A. WallaceA. Wallace Tashima	CA	1934–present	1980–1996	—	—	Carter, Carter	reappointment
25	Kenyon, David VreelandDavid Vreeland Kenyon	CA	1930–present	1980–1995	—	1995–1997	Carter, Carter	retirement
27	Hall, Cynthia HolcombCynthia Holcomb Hall	CA	1929–2011	1981–1984	—	—	Reagan, Reagan	reappointment
28	Gadbois, Jr., Richard ArthurRichard Arthur Gadbois, Jr.	CA	1932–1996	1982–1996	—	1996	Reagan, Reagan	death
29	Rafeedie, EdwardEdward Rafeedie	CA	1929–2008	1982–1996	—	1996–2008	Reagan, Reagan	death
30	Rymer, Pamela AnnPamela Ann Rymer	CA	1941–2011	1983–1989	—	—	Reagan, Reagan	reappointment
31	Hupp, Harry LindleyHarry Lindley Hupp	CA	1929–2004	1984–1997	—	1997–2004	Reagan, Reagan	death
32	Stotler, Alicemarie HuberAlicemarie Huber Stotler	CA	1942–2014	1984–2009	2005–2009	2009–2014	Reagan, Reagan	death
33	Ideman, James M.James M. Ideman	CA	1931–present	1984–1998	—	1998	Reagan, Reagan	retirement
34	Rea, William J.William J. Rea	CA	1920–2005	1984–1998	—	1998–2005	Reagan, Reagan	death
36	Fernandez, Ferdinand FrancisFerdinand Francis Fernandez	CA	1937–present	1985–1989	—	—	Reagan, Reagan	reappointment
38	Letts, John SpencerJohn Spencer Letts	CA	1934–2014	1985–2000	—	2000–2014	Reagan, Reagan	death
39	Tevrizian, Jr., Dickran M.Dickran M. Tevrizian, Jr.	CA	1940–present	1985–2005	—	2005–2007	Reagan, Reagan	retirement
40	Davies, JohnJohn Davies	CA	1929–present	1986–1998	—	—	Reagan, Reagan	retirement
42	Bonner, Robert C.Robert C. Bonner	CA	1942–present	1989–1990	—	—	Bush, G.H.W.G.H.W. Bush	resignation
43	Taylor, Gary L.Gary L. Taylor	CA	1938–present	1990–2004	—	2004–2005	Bush, G.H.W.G.H.W. Bush	retirement
44	Baird, Lourdes GillespieLourdes Gillespie Baird	CA	1935–present	1992–2004	—	2004–2005	Bush, G.H.W.G.H.W. Bush	retirement
45	McLaughlin, Linda HodgeLinda Hodge McLaughlin	CA	1942–1999	1992–1999	—	—	Bush, G.H.W.G.H.W. Bush	death
46	Collins, Audrey B.Audrey B. Collins	CA	1945–present	1994–2014	2009–2012	—	Clinton	retirement
47	Paez, RichardRichard Paez	CA	1947–present	1994–2000	—	—	Clinton, Clinton	reappointment
50	Wardlaw, Kim McLaneKim McLane Wardlaw	CA	1954–present	1995–1998	—	—	Clinton, Clinton	reappointment
53	Moreno, Carlos R.Carlos R. Moreno	CA	1948–present	1998–2001	—	—	Clinton, Clinton	resignation
55	Matz, HowardHoward Matz	CA	1943–present	1998–2011	—	2011–2013	Clinton, Clinton	retirement
57	Manella, Nora MargaretNora Margaret Manella	CA	1951–present	1998–2006	—	—	Clinton, Clinton	resignation
58	Feess, Gary AllenGary Allen Feess	CA	1948–present	1999–2014	—	2014–2015	Clinton, Clinton	retirement
59	Cooper, Florence-MarieFlorence-Marie Cooper	CA	1940–2010	1999–2010	—	—	Clinton, Clinton	death
68	Schiavelli, George P.George P. Schiavelli	CA	1948–present	2004–2008	—	—	Bush, G.W.G.W. Bush	resignation
69	Larson, Stephen G.Stephen G. Larson	CA	1964–present	2006–2009	—	—	Bush, G.W.G.W. Bush	resignation
75	Nguyen, JacquelineJacqueline Nguyen	CA	1965–present	2009–2012	—	—	Obama, Obama	reappointment

Succession of seats

Seat 1
Seat reassigned from Southern District on September 18, 1966 by 80 Stat. 75
P. Hall	1966–1968
Williams	1969–1981
Rafeedie	1982–1996
Snyder	1997–present

Seat 2
Seat reassigned from Southern District on September 18, 1966 by 80 Stat. 75
Clarke	1966–1970
Lydick	1971–1984
Ideman	1984–1998
Feess	1999–2014
Birotte	2014–present

