同: Carcinoembryonic cell adhesion mole- cule-6

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/15 12:54:30」(JST)

wiki en

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) also known as CD66c (Cluster of Differentiation 66c), is a human gene.^[1]

References

^ "Entrez Gene: CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)".

Oikawa S, Inuzuka C, Kuroki M, et al. (1991). "A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains.". J. Biol. Chem. 266 (13): 7995–8001. PMID 2022629.
Haus O, Noworolska A, Laskowski M, et al. (1990). "Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia.". Exp. Mol. Pathol. 52 (2): 235–42. doi:10.1016/0014-4800(90)90008-2. PMID 2332039.
Hefta SA, Paxton RJ, Shively JE (1990). "Sequence and glycosylation site identity of two distinct glycoforms of nonspecific cross-reacting antigen as demonstrated by sequence analysis and fast atom bombardment mass spectrometry.". J. Biol. Chem. 265 (15): 8618–26. PMID 2341397.
Inazawa J, Abe T, Inoue K, et al. (1990). "Regional assignment of nonspecific cross-reacting antigen (NCA) of the CEA gene family to chromosome 19 at band q13.2.". Cytogenet. Cell Genet. 52 (1–2): 28–31. doi:10.1159/000132833. PMID 2612212.
Neumaier M, Zimmermann W, Shively L, et al. (1988). "Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen". J. Biol. Chem. 263 (7): 3202–7. PMID 2830274.
Kuroki M, Kuroki M, Moore GE, et al. (1988). "The molecular heterogeneity of nonspecific cross-reacting antigen synthesized by tumor cells and granulocytes". Jpn. J. Cancer Res. 79 (1): 82–90. doi:10.1111/j.1349-7006.1988.tb00014.x. PMID 3128509.
Barnett T, Goebel SJ, Nothdurft MA, Elting JJ (1989). "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains". Genomics 3 (1): 59–66. doi:10.1016/0888-7543(88)90160-7. PMID 3220478.
Tawaragi Y, Oikawa S, Matsuoka Y, et al. (1988). "Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence". Biochem. Biophys. Res. Commun. 150 (1): 89–96. doi:10.1016/0006-291X(88)90490-1. PMID 3337731.
Noworolska A, Harłozińska-Szmyrka A, Richter R (1986). "Distribution of surface nonspecific cross-reacting antigen and influence of proteolytic enzymes on this antigen in myeloid cell series". Cancer Detect. Prev. 9 (3–4): 365–71. PMID 3527416.
Oikawa S, Kosaki G, Nakazato H (1987). "Molecular cloning of a gene for a member of carcinoembryonic antigen (CEA) gene family; signal peptide and N-terminal domain sequences of nonspecific crossreacting antigen (NCA)". Biochem. Biophys. Res. Commun. 146 (2): 464–9. doi:10.1016/0006-291X(87)90552-3. PMID 3619891.
Watt SM, Fawcett J, Murdoch SJ, et al. (1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant". Blood 84 (1): 200–10. PMID 8018919.
Honda Y, Egawa K, Kuroki M, Ono T (1997). "Hair cycle-dependent expression of a nonspecific cross reacting antigen (NCA)-50/90-like molecule on follicular keratinocytes". Arch. Dermatol. Res. 289 (8): 457–65. doi:10.1007/s004030050221. PMID 9266023.
Schölzel S, Zimmermann W, Schwarzkopf G, et al. (2000). "Carcinoembryonic Antigen Family Members CEACAM6 and CEACAM7 Are Differentially Expressed in Normal Tissues and Oppositely Deregulated in Hyperplastic Colorectal Polyps and Early Adenomas". Am. J. Pathol. 156 (2): 595–605. doi:10.1016/S0002-9440(10)64764-5. PMC 1850034. PMID 10666389.
Oikawa S, Sugiyama M, Kuroki M, et al. (2001). "Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8". Biochem. Biophys. Res. Commun. 278 (3): 564–8. doi:10.1006/bbrc.2000.3858. PMID 11095950.
Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002). "Deregulated Expression of the Human Tumor Marker CEA and CEA Family Member CEACAM6 Disrupts Tissue Architecture and Blocks Colonocyte Differentiation". Neoplasia 4 (2): 151–63. doi:10.1038/sj/neo/7900201. PMC 1550325. PMID 11896570.
Singer BB, Scheffrahn I, Heymann R, et al. (2002). "Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes". J. Immunol. 168 (10): 5139–46. doi:10.4049/jimmunol.168.10.5139. PMID 11994468.
Skubitz KM, Campbell KD, Skubitz AP (2002). "Synthetic peptides from the N-domains of CEACAMs activate neutrophils". J. Pept. Res. 58 (6): 515–26. doi:10.1034/j.1399-3011.2001.00931.x. PMID 12005421.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Taheri M, Saragovi HU, Stanners CP (2003). "The adhesion and differentiation-inhibitory activities of the immunoglobulin superfamily member, carcinoembryonic antigen, can be independently blocked". J. Biol. Chem. 278 (17): 14632–9. doi:10.1074/jbc.M212500200. PMID 12571231.
Duxbury MS, Ito H, Zinner MJ, et al. (2004). "CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells". Oncogene 23 (2): 465–73. doi:10.1038/sj.onc.1207036. PMID 14724575.

