CD66a

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Carcinoembryonic cell adhesion mole- cule-1

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/14 02:16:50」(JST)

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Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
PDB rendering based on 2gk2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2GK2
Identifiers
Symbols	CEACAM1 ; BGP; BGP1; BGPI
External IDs	OMIM: 109770 MGI: 1347245 HomoloGene: 128630 GeneCards: CEACAM1 Gene
Gene ontology Molecular function • molecular_function • protein binding • protein homodimerization activity Cellular component • plasma membrane • integral component of plasma membrane • membrane • integral component of membrane • extracellular vesicular exosome Biological process • angiogenesis • homophilic cell adhesion • integrin-mediated signaling pathway • cell migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	634	26365
Ensembl	ENSG00000079385	ENSMUSG00000074272
UniProt	P13688	P31809
RefSeq (mRNA)	NM_001024912	NM_001039185
RefSeq (protein)	NP_001020083	NP_001034274
Location (UCSC)	Chr 19: 43.01 – 43.07 Mb	Chr 7: 25.46 – 25.48 Mb
PubMed search	[1]	[2]

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a human glycoprotein, encoded by a gene.

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.

In melanocytic cells CEACAM1 gene expression may be regulated by MITF.

Interactions

CEACAM1 has been shown to interact with PTPN11 and Annexin A2.

See also

• Carcinoembryonic antigen
• Cluster of differentiation

References

Further reading

• Gray-Owen SD, Blumberg RS (2006). "CEACAM1: contact-dependent control of immunity.". Nat. Rev. Immunol. 6 (6): 433–46. doi:10.1038/nri1864. PMID 16724098. 
• Svenberg T, Hammarström S, Zeromski J (1979). "Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues". Clin. Exp. Immunol. 36 (3): 436–41. PMC 1537745. PMID 385181. 
• Thompson J, Zimmermann W, Osthus-Bugat P, et al. (1992). "Long-range chromosomal mapping of the carcinoembryonic antigen (CEA) gene family cluster". Genomics 12 (4): 761–72. doi:10.1016/0888-7543(92)90307-E. PMID 1572649. 
• Kuroki M, Arakawa F, Matsuo Y, et al. (1991). "Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library". Biochem. Biophys. Res. Commun. 176 (2): 578–85. doi:10.1016/S0006-291X(05)80223-2. PMID 2025273. 
• Hinoda Y, Neumaier M, Hefta SA, et al. (1988). "Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen". Proc. Natl. Acad. Sci. U.S.A. 85 (18): 6959–63. doi:10.1073/pnas.85.18.6959. PMC 282098. PMID 2457922. 
• Barnett TR, Kretschmer A, Austen DA, et al. (1989). "Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family". J. Cell Biol. 108 (2): 267–76. doi:10.1083/jcb.108.2.267. PMC 2115422. PMID 2537311. 
• Neumaier M, Paululat S, Chan A, et al. (1993). "Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10744–8. doi:10.1073/pnas.90.22.10744. PMC 47854. PMID 7504281. 
• Formisano P, Najjar SM, Gross CN, et al. (1995). "Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase". J. Biol. Chem. 270 (41): 24073–7. doi:10.1074/jbc.270.26.15844. PMID 7592607. 
• Frängsmyr L, Baranov V, Prall F, et al. (1995). "Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa". Cancer Res. 55 (14): 2963–7. PMID 7606710. 
• Najjar SM, Philippe N, Suzuki Y, et al. (1995). "Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase". Biochemistry 34 (29): 9341–9. doi:10.1021/bi00029a009. PMID 7626603. 
• Nédellec P, Turbide C, Beauchemin N (1995). "Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene". Eur. J. Biochem. 231 (1): 104–14. doi:10.1111/j.1432-1033.1995.tb20676.x. PMID 7628460. 
• Watt SM, Fawcett J, Murdoch SJ, et al. (1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant". Blood 84 (1): 200–10. PMID 8018919. 
• Hauck W, Nédellec P, Turbide C, et al. (1994). "Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas". Eur. J. Biochem. 223 (2): 529–41. doi:10.1111/j.1432-1033.1994.tb19022.x. PMID 8055923. 
• Barnett TR, Drake L, Pickle W (1993). "Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins". Mol. Cell. Biol. 13 (2): 1273–82. PMC 359012. PMID 8423792. 
• Kuroki M, Yamanaka T, Matsuo Y, et al. (1996). "Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils". Immunol. Invest. 24 (5): 829–43. doi:10.3109/08820139509060710. PMID 8543346. 
• Huber M, Izzi L, Grondin P, et al. (1999). "The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells". J. Biol. Chem. 274 (1): 335–44. doi:10.1074/jbc.274.1.335. PMID 9867848. 
• Feuk-Lagerstedt E, Jordan ET, Leffler H, et al. (1999). "Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils". J. Immunol. 163 (10): 5592–8. PMID 10553088. 
• Soni P, Lakkis M, Poy MN, et al. (2000). "The Differential Effects of pp120 (Ceacam 1) on the Mitogenic Action of Insulin and Insulin-Like Growth Factor 1 Are Regulated by the Nonconserved Tyrosine 1316 in the Insulin Receptor". Mol. Cell. Biol. 20 (11): 3896–905. doi:10.1128/MCB.20.11.3896-3905.2000. PMC 85733. PMID 10805733. 
• Ergün S, Kilik N, Ziegeler G, et al. (2000). "CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor". Mol. Cell 5 (2): 311–20. doi:10.1016/S1097-2765(00)80426-8. PMID 10882072. 
• Wang L, Lin SH, Wu WG, et al. (2000). "C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers". Clin. Cancer Res. 6 (8): 2988–93. PMID 10955775. 

