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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/05/20 00:50:35」(JST)

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Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene.^[5]

Function

CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells.^[6]

CCL4 is a major HIV-suppressive factor produced by CD8+ T cells.^[7]

Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.^[8]

CCL4 is produced by: neutrophils, monocytes, B cells, T cells, fibroblasts, endothelial cells, and epithelial cells.^[9]

Concentration of this chemokine has been shown to be inversely related with MicroRNA-125b. Concentration of CCL4 within the body increases with age, which may cause chronic inflammation and liver damage.^[9]^[10]

Interactions

CCL4 has been shown to interact with CCL3.^[11]

CCL4 binds to G protein-Coupled Receptors CCR5 and CCR8.^[9]

References

^ ^a ^b ^c ENSG00000277943, ENSG00000275302 GRCh38: Ensembl release 89: ENSG00000275824, ENSG00000277943, ENSG00000275302 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018930 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Research. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563.
^ Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (December 2001). "B cells and professional APCs recruit regulatory T cells via CCL4". Nature Immunology. 2 (12): 1126–32. doi:10.1038/ni735. PMID 11702067.
^ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science. 270 (5243): 1811–5. doi:10.1126/science.270.5243.1811. PMID 8525373.
^ Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (July 2001). "Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 9283–8. doi:10.1073/pnas.161298998. PMC 55412. PMID 11470920.
^ ^a ^b ^c Morrison MD, Lundquist PG (April 1974). "Labyrinthine morphology and temperature in cryosurgery (guinea pig)". Acta Oto-Laryngologica. 77 (4): 261–73. doi:10.1111/acel.12294. PMC 4364832. PMID 25620312.
^ Morimoto T, Takagi H, Kondo T (January 1985). "Canine pancreatic allotransplantation with duodenum (pancreaticoduodenal transplantation) using cyclosporin A". Nagoya Journal of Medical Science. 47 (1–2): 57–66. doi:10.1074/jbc.M113.526780. PMC 3887178. PMID 24273171.
^ Guan E, Wang J, Norcross MA (April 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

External links

Human CCL4 genome location and CCL4 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

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English Journal

Protective effects of Ziyang tea polysaccharides on CCl4-induced oxidative liver damage in mice.

Wang D, Zhao Y, Sun Y, Yang X.SourceKey Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China.
Food chemistry.Food Chem.2014 Jan 15;143:371-8. doi: 10.1016/j.foodchem.2013.08.005. Epub 2013 Aug 11.
This study was designed to investigate the hepatoprotective effects of the tea polysaccharides (ZTPs) extracted from a selenium-enriched Ziyang green tea (Camellia sinensis). ZTPs were identified as the heteropolysaccharides with glucose (31.4%), arabinose (23.5%) and galactose (21.8%) being the mai
PMID 24054254

Dogs immunized with LBSap vaccine displayed high levels of IL-12 and IL-10 cytokines and CCL4, CCL5 and CXCL8 chemokines in the dermis.

Vitoriano-Souza J, Moreira Nd, Menezes-Souza D, Roatt BM, de Oliveira Aguiar-Soares RD, Siqueira-Mathias FA, de Oliveira Cardoso JM, Giunchetti RC, de Sá RG, Corrêa-Oliveira R, Carneiro CM, Reis AB.SourceLaboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas/NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Molecular immunology.Mol Immunol.2013 Dec 31;56(4):540-8. doi: 10.1016/j.molimm.2013.05.231. Epub 2013 Aug 1.
The complex interplay between cytokines and chemokines regulates innate and adaptive immune responses against pathogens; specifically, cytokine and chemokine expression drives activation of immune effector cells and their recruitment to tissue infection sites. Herein, we inoculated dogs with Leishma
PMID 23911411

Characterisation of polysaccharides from green tea of Huangshan Maofeng with antioxidant and hepatoprotective effects.