Seat 3
Seat reassigned from Southern District on September 18, 1966 by 80 Stat. 75
Stephens, Jr.	1966–1979
Kenyon	1980–1995
Wardlaw	1995–1998
Anderson	2002–present

Seat 4
Seat reassigned from Southern District on September 18, 1966 by 80 Stat. 75
Carr	1966–1973
Firth	1974–1979
Marshall	1980–2005
Fairbank	2007–2012
O'Connell	2013–present

Seat 5
Seat reassigned from Southern District on September 18, 1966 by 80 Stat. 75
Curtis, Jr.	1966–1975
Waters, Sr.	1976–1986
Lew	1987–2006
Wu	2007–present

Seat 6
Seat reassigned from Southern District on September 18, 1966 by 80 Stat. 75
Crary	1966–1975
Takasugi	1976–1996
Moreno	1998–2001
Carney	2003–present

Seat 7
Seat reassigned from Southern District on September 18, 1966 by 80 Stat. 75
Whelan	1966–1978
Pfaelzer	1978–1997
Manella	1998–2006
Nguyen	2009–2012
Olguin	2013–present

Seat 8
Seat reassigned from Southern District on September 18, 1966 by 80 Stat. 75
Hill	1966–1980
Gadbois, Jr.	1982–1996
Morrow	1998–present

Seat 9
Seat reassigned from Southern District on September 18, 1966 by 80 Stat. 75
Hauk	1966–1982
Hupp	1984–1997
Matz	1998–2011
Fitzgerald	2012–present

Seat 10
Seat reassigned from Southern District on September 18, 1966 by 80 Stat. 75
Gray	1966–1982
Rymer	1983–1989
Bonner	1989–1990
Collins	1994–2014
Vacant	2014-present

Seat 11
Seat established on September 18, 1966 by 80 Stat. 75
Ferguson	1966–1979
Tashima	1980–1996
D. Pregerson	1996–present

Seat 12
Seat established on September 18, 1966 by 80 Stat. 75
Real	1966–present

Seat 13
Seat established on September 18, 1966 by 80 Stat. 75
H. Pregerson	1967–1979
C. Hall	1981–1984
Davies	1986–1998
Walter	2002–present

Seat 14
Seat established on June 2, 1970 by 84 Stat. 294
Kelleher	1970–1983
Stotler	1984–2009
Tucker	2010–present

Seat 15
Seat established on June 2, 1970 by 84 Stat. 294
Byrne	1971–1998
Phillips	1999–present

Seat 16
Seat established on June 2, 1970 by 84 Stat. 294
Lucas	1971–1984
Rea	1984–1998
Carter	1998–present

Seat 17
Seat established on October 20, 1978 by 92 Stat. 1629
Hatter, Jr.	1979–2005
Gutierrez	2007–present

Seat 18
Seat established on July 10, 1984 by 98 Stat. 333
Keller	1984–1999
Klausner	2002–present

Seat 19
Seat established on July 10, 1984 by 98 Stat. 333
Fernandez	1985–1989
Taylor	1990–2004
Wright II	2007–present

Seat 20
Seat established on July 10, 1984 by 98 Stat. 333
Wilson	1985–present

Seat 21
Seat established on July 10, 1984 by 98 Stat. 333
Letts	1985–2000
Selna	2003–present

Seat 22
Seat established on July 10, 1984 by 98 Stat. 333
Tevrizian, Jr.	1985–2005
Guilford	2006–present

Seat 23
Seat established on December 1, 1990 by 104 Stat. 5089
Baird	1992–2004
Schiavelli	2004–2008
Gee	2010–present

Seat 24
Seat established on December 1, 1990 by 104 Stat. 5089
McLaughlin	1992–1999
Cooper	1999–2010
Kronstadt	2011–present

Seat 25
Seat established on December 1, 1990 by 104 Stat. 5089
Paez	1994–2000
Otero	2003–present

Seat 26
Seat established on December 1, 1990 by 104 Stat. 5089
Timlin	1994–2005
Larson	2006–2009
Bernal	2012–present

Seat 27
Seat established on December 1, 1990 by 104 Stat. 5089
King	1995–present

Seat 28
Seat established on November 2, 2002 by 116 Stat. 1758 (temporary)
Fischer	2003–present

See also

• Courts of California
• List of United States federal courthouses in California

Notes

External links

• United States District Court, Central District of California
• United States Attorney's Office, Central District of California

UpToDate Contents

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• 1. 脳腱黄色腫症 cerebrotendinous xanthomatosis
• 2. 胆石の溶解療法 dissolution therapy for the treatment of gallstones
• 3. Overview of the treatment of primary biliary cholangitis (primary biliary cirrhosis)
• 4. 遺伝性運動失調の概要 overview of the hereditary ataxias
• 5. 肝臓の有機アニオン輸送能および薬物代謝能の検査 tests of the livers capacity to transport organic anions and metabolize drugs

English Journal

• Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: Role of glycine conjugates.