External links

• CEACAM1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

English Journal

• Expression patterns of CD66a and CD117 in the mouse submandibular gland.

• Takeyama A1, Yoshikawa Y2, Ikeo T2, Morita S3, Hieda Y4.
• Acta histochemica.Acta Histochem.2015 Jan;117(1):76-82. doi: 10.1016/j.acthis.2014.11.004. Epub 2014 Dec 11.
• The epithelial tissue of the salivary gland consists of the acinar and ductal parts, the latter of which is further divided into the intercalated, striated and excretory duct segments and is the residential site for salivary stem/progenitor cells. In the present study, the expression patterns of two
• PMID 25498293

• Abnormal expression of CD66a promotes proliferation and inhibits apoptosis of human leukemic B cells in vitro.

• Zhao W1, Zhang Y, Liu D, Zhong L, He Q, Zhao Y.
• Leukemia & lymphoma.Leuk Lymphoma.2015 Jan;56(1):202-10. doi: 10.3109/10428194.2014.913287. Epub 2014 Jun 6.
• The aberrant expression of myeloid antigen CD66 on acute B-lymphoblastic leukemia (B-ALL) cells is a well-documented phenomenon. CD66a is a major subtype of the CD66 family which plays a dual role in different cancers, and the contradictory effect may depend on the isoform ratio of CD66a-4L to CD66a
• PMID 24716460

• Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons.

• Klaile E1, Klassert TE, Scheffrahn I, Müller MM, Heinrich A, Heyl KA, Dienemann H, Grünewald C, Bals R, Singer BB, Slevogt H.
• Respiratory research.Respir Res.2013 Aug 14;14:85. doi: 10.1186/1465-9921-14-85.
• BACKGROUND: The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung. They play a role in innate and adaptive immunity and are targets for various bacterial and viral adhesins. Two pathogens tha
• PMID 23941132

Japanese Journal

• Differential expression of the carcinoembryonic antigen-related cell adhesion molecules panCD66, CD66a, CD66c and of sialyl-Lewis x (CD15s) on blast cells of acute leukemias

• RATEI Richard,KARAWAJEW Leonid,SCHABATH Richard,EHRFELDT Angelika,GRUNERT Fritz,LUDWIG Wolf-Dieter
• International journal of hematology 87(2), 137-143, 2008-03-15
• NAID 10021255501

• CD66a interactions between human melanoma and NK cells : a novel class I MHC-independent inhibitory mechanism of cytotoxicity

• MARKEL G.
• J Immunol 168(6), 2803-2810, 2002
• NAID 80015206995

• Measurement of circulating biliary glycoprotein (CD66a) in liver diseases

• KONDO Yoshihiro,HINODA Yuji,AKASHI Hirofumi,SAKAMOTO Hirofumi,ITOH Fumio,HIRATA Koichi,KUROKI Masahide,IMAI Kohzoh
• Journal of gastroenterology 36(7), 470-475, 2001-07-01
• NAID 10008552331

Related Links

• CD66a (CEACAM1) - Primary Antibodies: Leica Biosystems

CD66a (CEACAM1) - Antigen Background CD66a antigen, also known as biliary glycoprotein (BGP), is a member of the carcinoembryonic antigen (CEA) family and of...

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