External links

CEACAM6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

English Journal

Significance of CD66c expression in childhood acute lymphoblastic leukemia.

Kiyokawa N1, Iijima K2, Tomita O2, Miharu M3, Hasegawa D4, Kobayashi K2, Okita H2, Kajiwara M5, Shimada H6, Inukai T7, Makimoto A8, Fukushima T9, Nanmoku T10, Koh K11, Manabe A12, Kikuchi A13, Sugita K7, Fujimoto J14, Hayashi Y15, Ohara A16.
Leukemia research.Leuk Res.2014 Jan;38(1):42-8. doi: 10.1016/j.leukres.2013.10.008. Epub 2013 Oct 22.
Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in
PMID 24231528

Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons.

Klaile E1, Klassert TE, Scheffrahn I, Müller MM, Heinrich A, Heyl KA, Dienemann H, Grünewald C, Bals R, Singer BB, Slevogt H.
Respiratory research.Respir Res.2013 Aug 14;14:85. doi: 10.1186/1465-9921-14-85.
BACKGROUND: The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung. They play a role in innate and adaptive immunity and are targets for various bacterial and viral adhesins. Two pathogens tha
PMID 23941132

Adult and pediatric cases of B-cell lymphoblastic leukemia differ in the clinical significance of CD66c expression.

Inaba T1, Nishimura H, Kakae A, Saito J, Yamane Y, Ishizawa M, Imamura T, Fuchida S, Takahashi R, Fujita N.
Laboratory hematology : official publication of the International Society for Laboratory Hematology.Lab Hematol.2013 Jun;19(2):6-7. doi: 10.1532/LH96.12014.
PMID 24014076

Japanese Journal

Differential expression of the carcinoembryonic antigen-related cell adhesion molecules panCD66, CD66a, CD66c and of sialyl-Lewis x (CD15s) on blast cells of acute leukemias

RATEI Richard,KARAWAJEW Leonid,SCHABATH Richard,EHRFELDT Angelika,GRUNERT Fritz,LUDWIG Wolf-Dieter
International journal of hematology 87(2), 137-143, 2008-03-15
NAID 10021255501

CD66b, CD66c and carcinoembryonic antigen (CEA) are independently regulated markers in sera of tumor patients

GRUNERT F.
Int. J. Cancer 63, 349-355, 1995
NAID 80008639234

Related Pictures

blot of granulocytes, ALL samples of CD66c CD13 CD33 CD14 CD11b CD16 CD66b CD66c CD15 CD33 CD117 CD11b CD16 CD66b CD66c CD15 CEACAM-6/CD66c Antibody 0.1 ml CD10+ ALL with My: CD33+; CD66C with Mouse Anti-Human CEACAM‑6/CD66c CEACAM6 / CD66c Antibody (APC), Mouse MAb transfected with (A) human CEACAM-6/CD66c

★リンクテーブル★

「CD66」

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
Identifiers
Symbols	CEACAM6 ; CD66c; CEAL; NCA
External IDs	OMIM: 163980 HomoloGene: 130505 GeneCards: CEACAM6 Gene
Gene ontology
Molecular function	• protein binding;
Cellular component	• plasma membrane; • integral component of plasma membrane; • anchored component of membrane;
Biological process	• signal transduction; • cell-cell signaling;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

同: Carcinoembryonic antigen family

[entrez-1] "Entrez Gene: CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)".

匿名

検索

案内

案内

CD66c

Wikipedia preview

wiki en

Contents

See also