• Chatterjee S1, Bijsmans IT2, van Mil SW3, Augustijns P4, Annaert P5.Author information 1KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, O&N2, Herestraat 49 - Bus 921, 3000 Leuven, Belgium. Electronic address: Sagnik.Chatterjee@pharm.kuleuven.be.2Department of Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: i.bijsmans@umcutrecht.nl.3Department of Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: s.w.c.vanmil@umcutrecht.nl.4KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, O&N2, Herestraat 49 - Bus 921, 3000 Leuven, Belgium. Electronic address: Patrick.Augustijns@pharm.kuleuven.be.5KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, O&N2, Herestraat 49 - Bus 921, 3000 Leuven, Belgium. Electronic address: Pieter.Annaert@pharm.kuleuven.be.AbstractExcessive intrahepatic accumulation of bile acids (BAs) is a key mechanism underlying cholestasis. The aim of this study was to quantitatively explore the relationship between cytotoxicity of BAs and their intracellular accumulation in sandwich-cultured rat hepatocytes (SCRH). Following exposure of SCRH (on day-1 after seeding) to various BAs for 24h, glycine-conjugated BAs were most potent in exerting toxicity. Moreover, unconjugated BAs showed significantly higher toxicity in day-1 compared to day-3 SCRH. When day-1/-3 SCRH were exposed (0.5-4h) to 5-100μM (C)DCA, intracellular levels of unconjugated (C)DCA were similar, while intracellular levels of glycine conjugates were up to 4-fold lower in day-3 compared to day-1 SCRH. Sinusoidal efflux was by far the predominant efflux pathway of conjugated BAs both in day-1 and day-3 SCRH, while canalicular BA efflux showed substantial interbatch variability. After 4h exposure to (C)DCA, intracellular glycine conjugate levels were at least 10-fold higher than taurine conjugate levels. Taken together, reduced BA conjugate formation in day-3 SCRH results in lower intracellular glycine conjugate concentrations, explaining decreased toxicity of (C)DCA in day-3 versus day-1 SCRH. Our data provide for the first time a direct link between BA toxicity and glycine conjugate exposure in SCRH.
• Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2014 Mar;28(2):218-30. doi: 10.1016/j.tiv.2013.10.020. Epub 2013 Nov 7.
• Excessive intrahepatic accumulation of bile acids (BAs) is a key mechanism underlying cholestasis. The aim of this study was to quantitatively explore the relationship between cytotoxicity of BAs and their intracellular accumulation in sandwich-cultured rat hepatocytes (SCRH). Following exposure of
• PMID 24211540

• Tandem mass spectrometric characterization of bile acids and steroid conjugates based on low-energy collision-induced dissociation.

• Maekawa M1, Shimada M1, Iida T2, Goto J1, Mano N3.Author information 1Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.2Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajousui, Setagaya-ku, Tokyo 156-8550, Japan.3Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Electronic address: mano@hosp.tohoku.ac.jp.AbstractWe examined the characteristics of several bile acids and some steroid conjugates under low-energy-collision-induced dissociation conditions using a triple quadrupole tandem mass spectrometer. According to conjugation types, we observed characteristic product ions and/or neutral losses in the product ion spectra. Amino acid conjugates afforded specific product ions. For example, glycine-conjugated metabolites routinely produced a product ion at m/z 74, and taurine-conjugated metabolites produced product ions at m/z 124, 107, and 80. When a strong peak appeared at m/z 97, the molecule contained a sulfate group. In contrast to amino acid conjugates, carbohydrate conjugates required a combination of product ions and neutral losses for identification. We could discriminate a glucoside from an acyl galactoside according to the presence or absence of a product ion at m/z 161 and a neutral loss of 180Da. Discrimination among esters, aliphatic ethers, and phenolic ether types of glucuronides was based upon differences in the intensities of a product ion at m/z 175 and a neutral loss of 176Da. Furthermore, N-acetylglucosamine conjugates showed a characteristic product ion at m/z 202 and a neutral loss of 203Da, and the appearance of a product ion at m/z 202 revealed the existence of N-acetylglucosamine conjugated to an aliphatic hydroxyl group without a double bond in the immediate vicinity. Together, the data presented here will help to enable the identification of unknown conjugated cholesterol metabolites by using low-energy collision-induced dissociation.
• Steroids.Steroids.2014 Feb;80:80-91. doi: 10.1016/j.steroids.2013.11.016. Epub 2013 Dec 1.
• We examined the characteristics of several bile acids and some steroid conjugates under low-energy-collision-induced dissociation conditions using a triple quadrupole tandem mass spectrometer. According to conjugation types, we observed characteristic product ions and/or neutral losses in the produc
• PMID 24296272

• A Possible Role of Chenodeoxycholic Acid and Glycine-Conjugated Bile Acids in Fibrotic Steatohepatitis in a Dietary Rat Model.