Lu X, Zhao Y, Sun Y, Yang S, Yang X.SourceKey Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China.
Food chemistry.Food Chem.2013 Dec 15;141(4):3415-23. doi: 10.1016/j.foodchem.2013.06.058. Epub 2013 Jun 22.
This study was to examine the hepatoprotective effects of polysaccharides from green tea of Huangshan Maofeng (HMTP) against CCl4-induced oxidative damage in mice. HMTP is an acidic heteropolysaccharide with galactose (35.0%, mol.%), arabinose (28.9%) and galacturonic acid (11.3%) being the main mon
PMID 23993501

Japanese Journal

Differences in the Toxicities of Trichothecene Mycotoxins, Deoxynivalenol and Nivalenol, in Cultured Cells

NAGASHIMA Hitoshi,NAKAGAWA Hiroyuki
Japan Agricultural Research Quarterly: JARQ 48(4), 393-397, 2014
… While exposure to DON significantly induced the secretion of anti-hematopoietic cytokines macrophage inflammatory protein-1α (MIP-1α/CCL3) and MIP-1β/CCL4, treatment with NIV decreased the secretion of these cytokines in HL60 cells, indicating that the toxicity mechanisms of these toxins differ. …
NAID 130004701841

Roles of Oxidized Diacylglycerol for Carbon Tetrachloride-induced Liver Injury and Fibrosis in Mouse

Takekoshi Susumu,Kitatani Kanae,Yamamoto Yorihiro
ACTA HISTOCHEMICA ET CYTOCHEMICA, 2014
… In the present study, we explored the roles of oxidized DAG in hepatic fibrogenesis using mice, the livers of which developed fibrosis by long-term administration of carbon tetrachloride (CCl4). … Liver fibrosis models were created by 4- or 8-week repetitive subcutaneous injections of CCl4 to the backs of C57BL/6J mice. … The amount of oxidized DAG was significantly increased in the CCl4-treated group. …
NAID 130004687241

Chloroquine Improved Carbon Tetrachloride-Induced Liver Fibrosis through Its Inhibition of the Activation of Hepatic Stellate Cells: Role of Autophagy

He Wei,Wang Bin,Yang Jing [他],Zhuang Yun,Wang Liangzhi,Huang Xiaodan,Chen Jianping
Biological and Pharmaceutical Bulletin 37(9), 1505-1509, 2014
… Liver fibrosis in rats was induced by carbon tetrachloride (CCl4). … Chloroquine exerts beneficial effects in CCl4-induced liver fibrosis. …
NAID 130004684792

Related Pictures

★リンクテーブル★

リンク元	「MIP-1β」
拡張検索	「chemokine CCL4」「ケモカインCCL4」
関連記事	「CC」「CCL」

「MIP-1β」

CCL4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HUM, 1HUN, 1JE4, 2FFK, 2FIN, 2X6L, 3TN2, 4RAL
Identifiers
Aliases	CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4, C-C motif chemokine ligand 4
External IDs	OMIM: 182284 MGI: 98261 HomoloGene: 48153 GeneCards: CCL4
Gene location (Human)
Chr.	Chromosome 17 (human)
End	36,105,621 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	83,664,683 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• cytokine activity; • CCR5 chemokine receptor binding; • CCR1 chemokine receptor binding; • protein binding; • identical protein binding; • chemokine activity; • CCR chemokine receptor binding;
Cellular component	• extracellular region; • extracellular space;
Biological process	• positive regulation of calcium-mediated signaling; • monocyte chemotaxis; • positive regulation of natural killer cell chemotaxis; • chemokine-mediated signaling pathway; • cellular response to tumor necrosis factor; • cell-cell signaling; • response to virus; • neutrophil chemotaxis; • chemotaxis; • establishment or maintenance of cell polarity; • positive regulation of GTPase activity; • cell adhesion; • cellular response to interleukin-1; • immune response; • positive regulation of ERK1 and ERK2 cascade; • cellular response to interferon-gamma; • response to toxic substance; • signal transduction; • positive regulation of calcium ion transport; • inflammatory response; • regulation of receptor activity; • G-protein coupled receptor signaling pathway; • cytokine-mediated signaling pathway; • eosinophil chemotaxis; • lymphocyte chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6351
	20303
	ENSG00000275824; ENSG00000277943; ENSG00000275302
	ENSMUSG00000018930
	P13236
	P14097
	NM_002984
	NM_013652
	NP_996890; NP_002975
	NP_038680
	Wikidata
View/Edit Human	View/Edit Mouse