• Jia X, Suzuki Y, Naito H, Yetti H, Kitamori K, Hayashi Y, Kaneko R, Nomura M, Yamori Y, Zaitsu K, Kato M, Ishii A, Nakajima T.Author information Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.AbstractBACKGROUND AND AIMS: Our previous study indicated that hepatic bile acids (BAs) may have deposited and stimulated the pathogenesis of a high fat-cholesterol (HFC) diet-induced fibrotic steatohepatitis in stroke-prone spontaneously hypertensive 5/Dmcr rats, based on dysregulated BA homeostasis pathways. We aimed to further characterize BA profiles in liver and evaluate their relationships to liver injury using this model.
• Digestive diseases and sciences.Dig Dis Sci.2014 Jan 22. [Epub ahead of print]
• BACKGROUND AND AIMS: Our previous study indicated that hepatic bile acids (BAs) may have deposited and stimulated the pathogenesis of a high fat-cholesterol (HFC) diet-induced fibrotic steatohepatitis in stroke-prone spontaneously hypertensive 5/Dmcr rats, based on dysregulated BA homeostasis pathwa
• PMID 24448653

Japanese Journal

• 日本人成人におけるピレスロイド殺虫剤代謝物のバイオモニタリング

• 上山 純,野村 洸司,斎藤 勲,近藤 高明,杉浦 友香,村田 勝敬,岩田 豊人,涌澤 伸哉,上島 通浩
• 日本毒性学会学術年会 40.1(0), 1002019, 2013
• … 合成ピレスロイド系殺虫剤(PYR)は農業用あるいは家庭用殺虫剤として日本人にも馴染のある化学物質であるが，PYR曝露マーカーである尿中クリサンテマムジカルボン酸(CDCA)および３フェノキシ安息香酸(3PBA)排泄量に関する日本人のデータは少ない。 … 本研究では日本人成人の尿中に排泄されるCDCAおよび3PBA量をモニタリングし，それらの季節変動，職域間差および曝露源について検討した。 …
• NAID 130004676499

• Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest

• Uchida Fumihiko,Uzawa Katsuhiro,Kasamatsu Atsushi,Takatori Hiroaki,Sakamoto Yosuke,Ogawara Katsunori,Shiiba Masashi,Tanzawa Hideki,Bukawa Hiroki
• BMC cancer 12, 321, 2012-07
• … BackgroundCell division cycle associated 3 (CDCA3), part of the Skp1-cullin-F-box (SCF) ubiquitin ligase, refers to a trigger of mitotic entry and mediates destruction of the mitosis inhibitory kinase. … Little is known about the relevance of CDCA3 to human malignancy including oral squamous cell carcinoma (OSCC). …
• NAID 120004898305

• 多発性巨大軟部腫瘤を認めた脳腱黄色腫症の1例

• 梅本 勇基,上野 弘貴,原 直之 [他],中村 毅,大槻 俊輔,柳瀬 哲至,山脇 健盛,松本 昌泰
• 日本内科学会雑誌 101(5), 1397-1400, 2012-05-10
• … 脳腱黄色腫症（cerebrotendinous xanthomatosis：CTX）は知能低下，小脳失調，白内障，腱黄色腫を呈する遺伝性代謝疾患である．本例は53歳，女性．四肢に巨大な軟部腫瘤を認め生検により黄色腫と判明．小脳歯状核病変や血清コレスタノール高値からCTXと診断しケノデオキシコール酸（chenodeoxycholic acid：CDCA）とスタチンの投与を開始した．下腿の巨大黄色腫はMRIでT2WI高信号域を認め出血や粘液変性の存在が示唆された． …
• NAID 10031130551

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• CDCA: The Canaan Dog Club of America, Inc.

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Related Pictures

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★リンクテーブル★

リンク元	「ケノデオキシコール酸」
関連記事	「CD」「CDC」

「ケノデオキシコール酸」

　　[★]

英

chenodeoxycholic acid CDCA、chenodeoxycholate

商

ケノコール、コラーザ、レガレン、チノ

関

胆汁酸、胆石溶解剤

「CD」

　　[★]

• 表面抗原分類 cluster of differentiation
• 膠原病 collagen disease
• 集合管 collecting duct
• クローン病 Crohn's disease

　

「CDC」

　　[★] 疾病管理予防センター